{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:46:58Z","timestamp":1790628418052,"version":"4.1.0"},"reference-count":98,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"JSPS KAKENHI","award":["23K08455"],"award-info":[{"award-number":["23K08455"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Two phenotypes of disseminated intravascular coagulation (DIC) are systematically reviewed. DIC is classified into thrombotic and fibrinolytic phenotypes characterized by thrombosis and hemorrhage, respectively. Major pathology of DIC with thrombotic phenotype is the activation of coagulation, insufficient anticoagulation with endothelial injury, and plasminogen activator inhibitor-1-mediated inhibition of fibrinolysis, leading to microvascular fibrin thrombosis and organ dysfunction. DIC with fibrinolytic phenotype is defined as massive thrombin generation commonly observed in any type of DIC, combined with systemic pathologic hyperfibrinogenolysis caused by underlying disorder that results in severe bleeding due to excessive plasmin formation. Three major pathomechanisms of systemic hyperfibrinogenolysis have been considered: (1) acceleration of tissue-type plasminogen activator (t-PA) release from hypoxic endothelial cells and t-PA-rich storage pools, (2) enhancement of the conversion of plasminogen to plasmin due to specific proteins and receptors that are expressed on cancer cells and endothelial cells, and (3) alternative pathways of fibrinolysis. DIC with fibrinolytic phenotype can be diagnosed by DIC diagnosis followed by the recognition of systemic pathologic hyperfibrin(ogen)olysis. Low fibrinogen levels, high fibrinogen and fibrin degradation products (FDPs), and the FDP\/D-dimer ratio are important for the diagnosis of systemic pathologic hyperfibrin(ogen)olysis. Currently, evidence-based treatment strategies for DIC with fibrinolytic phenotypes are lacking. Tranexamic acid appears to be one of the few methods to be effective in the treatment of systemic pathologic hyperfibrin(ogen)olysis. International cooperation for the elucidation of pathomechanisms, establishment of diagnostic criteria, and treatment strategies for DIC with fibrinolytic phenotype are urgent issues in the field of thrombosis and hemostasis.<\/jats:p>","DOI":"10.1055\/a-2165-1142","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T19:06:20Z","timestamp":1693595180000},"page":"181-191","source":"Crossref","is-referenced-by-count":28,"title":["Phenotypes of Disseminated Intravascular Coagulation"],"prefix":"10.1055","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5220-3342","authenticated-orcid":false,"given":"Takeshi","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Division of Acute and Critical Care Medicine, Hokkaido University Faculty of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3525-0750","authenticated-orcid":false,"given":"Satoshi","family":"Gando","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Division of Acute and Critical Care Medicine, Hokkaido University Faculty of Medicine, Sapporo, Japan"},{"name":"Department of Acute and Critical Care Medicine, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"ref1","first-page":"1571","volume-title":"Consumptive thrombohemorrhagic disorders","author":"V J Marder","year":"2006","edition":"5th ed."},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1055\/s-0037-1616068","article-title":"Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation","volume":"86","author":"F B Taylor Jr","year":"2001","journal-title":"Thromb Haemost"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"16037","DOI":"10.1038\/nrdp.2016.37","article-title":"Disseminated intravascular coagulation","volume":"2","author":"S Gando","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"18","key":"ref4","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1056\/NEJM198905043201802","article-title":"Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects","volume":"320","author":"A F Suffredini","year":"1989","journal-title":"N Engl J Med"},{"issue":"08","key":"ref5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1001\/jama.1993.03510080079035","article-title":"Pathogenesis of disseminated intravascular coagulation in sepsis","volume":"270","author":"M Levi","year":"1993","journal-title":"JAMA"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1055\/s-2001-18867","article-title":"Fibrinolysis in disseminated intravascular coagulation","volume":"27","author":"C E Hack","year":"2001","journal-title":"Semin Thromb Hemost"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1055\/s-0033-1334140","article-title":"Role of fibrinolysis in sepsis","volume":"39","author":"S Gando","year":"2013","journal-title":"Semin