{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:15:08Z","timestamp":1791922508485,"version":"4.3.4"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aims Offspring exposed to an adverse fetal environment, such as\n                    gestational diabetes, may manifest increased susceptibility to several chronic\n                    diseases later in life. In the present study, the cardiovascular function of\n                    three different ages of offspring from diabetic rats was evaluated.<\/jats:p><jats:p>\n          Methods and results Diabetes mellitus was induced in pregnant rats by a\n                    single dose of streptozotocin (50\u2009mg\/kg). The offspring from\n                    diabetic (OD) and control rats (OC) were evaluated at three different ages: 6,\n                    12 or 18 months. In the corresponding OC groups, fasting glycemia, baseline mean\n                    arterial pressure, and sympathetic tonus increased in the OD rats at 12 (OD12)\n                    and 18 (OD18) months of age, while cardiac hypertrophy was observed in all OD\n                    groups. Cardiac function evaluation in vivo showed low left ventricular\n                    systolic pressure and+dP\/dt in the OD18 rats, suggesting a\n                    systolic dysfunction. OD12 and OD18 groups showed high left ventricle\n                    end-diastolic pressure, suggesting a diastolic dysfunction. OD groups showed an\n                    age-related impairment of both baroreflex-mediated tachycardia and\n                    baroreflex-mediated bradycardia in OD12 and OD18 rats. In isolated hearts from\n                    OD18 rats, both inotropic and tachycardiac responses to increasing isoproterenol\n                    were significantly reduced compared to the corresponding OC group.<\/jats:p><jats:p>\n          Conclusion These results suggest that gestational diabetes triggers the\n                    onset of hyperglycemia hypertension with impaired baroreflex sensitivity and\n                    heart failure in older age of offspring, representing important risk factors for\n                    death. Therefore, ensuring optimal glycemic control in diabetic pregnancy is\n                    important and serves as a key to preventing cardiovascular disease in the\n                    offspring in their older age.<\/jats:p>","DOI":"10.1055\/a-2159-6468","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T23:09:52Z","timestamp":1695856192000},"page":"615-623","source":"Crossref","is-referenced-by-count":4,"title":["Maternal Hyperglycemia Induces Autonomic Dysfunction and Heart\n                    Failure in Older Adult Offspring"],"prefix":"10.1055","volume":"131","author":[{"given":"Odair Alves","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of\n                    Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00f3ria Pinto","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of\n                    Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Lahlou","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, School of Medicine, Federal\n                    University of Cear\u00e1, Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","article-title":"Hyperglycemia and adverse pregnancy outcomes","volume":"358","author":"B E Metzger","year":"2008","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.siny.2009.01.002","article-title":"Offspring of diabetic pregnancy: Long-term outcomes","volume":"14","author":"U Simeoni","year":"2009","journal-title":"Semin Fetal Neonatal Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/bmj.298.6673.564","article-title":"Growth in utero, blood pressure in childhood and adult life, and mortality from\n                    cardiovascular disease","volume":"298","author":"D J Barker","year":"1989","journal-title":"BMJ"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.2337\/dc10-S011","article-title":"standards of medical care in diabetes","volume":"33","author":"American Diabetes Association","year":"2010","journal-title":"Diabetes Care"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.2337\/dc14-S014","article-title":"Clinical practice recommendations, standards of medical care in diabetes","volume":"37","author":"American Diabetes Association","year":"2014","journal-title":"Diabetes Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.180605","article-title":"Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus","volume":"193","author":"A A Like","year":"1976","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/bdra.10137","article-title":"Immunostimulation by complete Freund\u2019s adjuvant, granulocyte macrophage\n                    colony-stimulating factor, or interferon-gamma reduces severity of diabetic\n                    embryopathy in ICR mice","volume":"70","author":"K