{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T05:10:59Z","timestamp":1738905059343,"version":"3.37.0"},"reference-count":26,"publisher":"American Academy of Audiology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j am acad audiol"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:p><jats:bold>Abstract<\/jats:bold>  <jats:bold>Background:<\/jats:bold>\u2003Congenital hypothyroidism (CH) is one of the most preventable causes of intellectual disability in the world. Screening programs have led to earlier detection of CH, and children with adequate thyroid supplementation can have minor long-term\n differences in overall neuropsychological testing compared to baseline. <jats:bold>Purpose:<\/jats:bold>\u2003Despite early identification, up to one-fourth of children born with CH suffer from hearing loss even with early and adequate thyroid hormone supplementation. We present a unique case of an individual\n born with congenital hypothyroidism found to have sensorineural hearing loss. <jats:bold>Research Design:<\/jats:bold>\u2003Case report. <jats:bold>Study Sample:<\/jats:bold>\u2003Single subject. <jats:bold>Intervention:<\/jats:bold>\u2003Diagnosis of congenital hypothyroidism at 1 week of life and initiation of treatment with\n levothyroxine. <jats:bold>Data Collection and Analysis:<\/jats:bold>\u2003Degree of hearing loss was measured with age-appropriate audiological testing at ages 4 weeks, 7 weeks, 3 months, 7 months, 9 months, 11 months, and 12 months. <jats:bold>Results:<\/jats:bold>\u2003The patient was treated early with thyroid hormone\n supplementation and demonstrated full recovery of hearing by age 12 months. <jats:bold>Conclusions:<\/jats:bold>\u2003Despite the body of literature documenting hearing loss as an ongoing complication of CH, this patient demonstrates a unique case of full hearing recovery with early treatment.<\/jats:p>","DOI":"10.1055\/a-2165-0789","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T23:10:50Z","timestamp":1693609850000},"page":"225-229","source":"Crossref","is-referenced-by-count":0,"title":["Full Recovery of Sensorineural Hearing Loss in a Patient with Congenital Hypothyroidism"],"prefix":"10.3766","volume":"34","author":[{"given":"Jacline G.","family":"Phillips","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha B.","family":"Fabian","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin W.","family":"Adkins","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor P.","family":"Kiell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2087","reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s40272-017-0238-0","article-title":"Pediatric hypothyroidism: diagnosis and treatment","volume":"19","author":"A J Wassner","year":"2017","journal-title":"Paediatr Drugs"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1210\/jc.2011-1175","article-title":"Approach to the diagnosis and treatment of neonatal hypothyroidism","volume":"96","author":"S H LaFranchi","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1542\/peds.2007-1422","article-title":"Universal newborn hearing screening: systematic review to update the 2001 US Preventive Services Task Force Recommendation","volume":"122","author":"H D Nelson","year":"2008","journal-title":"Pediatrics"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1515\/JPEM.2007.20.5.559","article-title":"How should we be treating children with congenital hypothyroidism?","volume":"20","author":"S H LaFranchi","year":"2007","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1210\/en.2011-1722","article-title":"Hear, hear! Thyroid hormone transporters in cochlear development","volume":"152","author":"H Heuer","year":"2011","journal-title":"Endocrinology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3109\/00016487609119981","article-title":"The role of thyroxine in the differentiation of the organ of Corti","volume":"81","author":"M S Deol","year":"1976","journal-title":"Acta Otolaryngol"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0006-8993(80)90840-9","article-title":"The effect of hypothyroidism on the onset of cochlear potentials in developing rats","volume":"182","author":"A Uziel","year":"1980","journal-title":"Brain Res"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1210\/en.2011-1834","article-title":"Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones","volume":"153","author":"E A Cordas","year":"2012","journal-title":"Endocrinology"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1542\/peds.2006-0915","article-title":"Update of newborn screening and therapy for congenital hypothyroidism","volume":"117","author":"S R Rose","year":"2006","journal-title":"Pediatrics"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000509775","article-title":"High