{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:48:37Z","timestamp":1757540917835,"version":"3.37.3"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Peroral endoscopic myotomy (POEM) is a minimally invasive endoscopic procedure for achalasia; its indication has expanded from adults to children. We aimed to evaluate the postoperative efficacy and antireflex status of POEM in young children with achalasia aged 12 years or younger.<\/jats:p><jats:p>\n          Patients\n          and Methods\u2003Pediatric patients with achalasia aged 18 years or younger who underwent POEM in our hospital between 2016 and 2021 were included and divided into two age groups: group A (\u2264 12 years) and group B (13\u201318 years). The success rate (Eckardt score \u2264 3), endoscopic reflux findings, and antiacid use at 1 year postoperatively were compared between the groups.<\/jats:p><jats:p>\n          Results\u2003Ten patients (four boys and six girls; Chicago classification type I: five, type II: four, and unclassified: one) were included. Mean age and preoperative Eckardt scores in groups A (n\u2009=\u20094) and B (n\u2009=\u20096) were 9.2\u2009\u00b1\u20093.0 versus 15.6\u2009\u00b1\u20090.6 years (p\u2009=\u20090.001) and 5.5\u2009\u00b1\u20093.9 versus 7.2\u2009\u00b1\u20093.7 (p\u2009=\u20090.509), respectively, and mean operative time and myotomy length were 51.3\u2009\u00b1\u200916.6 versus 52.5\u2009\u00b1\u200913.2\u2009minutes (p\u2009=\u20090.898) and 10.8\u2009\u00b1\u20094.6 versus 9.8\u2009\u00b1\u20093.2\u2009cm (p\u2009=\u20090.720), respectively. The 1-year success rate was 100% in both groups. Mild esophagitis (Los Angeles classification B) was endoscopically found in one patient in each group (16.7 vs. 25.0%, p\u2009=\u20090.714), and antiacid use was required in three patients (group A, two; group B, one; 50.0 vs. 16.7%, p\u2009=\u20090.500).<\/jats:p><jats:p>\n          Conclusion\u2003The success rate of POEM within 1 year in young children with achalasia aged 12 years or younger was equal to that in adolescent patients. However, young children tended to require antiacids 1 year postoperatively; therefore, long-term follow-up is necessary.<\/jats:p>","DOI":"10.1055\/a-2156-5099","type":"journal-article","created":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T22:58:36Z","timestamp":1692399516000},"page":"097-101","source":"Crossref","is-referenced-by-count":1,"title":["Peroral Endoscopic Myotomy in Pediatric Patients with Achalasia up to 12 Years of Age: A Pilot Study in a Single-Center Experience in Japan"],"prefix":"10.1055","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-3415","authenticated-orcid":false,"given":"Yoshitomo","family":"Samejima","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Okata","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinwa","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan"},{"name":"Department of Internal Medicine, Tanaka Clinic, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzo","family":"Kodama","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Bitoh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1136\/gut.29.1.90","article-title":"Epidemiological study of achalasia in children","volume":"29","author":"J F Mayberry","year":"1988","journal-title":"Gut"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jpeds.2015.10.057","article-title":"Pediatric achalasia in the Netherlands: incidence, clinical course, and quality of life","volume":"169","author":"M Smits","year":"2016","journal-title":"J Pediatr"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4253\/wjge.v6.i4.105","article-title":"Childhood achalasia: a comprehensive review of disease, diagnosis and therapeutic management","volume":"6","author":"A L Franklin","year":"2014","journal-title":"World J Gastrointest Endosc"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-0029-1244080","article-title":"Peroral endoscopic myotomy (POEM) for esophageal achalasia","volume":"42","author":"H Inoue","year":"2010","journal-title":"Endoscopy"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1007\/s00464-014-4040-6","article-title":"Efficacy of peroral endoscopic myotomy (POEM) in the treatment of achalasia: a systematic review and meta-analysis","volume":"29","author":"R Talukdar","year":"2015","journal-title":"Surg Endosc"},{"issue":"07","key":"ref6","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/dote.12387","article-title":"Peroral endoscopic myotomy for the treatment of esophageal achalasia: systematic review and pooled analysis","volume":"29","author":"K Patel","year":"2016","journal-title":"Dis Esophagus"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1053\/j.gastro.2017.10.001","article-title":"Clinical practice update: the use of per-oral endoscopic myotomy in achalasia: expert review and best practice advice from the AGA Institute","volume":"153","author":"P J Kahrilas","year":"2017","journal-title":"Gastroenterology"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1007\/s00464-019-06701-5","article-title":"Peroral endoscopic myotomy (POEM) for the treatment of pediatric achalasia: a systematic review and meta-analysis","volume":"33","author":"Y Lee","year":"2019","journal-title":"Surg Endosc"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00535-019-01607-4","article-title":"Short-term safety and efficacy of peroral endoscopic myotomy for the treatment of achalasia in children","volume":"55","author":"Z Liu","year":"2020","journal-title":"J Gastroenterol"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1055\/s-0039-1697958","article-title":"Surgical management of esophageal achalasia in pediatrics: a systematic review","volume":"30","author":"A Goneidy","year":"2020","journal-title":"Eur J Pediatr Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"E480","DOI":"10.1055\/s-0034-1393156","article-title":"Peroral endoscopic myotomy using the posterior approach in an 11-month-old girl with achalasia, severe malnutrition, and recurrent pneumonia","volume":"47","author":"X C