Punareewattana","year":"2004","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/dmr.5610110106","article-title":"The pathogenesis of congenital malformations in diabetic pregnancy","volume":"11","author":"U J Ericksson","year":"1995","journal-title":"Diabetes Metab Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/bdra.20357","article-title":"Aortic and ventricular dilation and myocardial reduction in gestation day 17 ICR\n                    mouse fetuses of diabetic mothers","volume":"79","author":"J C Gutierrez","year":"2007","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1055\/s-0029-1241824","article-title":"Effects of K+channels inhibitors on the cholinergic\n                    relaxation of the isolated aorta of adult offspring rats exposed to maternal\n                    diabetes","volume":"118","author":"NP C Porto","year":"2010","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e50593","DOI":"10.1371\/journal.pone.0050593","article-title":"Increased cyclooxygenase-2-derived prostanoids contributes to the\n                    hyperreactivity to noradrenaline in mesenteric resistance arteries from\n                    offspring of diabetic rats","volume":"7","author":"F E Ramos-Alves","year":"2012","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s001250051117","article-title":"Streptozotocin diabetes in the pregnant rat induces cardiovascular dysfunction\n                    in adult offspring","volume":"42","author":"K Holemans","year":"1999","journal-title":"Diabetologia"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000324863","article-title":"Programming of adult cardiovascular disease following exposure to late-gestation\n                    hyperglycemia","volume":"100","author":"M Agoudemos","year":"2011","journal-title":"Neonatology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00582527","article-title":"Effects of pyruvate on post-ischaemic myocardial recovery at various\n                    workloads","volume":"413","author":"M Van Bilsen","year":"1988","journal-title":"Pfl\u00fcgers Arch"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1054\/jpai.2001.21592","article-title":"Rapid onset of pain induced by intravenous streptozotocin in the rat","volume":"2","author":"O A Kochuvelikakam","year":"2001","journal-title":"J Pain"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.5534\/wjmh.180057","article-title":"Comparison of Improving Effects for Diabetic Erectile dysfunction according to\n                    the anti-glycemic agents: Phlorizin and insulin","volume":"37","author":"J Park","year":"2019","journal-title":"World J Mens Health"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S1995-7645(12)60023-6","article-title":"Antihyperglycemic effects of the methanol leaf extract of Diaphananthe bidens in\n                    normoglycemic and streptozotocin-induced hyperglycemic rats","volume":"5","author":"A A Ottah","year":"2012","journal-title":"Asian Pac J Trop Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.physbeh.2012.08.001","article-title":"Impact of maternal mild hyperglycemia on maternal care and offspring development\n                    and behavior of Wistar rats","volume":"107","author":"AC I Kiss","year":"2012","journal-title":"Physiol Behav"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1111\/j.1476-5381.2012.01945.x","article-title":"Effect of age and COX-2-derived prostanoids on the progression of adult vascular\n                    dysfunction in the offspring of diabetic rats","volume":"166","author":"F E Ramos-Alves","year":"2012","journal-title":"Br J Pharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1034\/j.1600-0773.2003.920409.x","article-title":"Blunted central bromocriptine-induced tachycardia in conscious, malnourished\n                    rats","volume":"92","author":"S Lahlou","year":"2003","journal-title":"Pharmacol Toxicol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1139\/y99-136","article-title":"Effects of long-term pretreatment with isoproterenol on bromocriptine-induced\n                    tachycardia in conscious rats","volume":"78","author":"S Lahlou","year":"2000","journal-title":"Can J Pharmacol Physiol"},{"key":"ref22","first-page":"624","article-title":"The laboratory rat: Relating its age with human\u2019s","volume":"4","author":"P Sengupta","year":"2013","journal-title":"Int J Prev Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1210\/jc.2006-2175","article-title":"Epidemiological evidence of altered cardiac autonomic function in subjects with\n                    impaired glucose tolerance but not isolated impaired fasting glucose","volume":"92","author":"J S Wu","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.33549\/physiolres.932304","article-title":"Modulation of baroreflex function by rosiglitazone in prediabetic hyperglycemic\n                    