Thromb Hemost"},{"issue":"08","key":"ref8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/jth.14480","article-title":"Disseminated intravascular coagulation in cardiac arrest and resuscitation","volume":"17","author":"S Gando","year":"2019","journal-title":"J Thromb Haemost"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1097\/00003246-199511000-00009","article-title":"Cytokines and plasminogen activator inhibitor-1 in posttrauma disseminated intravascular coagulation: relationship to multiple organ dysfunction syndrome","volume":"23","author":"S Gando","year":"1995","journal-title":"Crit Care Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.12688\/f1000research.12498.1","article-title":"Recent advances in pathophysiology of disseminated intravascular coagulation: the role of circulating histones and neutrophil extracellular traps","volume":"6","author":"Y Alhamdi","year":"2017","journal-title":"F1000 Res"},{"issue":"13","key":"ref11","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1182\/blood.2020007208","article-title":"Disseminated intravascular coagulation and its immune mechanisms","volume":"139","author":"N I Popescu","year":"2022","journal-title":"Blood"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1182\/blood.V99.10.3637","article-title":"Tissue-type plasminogen activator (t-PA) is stored in Weibel-Palade bodies in human endothelial cells both in vitro and in vivo","volume":"99","author":"D Huber","year":"2002","journal-title":"Blood"},{"issue":"08","key":"ref13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.tcm.2005.09.005","article-title":"Regulation of Weibel-Palade body exocytosis","volume":"15","author":"C J Lowenstein","year":"2005","journal-title":"Trends Cardiovasc Med"},{"issue":"02","key":"ref14","first-page":"243","article-title":"Human tissue-type plasminogen activator","volume":"112","author":"E K Kruithof","year":"2014","journal-title":"Thromb Haemost"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1111\/jth.13849","article-title":"Fibrinolysis: from blood to the brain","volume":"15","author":"R L Medcalf","year":"2017","journal-title":"J Thromb Haemost"},{"key":"ref16","first-page":"314","volume-title":"BN. Plasminogen activation and regulation of fibrinolysis","author":"N J Mutch","year":"2013"},{"issue":"04","key":"ref17","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/jth.13957","article-title":"Measuring fibrinolysis: from research to routine diagnostic assays","volume":"16","author":"C Longstaff","year":"2018","journal-title":"J Thromb Haemost"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/jth.13261","article-title":"Structure-function relationships in thrombin-activatable fibrinolysis inhibitor","volume":"14","author":"T Plug","year":"2016","journal-title":"J Thromb Haemost"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"649122","DOI":"10.3389\/fimmu.2021.649122","article-title":"Thromboplasminflammation in COVID-19 coagulopathy: three viewpoints for diagnostic and therapeutic strategies","volume":"12","author":"S Gando","year":"2021","journal-title":"Front Immunol"},{"issue":"15","key":"ref20","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1073\/pnas.0608647104","article-title":"Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation","volume":"104","author":"C Kannemeier","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"B Engelmann","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/rth2.12162","article-title":"Polyphosphate in thrombosis, hemostasis, and inflammation","volume":"3","author":"C J Baker","year":"2018","journal-title":"Res Pract Thromb Haemost"},{"issue":"03","key":"ref23","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1172\/JCI110482","article-title":"Leukocyte elastase release during blood coagulation. A potential mechanism for activation of the alternative fibrinolytic pathway","volume":"69","author":"E F Plow","year":"1982","journal-title":"J Clin Invest"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1182\/blood.V86.3.1056.1056","article-title":"The cleavage and inactivation of plasminogen activator inhibitor type 1 by neutrophil elastase: the evaluation of its physiologic relevance in fibrinolysis","volume":"86","author":"K Wu","year":"1995","journal-title":"Blood"},{"issue":"05","key":"ref25","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1182\/blood.V95.5.1721.005k13_1721_1728","article-title":"A monoclonal antibody specific to the granulocyte-derived elastase-fragment D species of human fibrinogen and fibrin: its application to the measurement of granulocyte-derived elastase digests in plasma","volume":"95","author":"I