{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:38:52Z","timestamp":1774049932991,"version":"3.50.1"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg Rep"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this report is to describe TransOrbital NeuroEndoscopic Surgery (TONES) as a safe alternative for obtaining a cavernous sinus (CS) biopsy. We describe this technique in a patient with a diffuse large B cell lymphoma mimicking Tolosa\u2013Hunt's syndrome. Articles were gathered querying PubMed, Embase, and Scopus databases with terms related to a \u201ctransorbital neuroendoscopic approach.\u201d The literature search was performed by two independent authors (N.L.F. and J.R.), with inconsistencies resolved by the senior author (M.M.D.V.). After screening abstracts for relevance, full-length articles were reviewed for pertinent variables. A comparison was conducted with the illustrative case of a 69-year-old woman who presented to the emergency department with vertigo, ophthalmoplegia, and diplopia for 2 months. A brain magnetic resonance imaging revealed an infiltrative lesion at the left CS. A presumptive diagnosis of Tolosa\u2013Hunt syndrome was made, but a confirmatory biopsy was performed using TONES. Based on our cadaveric study, literature review, and case report, the TONES approach was safe, effective for tissue diagnosis, and associated with minor morbidity and reduced hospital stay. Additional prospective studies are required to study its viability and safety in a larger group of patients.<\/jats:p>","DOI":"10.1055\/a-2155-2419","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T23:05:18Z","timestamp":1692227118000},"page":"e116-e123","source":"Crossref","is-referenced-by-count":2,"title":["TransOrbital NeuroEndoscopic Surgery for Biopsy of the Left Cavernous Sinus: A Literature Review, Case Report, and Cadaveric Proof of Concept"],"prefix":"10.1055","volume":"84","author":[{"given":"Natasha L.","family":"Frontera","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Rosado-Philippi","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Del Valle","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra Santiago","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana V\u00e1zquez","family":"Medina","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo","family":"Figueroa","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Pradilla","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Emory University, Atlanta, Georgia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Garz\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Emory University, Atlanta, Georgia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Emory University, Atlanta, Georgia, United 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