{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:23Z","timestamp":1787004863829,"version":"build-2736575974"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The presentation of the results of the prospective randomized international multicenter study AGO-OP.8 \u2013 CCTG CX.5 \u2013 SHAPE at the annual conference of the American Society of Clinical\n          Oncology (ASCO) in 2023 will affect the surgical treatment of early-stage cervical cancer. In the SHAPE study, simple total hysterectomy (experimental arm) was found to be non-inferior to\n          radical hysterectomy (standard arm) to treat patients with early-stage cervical cancer (FIGO stages [2018] IA2 \u2013 IB1 \u2264\u20092\u2009cm with an infiltration depth of &lt;\u20091\u2009cm); after 3\u00a0years\u02bc follow-up\n          the pelvic recurrence rate was 2.52% (experimental arm) compared to 2.17% (standard arm) with no statistically significant difference with regards to recurrence-free survival and overall\n          survival rates. After weighing up the results of the SHAPE study published at the conference, the Uterus Organ Commission of AGO is of the opinion that, in addition to the use of radical\n          hysterectomy to treat patients with invasive cervical cancer which is FIGO stage IA2 \u2013 IB1 \u2264\u20092\u2009cm with an infiltration depth of &lt;\u20091\u2009cm, simple total hysterectomy may also be considered\n          for primary surgical therapy on a case-by-case basis after suitable explanation of the associated risks. It will be necessary to wait for the data of the full publication before discussing\n          whether this approach should be included in official guidelines and defining it as a new therapy standard.<\/jats:p>","DOI":"10.1055\/a-2160-3279","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T04:01:36Z","timestamp":1696564896000},"page":"1199-1204","source":"Crossref","is-referenced-by-count":7,"title":["Statement of the Uterus Commission of the Gynecological Oncology Working Group (AGO) on Surgical Therapy for Patients with Stage IA2\u2013IIB1 Cervical\n          Cancer"],"prefix":"10.1055","volume":"83","author":[{"given":"Tanja","family":"Fehm","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsfrauenklinik der Universit\u00e4t D\u00fcsseldorf, CIO ABCD, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias W.","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Frauenklinik, Comprehensive Cancer Center ER-EMN, Universit\u00e4tsklinikum Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Mahner","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, LMU-Klinikum M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Denschlag","sequence":"additional","affiliation":[{"name":"Frauenklinik, Hochtaunus Kliniken, Bad Homburg, Bad Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Brucker","sequence":"additional","affiliation":[{"name":"Universit\u00e4ts-Frauenklinik T\u00fcbingen, Department f\u00fcr Frauengesundheit, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hillemanns","sequence":"additional","affiliation":[{"name":"Frauenklinik, Comprehensive Cancer Center Niedersachsen, Medizinische Hochschule Hannover, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Tempfer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsfrauenklinik, Comprehensive Cancer Center der Ruhr Universit\u00e4t Bochum (RUCCC), Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Uterus Commission of the AGO and the AGO Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"LBA5511","DOI":"10.1200\/JCO.2023.41.17_suppl.LBA5511","article-title":"An international randomized phase III trial comparing radical hysterectomy and pelvic node dissection (RH) vs. simple hysterectomy and pelvic node dissection (SH) in patients with low-risk\n          early-stage cervical cancer (LRESCC): A Gynecologic Cancer Intergroup study led by the Canadian Cancer Trials Group (CCTG CX.5-SHAPE)","volume":"41","author":"M Plante","year":"2023","journal-title":"J Clin Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1200\/JCO.19.03012","article-title":"Recurrence Rates in Patients With Cervical Cancer Treated With Abdominal Versus Minimally Invasive Radical Hysterectomy: A Multi-Institutional Retrospective Review Study","volume":"38","author":"S Uppal","year":"2020","journal-title":"J Clin Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/ijgc-2021-002544","article-title":"SUCCOR cone study: conization before radical hysterectomy","volume":"32","author":"E Chacon","year":"2022","journal-title":"Int J Gynecol Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00404-021-06145-0","article-title":"Association of preoperative cone biopsy with recurrences after radical hysterectomy","volume":"305","author":"R Klapdor","year":"2022","journal-title":"Arch Gynecol Obstet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ygyno.2020.06.508","article-title":"Predictors of recurrence following laparoscopic radical hysterectomy for early-stage cervical cancer: A multi-institutional study","volume":"159","author":"J Casarin","year":"2020","journal-title":"Gynecol Oncol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ygyno.2021.12.023","article-title":"Cervical conization before primary radical hysterectomy has a protective effect on disease recurrence in early cervical cancer: A two-center matched cohort study according to surgical\n          approach","volume":"164","author":"S I Kim","year":"2022","journal-title":"Gynecol Oncol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ygyno.2010.12.352","article-title":"Conservative management of early stage cervical cancer: is there a role for less radical surgery?","volume":"120","author":"K M Schmeler","year":"2011","journal-title":"Gynecol Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1136\/ijgc-2021-002921","article-title":"ConCerv: a prospective trial of conservative surgery for low-risk early-stage cervical cancer","volume":"31","author":"K M Schmeler","year":"2021","journal-title":"Int J Gynecol Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ajog.2020.11.041","article-title":"Less radical surgery for early-stage cervical cancer: a systematic review","volume":"224","author":"J Wu","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ygyno.2017.02.005","article-title":"Sensitivity and negative predictive value for sentinel lymph node biopsy in women with early-stage cervical cancer","volume":"145","author":"G Salvo","year":"2017","journal-title":"Gynecol Oncol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1056\/NEJMoa1806395","article-title":"Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer","volume":"379","author":"P T Ramirez","year":"2018","journal-title":"N Engl J Med"}],"container-title":["Geburtshilfe und 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