Kohno","year":"2000","journal-title":"Blood"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0049-3848(95)00161-J","article-title":"Impaired clot lysis in the presence of human neutrophil elastase","volume":"80","author":"E T Bach-Gansmo","year":"1995","journal-title":"Thromb Res"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"14270","DOI":"10.1096\/fj.201901363RRR","article-title":"DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma","volume":"33","author":"D BD Cruz","year":"2019","journal-title":"FASEB J"},{"issue":"01","key":"ref28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13054-015-0735-x","article-title":"Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and traumatic shock","volume":"19","author":"S Gando","year":"2015","journal-title":"Crit Care"},{"issue":"01","key":"ref29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/2052-0492-2-20","article-title":"Classifying types of disseminated intravascular coagulation: clinical and animal models","volume":"2","author":"H Asakura","year":"2014","journal-title":"J Intensive Care"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12959-016-0116-y","article-title":"Disseminated intravascular coagulation with the fibrinolytic phenotype predicts the outcome of patients with out-of-hospital cardiac arrest","volume":"14","author":"T Wada","year":"2016","journal-title":"Thromb J"},{"issue":"05","key":"ref31","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.thromres.2009.06.034","article-title":"Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortality","volume":"124","author":"A Sawamura","year":"2009","journal-title":"Thromb Res"},{"issue":"05","key":"ref32","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1177\/1076029612443305","article-title":"Efficacy of recombinant human soluble thrombomodulin in severe postpartum hemorrhage with disseminated intravascular coagulation","volume":"19","author":"J Sugawara","year":"2013","journal-title":"Clin Appl Thromb Hemost"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000205392","article-title":"Characterization of the fibrinolytic state by measuring stable cross-linked fibrin degradation products in disseminated intravascular coagulation associated with acute promyelocytic leukemia","volume":"81","author":"K Okajima","year":"1989","journal-title":"Acta Haematol"},{"issue":"01","key":"ref34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/SLA.0b013e31821221b1","article-title":"Trauma, shock, and disseminated intravascular coagulation: lessons from the classical literature","volume":"254","author":"S Gando","year":"2011","journal-title":"Ann Surg"},{"issue":"05","key":"ref35","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1055\/s-0040-1715795","article-title":"Hyperfibrinolysis in patients with solid malignant neoplasms: a systematic review","volume":"47","author":"A Winther-Larsen","year":"2021","journal-title":"Semin Thromb Hemost"},{"issue":"02","key":"ref36","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neuropharm.2011.10.020","article-title":"tPA in the injured central nervous system: different scenarios starring the same actor?","volume":"62","author":"S Lemarchant","year":"2012","journal-title":"Neuropharmacology"},{"issue":"01","key":"ref37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/bjh.14255","article-title":"Bleeding related to disturbed fibrinolysis","volume":"175","author":"K Kolev","year":"2016","journal-title":"Br J Haematol"},{"issue":"02","key":"ref38","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1172\/JCI118440","article-title":"Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation","volume":"97","author":"D J Pinsky","year":"1996","journal-title":"J Clin Invest"},{"issue":"02","key":"ref39","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.surg.2015.04.008","article-title":"Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock","volume":"158","author":"H B Moore","year":"2015","journal-title":"Surgery"},{"issue":"06","key":"ref40","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0741-5214(93)90548-Z","article-title":"Ambient oxygen tension modulates endothelial fibrinolysis","volume":"18","author":"J P Gertler","year":"1993","journal-title":"J Vasc Surg"},{"issue":"05","key":"ref41","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1172\/JCI307","article-title":"Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition","volume":"102","author":"D J Pinsky","year":"1998","journal-title":"J Clin Invest"},{"issue":"03","key":"ref42","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1096\/fj.06-6285com","article-title":"Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1alpha, and C\/EBPalpha","volume":"21","author":"H Liao","year":"2007","journal-title":"FASEB