rats","volume":"61","author":"L Z Hong","year":"2012","journal-title":"Physiol Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s001250051117","article-title":"Streptozotocin diabetes in the pregnant rat induces cardiovascular dysfunction\n                    in adult offspring","volume":"42","author":"K Holemans","year":"1999","journal-title":"Diabetologia"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/01.HYP.21.2.136","article-title":"The vasodilator action of insulin: implication for the insulin hypothesis of\n                    hypertension","volume":"21","author":"E A Anderson","year":"1993","journal-title":"Hypertension"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/01.HYP.19.1_Suppl.I61","article-title":"Hyperinsulinemia: Possible role in obesity-induced hypertension","volume":"19","author":"L Landsberg","year":"1992","journal-title":"Hypertension"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1203\/01.pdr.0000188698.58021.ff","article-title":"Long-term effects of maternal diabetes on vascular reactivity and renal function\n                    in rat male offspring","volume":"58","author":"S O Rocha","year":"2005","journal-title":"Pediatr Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0002-9440(10)63626-7","article-title":"Analysis of the Zucker Diabetic Fatty (ZDF) type 2 diabetic rat model suggests a\n                    neurotrophic role for insulin\/IGF-I in diabetic autonomic\n                    neuropathy","volume":"163","author":"R E Schmidt","year":"2003","journal-title":"A J Pathol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/B978-0-444-53491-0.00022-5","article-title":"Diabetic autonomic neuropathy","volume":"117","author":"A I Vinik","year":"2013","journal-title":"Handb Clin Neurol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0735-1097(98)00128-4","article-title":"Scintigraphic assessment of regionalized defects in myocardial sympathetic\n                    innervation and blood flow regulation in diabetic patients with autonomic\n                    neuropathy","volume":"31","author":"M J Stevens","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1515\/JPM.2005.042","article-title":"Echocardiographic measurements in infants of diabetic mothers and macrosomic\n                    infants of nondiabetic mothers","volume":"33","author":"K Demiroren","year":"2005","journal-title":"J Perinat Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMoa032566","article-title":"Diastolic heart failure: Abnormalities in active relaxation and passive\n                    stiffness of the left ventricle","volume":"350","author":"M R Zile","year":"2004","journal-title":"N Engl J Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1113\/jphysiol.2010.202838","article-title":"Mitochondrial production of reactive oxygen species contributes to the\n                    \u03b2-adrenergic stimulation of mouse cardiomycytes","volume":"589","author":"D C Andersson","year":"2011","journal-title":"J Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"61A","DOI":"10.1016\/0735-1097(93)90465-D","article-title":"Changes in myocardial and vascular receptors in heart failure","volume":"22","author":"M R Bristow","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3389\/fphys.2013.00324","article-title":"Adrenergic signaling and oxidative stress: A role for sirtuins?","volume":"4","author":"G Corbi","year":"2013","journal-title":"Front Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1007\/s00125-007-0823-9","article-title":"Impaired short-term blood pressure regulation and autonomic dysbalance in\n                    children with type 1 diabetes mellitus","volume":"50","author":"R Dalla-Pozza","year":"2007","journal-title":"Diabetologia"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/S0735-1097(01)01110-X","article-title":"Predictive value of systolic and diastolic function for incident congestive\n                    heart failure in the elderly: The Cardiovascular Health Study","volume":"37","author":"G P Aurigemma","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/S0735-1097(99)00118-7","article-title":"Congestive heart failure in subjects with normal versus reduced left ventricular\n                    ejection fraction: Prevalence and mortality in a population-based cohort","volume":"33","author":"R Vasan","year":"1999","journal-title":"J Am Coll Cardiol"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2159-6468.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T23:41:57Z","timestamp":1700005317000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2159-6468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,27]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11,14]]},"published-print":{"date-parts":[[2023,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2159-6468","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,27]]}}}