{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:46:36Z","timestamp":1753274796526,"version":"3.37.3"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>McKittrick\u2013Wheelock syndrome (MKWS) is an uncommon clinical manifestation of large, villous, epithelial lesions of the distal colon and rectum. Excessive secretion of electrolyte-rich mucus from these lesions leads to secretory diarrhea, electrolyte disorders and acute renal failure. Several cases of MKWS have been reported since its initial description in 1954. The definitive treatment for the great majority of MKWS cases has consisted of surgical resection of the affected part of the colorectum, usually in the form of a low anterior resection or an abdominoperineal resection with the formation of an ostomy. Recent developments in endoscopic resection techniques now offer new, minimally invasive treatment alternatives for MKWS patients. We present the first reported case in the Western world of MKWS caused by a rectal adenoma with a size of 19 \u00d7 10 cm, treated through endoscopic submucosal dissection. Through the lessons learned by this case, as well as by a thorough review of the literature, we discuss this uncommon syndrome, focusing on treatment alternatives.<\/jats:p>","DOI":"10.1055\/a-2163-5913","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T22:55:18Z","timestamp":1695768918000},"page":"944-951","source":"Crossref","is-referenced-by-count":2,"title":["Endoscopic Submucosal Dissection of a Giant Rectal Adenoma Manifesting as McKittrick-Wheelock Syndrome"],"prefix":"10.1055","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8294-6673","authenticated-orcid":false,"given":"Konstantinos","family":"Kouladouros","sequence":"additional","affiliation":[{"name":"Central Interdisciplinary Endoscopy Department, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Schneider","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1, Klinikum am Steinenberg, Reutlingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Kubicka","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1, Klinikum am Steinenberg, Reutlingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hoerner","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hirth","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Medical Centre Mannheim, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/J.CCA.2014.05.001","article-title":"McKittrick-Wheelock syndrome may represent the extreme of a normally distributed continuum of secretory activity in colorectal villous adenomas","volume":"436","author":"P Nicholson","year":"2014","journal-title":"Clin Chim Acta"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1308\/RCSANN.2018.0184","article-title":"A systematic review of McKittrick-Wheelock syndrome","volume":"100","author":"MR Orchard","year":"2018","journal-title":"Ann R Coll Surg Engl"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1007\/BF02070718","article-title":"Carcinoma of the colon. 1954","volume":"40","author":"LS McKittrick","year":"1997","journal-title":"Dis Colon Rectum"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1089\/LAP.2017.0195","article-title":"McKittrick Wheelock syndrome treated by transanal minimally invasive surgery: a single-center experience and review of the literature","volume":"28","author":"AEM Van Der Pool","year":"2018","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"ref5","first-page":"A5567","article-title":"McKittrick-Wheelock syndrome","volume":"157","author":"R Barendse","year":"2013","journal-title":"Ned Tijdschr Geneeskd"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1007\/S12328-015-0597-4","article-title":"Electrolyte depletion syndrome (McKittrick-Wheelock syndrome) successfully treated by endoscopic submucosal dissection","volume":"8","author":"Y Ohara","year":"2015","journal-title":"Clin J Gastroenterol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/J.AJEM.2009.09.001","article-title":"McKittrick-Wheelock syndrome: is it really rare?","volume":"28","author":"C Caliskan","year":"2010","journal-title":"Am J Emerg Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/S0140-6736(59)91830-6","article-title":"Potassium-secreting tumours of the large intestine","volume":"1","author":"AD Roy","year":"1959","journal-title":"Lancet"},{"key":"ref9","first-page":"121","article-title":"Hypersecreting villous rectosigmoid tumors. 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