J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.thromres.2019.07.013","article-title":"The stimulation of thrombosis by hypoxia","volume":"181","author":"N Gupta","year":"2019","journal-title":"Thromb Res"},{"issue":"04","key":"ref44","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.jtha.2022.11.036","article-title":"Acute obstetric coagulopathy during postpartum hemorrhage is caused by hyperfibrinolysis and dysfibrinogenemia: an observational cohort study","volume":"21","author":"L de Lloyd","year":"2023","journal-title":"J Thromb Haemost"},{"issue":"02","key":"ref45","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1182\/blood.V69.2.460.460","article-title":"Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors","volume":"69","author":"E K Kruithof","year":"1987","journal-title":"Blood"},{"issue":"02","key":"ref46","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1055\/s-0038-1655953","article-title":"Massive fibrin formation with consecutive impairment of fibrinolysis in patients with out-of-hospital cardiac arrest","volume":"77","author":"S Gando","year":"1997","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref47","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.1038\/s41598-021-87685-y","article-title":"Fibrinogen may aid in the early differentiation between amniotic fluid embolism and postpartum haemorrhage: a retrospective chart review","volume":"11","author":"S Matsunaga","year":"2021","journal-title":"Sci Rep"},{"issue":"11","key":"ref48","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1097\/CCM.0000000000001273","article-title":"Asphyxia by drowning induces massive bleeding due to hyperfibrinolytic disseminated intravascular coagulation","volume":"43","author":"M Schwameis","year":"2015","journal-title":"Crit Care Med"},{"issue":"05","key":"ref49","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1097\/00001721-199410000-00009","article-title":"The coagulopathy of heat stroke: alterations in coagulation and fibrinolysis in heat stroke patients during the pilgrimage (Haj) to Makkah","volume":"5","author":"S A al-Mashhadani","year":"1994","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"04","key":"ref50","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/CCM.0b013e3182387bef","article-title":"Tissue factor\/factor VIIa pathway mediates coagulation activation in induced-heat stroke in the baboon","volume":"40","author":"A Bouchama","year":"2012","journal-title":"Crit Care Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40560-019-0359-3","article-title":"Successful treatment for disseminated intravascular coagulation (DIC) corresponding to phenotype changes in a heat stroke patient","volume":"7","author":"H Matsumoto","year":"2019","journal-title":"J Intensive Care"},{"issue":"16","key":"ref52","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1182\/blood-2014-08-588442","article-title":"Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice","volume":"125","author":"N Hijazi","year":"2015","journal-title":"Blood"},{"issue":"01","key":"ref53","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s13054-017-1811-1","article-title":"Hyperfibrinolysis in severe isolated traumatic brain injury may occur without tissue hypoperfusion: a retrospective observational multicentre study","volume":"21","author":"M Hayakawa","year":"2017","journal-title":"Crit Care"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"767637","DOI":"10.3389\/fmed.2021.767637","article-title":"Pathophysiology of coagulopathy induced by traumatic brain injury is identical to that of disseminated intravascular coagulation with hyperfibrinolysis","volume":"8","author":"T Wada","year":"2021","journal-title":"Front Med (Lausanne)"},{"issue":"01","key":"ref55","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13054-017-1808-9","article-title":"Disseminated intravascular coagulation with increased fibrinolysis during the early phase of isolated traumatic brain injury","volume":"21","author":"T Wada","year":"2017","journal-title":"Crit Care"},{"issue":"01","key":"ref56","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1227\/00006123-198407000-00008","article-title":"Clinicopathological correlations of disseminated intravascular coagulation in patients with head injury","volume":"15","author":"H H Kaufman","year":"1984","journal-title":"Neurosurgery"},{"issue":"04","key":"ref57","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1385\/NCC:1:4:479","article-title":"Coagulopathy in traumatic brain injury","volume":"1","author":"S C Stein","year":"2004","journal-title":"Neurocrit Care"},{"issue":"06","key":"ref58","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/SHK.0000000000000161","article-title":"Elevated