{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T06:48:52Z","timestamp":1785653332513,"version":"3.56.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>For the first time since 1971, new regulations were introduced for cervical cancer\n        screening as an organized cancer screening guideline (oKFE-RL) starting 1 January 2020. From\n        the age of 20, a cytological smear test is performed annually, and from the age of 35,\n        so-called co-testing (cytology and test for high-risk HPVs) is performed every three years.\n        In case of abnormalities, the algorithm is used as the basis for investigation. According to\n        this diagnostic algorithm, even so-called low-risk groups receive early colposcopic\n        evaluation. This approach has been heavily debated and serves as the basis for this registry\n        study.<\/jats:p>\n                  <jats:p>All patients who presented to the centers for a colposcopy as part of the diagnostic\n        algorithm were included after signing an informed consent form. The following findings were\n        obtained: Medical history, colposcopy, histology, and cytology findings, as well as possible\n        therapies and their findings. The aim was to evaluate the frequency of the target lesions\n        cervical intraepithelial neoplasia (CIN) 2+\/CIN\u00a03+ in the respective groups.<\/jats:p>\n                  <jats:p>A total of 4763 patients were enrolled in the study from July 2020 to October 2022. As a\n        referral diagnosis, HPV persistence (HPV: human papillomavirus) with group I was determined\n        in 23.9% (1139), HPV persistence with group II-a in 2.1% (100), II-p (ASC-US) in 11.2%\n        (535), and II-g (AGC endocervical NOS) in 1.3% (64). III-p (ASC-H) and III-g (AGC\n        endocervical favor neoplastic) were found in 9.4% (447) and 2.2% (107), respectively, IIID1\n        (LSIL) in 19% (906), IIID2 (HSIL, moderate dysplasia) in 18.9% (898), IVa-p (HSIL, severe\n        dysplasia) in 10.7% (508), IVa-g (AIS) in 0.7% (31), IVb-p (HSIL with features suspicious\n        for invasion) and IVb-g (AIS with features suspicious for invasion) in 0.3% (15), 0.1% (6),\n        and 7 with suspected invasion V-p (squamous cell carcinoma)\/V-g (endocervical\n        adenocarcinoma) (0.1%). In the IVa-p group (HSIL, severe dysplasia), 67.7% had CIN\u00a02+ and\n        56.5% had CIN\u00a03+, adenocarcinoma in situ (AIS), and adenocarcinoma. If the histology of the\n        excised tissue specifically based on the colposcope findings was also evaluated, CIN\u00a02+ was\n        found in 79.7% of cases, and CIN\u00a03+ in 67.3% of cases. In IIID2 (HSIL, moderate dysplasia),\n        CIN\u00a02+ was detected in 50.9%, and CIN\u00a03+\/AIS in 28.3%. After evaluating patients who\n        underwent surgery immediately, this increased to 53.0% for CIN\u00a02+ and 29.3% for CIN\u00a03+\/AIS.\n        In IIID1 (LSIL), CIN\u00a02+ was detected in 27.4% and CIN\u00a03+\/AIS in 11.7%, and in II-p (ASC-US),\n        CIN\u00a02+ was detected in 23.4% and CIN\u00a03+ and AIS in 10.8%, and in II-g (AGC endocervical\n        NOS), CIN\u00a02+ was detected in 34.4% and CIN\u00a03+ in 23.4%. In the HPV persistence\/II-a and I\n        group, 21% showed CIN\u00a02+, and 12.1% showed CIN\u00a03+ and AIS, and 13% showed CIN\u00a02+ and 5.9%\n        showed CIN\u00a03+ and AIS. In patients who were HPV-negative and had further diagnostics\n        performed on the basis of cytologic smear alone, 27.9% had CIN\u00a02+, and 14.1% had CIN\u00a03 and\n        AIS.<\/jats:p>\n                  <jats:p>In a synopsis of the present findings of our initial data of the registry study on the\n        new cervical cancer screening, according to the organized early cancer screening guideline\n        (oKFE-RL), we could show that the target lesion CIN\u00a03+ and AIS is detected unexpectedly\n        frequently in a not insignificant proportion, especially in the cytological low-risk group.