Zhang","year":"2015","journal-title":"Endoscopy"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jpedsurg.2020.02.028","article-title":"Treating children with achalasia using per-oral endoscopic myotomy (POEM): twenty-one cases in review","volume":"55","author":"L S Wood","year":"2020","journal-title":"J Pediatr Surg"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1007\/s00464-018-06654-1","article-title":"Outcome of peroral endoscopic myotomy in children with achalasia","volume":"33","author":"Z Nabi","year":"2019","journal-title":"Surg Endosc"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.thorsurg.2015.12.003","article-title":"Per oral endoscopic myotomy for achalasia: a detailed description of the technique and review of the literature","volume":"26","author":"K L Grimes","year":"2016","journal-title":"Thorac Surg Clin"},{"issue":"06","key":"ref15","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/0016-5085(92)91428-7","article-title":"Predictors of outcome in patients with achalasia treated by pneumatic dilation","volume":"103","author":"V F Eckardt","year":"1992","journal-title":"Gastroenterology"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/SLA.0000000000000992","article-title":"Peroral endoscopic myotomy for esophageal achalasia: outcomes of the first 100 patients with short-term follow-up","volume":"263","author":"P Familiari","year":"2016","journal-title":"Ann Surg"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/gutjnl-2014-308649","article-title":"Clinical response to peroral endoscopic myotomy in patients with idiopathic achalasia at a minimum follow-up of 2 years","volume":"65","author":"Y B Werner","year":"2016","journal-title":"Gut"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/j.gastro.2013.04.057","article-title":"Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study","volume":"145","author":"D Von Renteln","year":"2013","journal-title":"Gastroenterology"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s00464-017-5675-x","article-title":"Per oral endoscopic myotomy vs. laparoscopic Heller myotomy, does gastric extension length matter?","volume":"32","author":"M Ramirez","year":"2018","journal-title":"Surg Endosc"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00464-020-07412-y","article-title":"Risk factors for gastroesophageal reflux after POEM for achalasia: a systematic review and meta-analysis","volume":"35","author":"R CL Mota","year":"2021","journal-title":"Surg Endosc"},{"issue":"42","key":"ref21","doi-asserted-by":"crossref","first-page":"9419","DOI":"10.3748\/wjg.v22.i42.9419","article-title":"Full-thickness myotomy is associated with higher rate of postoperative gastroesophageal reflux disease","volume":"22","author":"X H Wang","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"E190","DOI":"10.1055\/s-0043-121877","article-title":"Outcomes of anterior myotomy versus posterior myotomy during POEM: a randomized pilot study","volume":"6","author":"M Ramchandani","year":"2018","journal-title":"Endosc Int Open"},{"issue":"06","key":"ref23","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1007\/s00464-021-08763-w","article-title":"Safety and effectiveness of sling fiber preservation POEM to reduce severe post-procedural erosive esophagitis","volume":"36","author":"H Shiwaku","year":"2022","journal-title":"Surg Endosc"},{"issue":"05","key":"ref24","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jpedsurg.2015.02.047","article-title":"Treatment of esophageal achalasia in children: Today and tomorrow","volume":"50","author":"T Caldaro","year":"2015","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.gie.2014.06.035","article-title":"Long-term outcomes of peroral endoscopic myotomy for achalasia in pediatric patients: a prospective, single-center study","volume":"81","author":"W F Chen","year":"2015","journal-title":"Gastrointest Endosc"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.gie.2017.09.029","article-title":"Adverse events during and after per-oral endoscopic myotomy: prevention, diagnosis, and management","volume":"87","author":"Z Nabi","year":"2018","journal-title":"Gastrointest Endosc"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"doaa112","DOI":"10.1093\/dote\/doaa112","article-title":"Clinical outcomes of peroral endoscopic myotomy for achalasia in children: a systematic review and meta-analysis","volume":"34","author":"C Zhong","year":"2021","journal-title":"Dis Esophagus"},{"issue":"08","key":"ref28","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/ajg.2017.139","article-title":"Comprehensive analysis of adverse events associated with per oral endoscopic myotomy in 1826 patients: an international multicenter study","volume":"112","author":"Y Haito-Chavez","year":"2017","journal-title":"Am J Gastroenterol"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1007\/s00464-012-2336-y","article-title":"Perioperative management and treatment for complications during and after peroral endoscopic myotomy (POEM) for esophageal achalasia (EA) (data from 119 cases)","volume":"26","author":"Z Ren","year":"2012","journal-title":"Surg Endosc"},{"issue":"03","key":"ref30","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jamcollsurg.2013.04.033","article-title":"Peroral endoscopic myotomy for the treatment of achalasia: a clinical comparative study of endoscopic full-thickness and circular muscle myotomy","volume":"217","author":"Q L Li","year":"2013","journal-title":"J Am Coll Surg"}],"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2156-5099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:35:46Z","timestamp":1730810146000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2156-5099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,18]]},"references-count":30,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,2,22]]},"published-print":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2156-5099","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"type":"print","value":"0939-7248"},{"type":"electronic","value":"1439-359X"}],"subject":[],"published-other":{"date-parts":[[2023,8,18]]},"published":{"date-parts":[[2023,8,18]]}}}