prevalence of hearing impairment in primary congenital hypothyroidism","volume":"10","author":"T Almagor","year":"2021","journal-title":"Eur Thyroid J"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1044\/jshr.3003.311","article-title":"Auditory brainstem responses from graduates of an intensive care nursery: normal patterns of response","volume":"30","author":"M P Gorga","year":"1987","journal-title":"J Speech Hear Res"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1044\/jshr.3202.281","article-title":"Auditory brainstem responses from children three months to three years of age: normal patterns of response. II","volume":"32","author":"M P Gorga","year":"1989","journal-title":"J Speech Hear Res"},{"issue":"09","key":"ref14","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1210\/jc.2001-011995","article-title":"Discordance of monozygotic twins for thyroid dysgenesis: implications for screening and for molecular pathophysiology","volume":"87","author":"R Perry","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/MOP.0b013e32834726a4","article-title":"Genetic causes of congenital hypothyroidism due to dyshormonogenesis","volume":"23","author":"H Grasberger","year":"2011","journal-title":"Curr Opin Pediatr"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.beem.2013.05.008","article-title":"Screening for congenital hypothyroidism: a worldwide view of strategies","volume":"28","author":"G Ford","year":"2014","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"05","key":"ref17","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1590\/2359-3997000000292","article-title":"Mechanisms involved in hearing disorders of thyroid ontogeny: a literature review","volume":"61","author":"C LO Andrade","year":"2017","journal-title":"Arch Endocrinol Metab"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.beem.2017.04.011","article-title":"Pendred syndrome","volume":"31","author":"J L W\u00e9meau","year":"2017","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1089\/thy.2013.0164","article-title":"Analysis of the thyroid phenotype in 42 patients with Pendred syndrome and nonsyndromic enlargement of the vestibular aqueduct","volume":"24","author":"M Ladsous","year":"2014","journal-title":"Thyroid"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1210\/jc.2016-2531","article-title":"Mutations in TBL1X are associated with central hypothyroidism","volume":"101","author":"C A Heinen","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"110597","DOI":"10.1016\/j.ijporl.2020.110597","article-title":"Hearing outcome in infants following correction of maternal hypothyroidism during pregnancy","volume":"142","author":"S A Mohiyuddin","year":"2021","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.joto.2020.09.003","article-title":"Congenital hypothyroidism as a risk factor for hearing and parents' knowledge about its impact on hearing","volume":"16","author":"H Braga","year":"2021","journal-title":"J Otol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"110367","DOI":"10.1016\/j.ijporl.2020.110367","article-title":"Long-term evaluation of development in patients with bilateral microtia using softband bone conducted hearing devices","volume":"138","author":"Y Fan","year":"2020","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"09","key":"ref24","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1210\/jc.2013-1645","article-title":"Factors associated with hearing impairment in patients with congenital hypothyroidism treated since the neonatal period: a national population-based study","volume":"98","author":"L Lichtenberger-Geslin","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.heares.2015.04.018","article-title":"Even in the era of congenital hypothyroidism screening mild and subclinical sensorineural hearing loss remains a relatively common complication of severe congenital hypothyroidism","volume":"327","author":"R Bruno","year":"2015","journal-title":"Hear Res"},{"issue":"07","key":"ref26","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1177\/088307380201700707","article-title":"Auditory brainstem evoked potentials in early-treated congenital hypothyroidism","volume":"17","author":"Y H Chou","year":"2002","journal-title":"J Child Neurol"},{"issue":"S 01","key":"ref27","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s12070-018-1395-3","article-title":"Audiological evaluation in hypothyroid patients and effect of thyroxine replacement therapy","volume":"71","author":"R Singh","year":"2019","journal-title":"Indian J Otolaryngol Head Neck Surg"}],"container-title":["Journal of the American Academy of 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