\n        Currently, we cannot answer whether this can reduce the incidence and mortality of cervical\n        carcinoma, but this could be an initial indication of this and will be reviewed in further\n        long-term evaluations.<\/jats:p>","DOI":"10.1055\/a-2159-7510","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T04:01:36Z","timestamp":1696564896000},"page":"1250-1262","source":"Crossref","is-referenced-by-count":9,"title":["Registry Study of the Working Group on Cervical Pathology and Colposcopy (AGCPC) on the Diagnostic Algorithm for the New Cervical Cancer Screening \u2013 Initial Data"],"prefix":"10.1055","volume":"83","clinical-trial-number":[{"clinical-trial-number":"drks00024931","registry":"10.18810\/drks"}],"author":[{"given":"Melanie","family":"Henes","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Frauengesundheit T\u00fcbingen, Universit\u00e4tsfrauenklinik, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Mann","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsfrauenklinik und Poliklinik am Klinikum S\u00fcdstadt Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Hirchenhain","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Bauer","sequence":"additional","affiliation":[{"name":"amedes MVZ f\u00fcr Gyn\u00e4kologie und Pathologie M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kentner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Frauenheilkunde und Geburtshilfe, Erfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Quaas","sequence":"additional","affiliation":[{"name":"Facharztpraxis f\u00fcr Frauenheilkunde und Geburtshilfe, Hansestadt Stralsund, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ko\u00dfagk","sequence":"additional","affiliation":[{"name":"Gyn\u00e4kologisches Versorgungszentrum Kreuzberg MVZ\/K\u00f6penick, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Gallwas","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Universit\u00e4tsmedizin G\u00f6ttingen, Georg-August-Universit\u00e4t, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Henes","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Frauengesundheit T\u00fcbingen, Universit\u00e4tsfrauenklinik, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Frauengesundheit T\u00fcbingen, Universit\u00e4tsfrauenklinik, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8692-8202","authenticated-orcid":false,"given":"Volkmar","family":"K\u00fcppers","sequence":"additional","affiliation":[{"name":"Zytologisches Labor, Facharztpraxis f\u00fcr Frauenheilkunde und Geburtshilfe, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"issue":"S 1","key":"ref1","first-page":"6","article-title":"Beschluss des Gemeinsamen Bundesausschusses \u00fcber eine \u00c4nderung der\n          Krebs-fr\u00fcherkennungs-Richtlinie und eine \u00c4nderung der Richtlinie f\u00fcr organisierte\n          Krebsfr\u00fcherkennungsprogramme: Programm zur Fr\u00fcherkennung von Zervixkarzinomen","volume":"22","author":"Gemeinsamer Bundesausschuss","year":"2019","journal-title":"gyn"},{"issue":"S 1","key":"ref2","first-page":"25","article-title":"Tragende 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Bundesweite Jahresstatistik nach der\n          Nomenklaturreform","volume":"58","author":"K Marquardt","year":"2017","journal-title":"Frauenarzt"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00292-017-0382-x","article-title":"M\u00fcnchner Nomenklatur III: Klassifikation nach Risikoverlaufsbeobachtung bei\n          auff\u00e4lligen plattenepithelialen Befunden","volume":"39","author":"K Marquardt","year":"2018","journal-title":"Pathologe"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/LGT.0b013e3182854253","article-title":"Five-year risks of CIN 3+ and cervical cancer among women with HPV testing of\n          ASC-US Pap results","volume":"17","author":"HA Katki","year":"2013","journal-title":"J Lower Gen Tract Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/LGT.0b013e3182854269","article-title":"Five-Year Risks of CIN 2+ and CIN 3+ among women with HPV-positive and\n          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