tissue plasminogen activator and reduced plasminogen activator inhibitor promote hyperfibrinolysis in trauma patients","volume":"41","author":"J C Cardenas","year":"2014","journal-title":"Shock"},{"issue":"02","key":"ref59","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12028-022-01647-4","article-title":"Coagulopathy in isolated traumatic brain injury: myth or reality","volume":"38","author":"R Mathur","year":"2023","journal-title":"Neurocrit Care"},{"issue":"03","key":"ref60","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/MBC.0000000000000040","article-title":"Tissue-type plasminogen activator-induced fibrinolysis is enhanced in patients with breast, lung, pancreas and colon cancer","volume":"25","author":"V G Nielsen","year":"2014","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"06","key":"ref61","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1055\/s-2007-999047","article-title":"The fibrinolytic system in neoplasia","volume":"22","author":"W R Bell","year":"1996","journal-title":"Semin Thromb Hemost"},{"issue":"09","key":"ref62","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2298\/VSP150525076K","article-title":"Primary hyperfibrinolysis as the presenting sign of prostate cancer: a case report","volume":"73","author":"A Kuli\u0107","year":"2016","journal-title":"Vojnosanit Pregl"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/1752-1947-6-378","article-title":"Severe bleeding tendency caused by a rare complication of excessive fibrinolysis with disseminated intravascular coagulation in a 51-year-old Japanese man with prostate cancer: a case report","volume":"6","author":"Y Wada","year":"2012","journal-title":"J Med Case Rep"},{"issue":"12","key":"ref64","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.2741\/3550","article-title":"The urokinase receptor as an entertainer of signal transduction","volume":"14","author":"S D'Alessio","year":"2009","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"10","key":"ref65","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1007\/s00345-019-03038-5","article-title":"Expression of urokinase-type plasminogen activator system in non-metastatic prostate cancer","volume":"38","author":"S Kimura","year":"2020","journal-title":"World J Urol"},{"issue":"25","key":"ref66","doi-asserted-by":"crossref","first-page":"14779","DOI":"10.1074\/jbc.271.25.14779","article-title":"Functional analysis of the cellular receptor for urokinase in plasminogen activation. Receptor binding has no influence on the zymogenic nature of pro-urokinase","volume":"271","author":"V Ellis","year":"1996","journal-title":"J Biol Chem"},{"issue":"01","key":"ref67","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12185-013-1463-0","article-title":"Pathogenesis of disseminated intravascular coagulation in patients with acute promyelocytic leukemia, and its treatment using recombinant human soluble thrombomodulin","volume":"100","author":"T Ikezoe","year":"2014","journal-title":"Int J Hematol"},{"issue":"04","key":"ref68","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1055\/s-0033-1334143","article-title":"Annexin A2 system in human biology: cell surface and beyond","volume":"39","author":"M Luo","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"353687","DOI":"10.1155\/2012\/353687","article-title":"The biochemistry and regulation of S100A10: a multifunctional plasminogen receptor involved in oncogenesis","volume":"2012","author":"P A Madureira","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1242\/jcs.00434","article-title":"Thrombin induces endothelial cell-surface exposure of the plasminogen receptor annexin 2","volume":"116","author":"E A Peterson","year":"2003","journal-title":"J Cell Sci"},{"issue":"10","key":"ref71","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1182\/blood-2011-03-341214","article-title":"Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice","volume":"118","author":"B Huang","year":"2011","journal-title":"Blood"},{"issue":"42","key":"ref72","doi-asserted-by":"crossref","first-page":"43411","DOI":"10.1074\/jbc.M408078200","article-title":"An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface","volume":"279","author":"A B Deora","year":"2004","journal-title":"J Biol Chem"},{"issue":"11","key":"ref73","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1001\/archsurg.1983.01390110010002","article-title":"Preoperative disseminated intravascular coagulation associated with aortic aneurysms. A prospective study of 76 cases","volume":"118","author":"D F Fisher Jr","year":"1983","journal-title":"Arch Surg"},{"issue":"06","key":"ref74","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0950-821X(05)80715-7","article-title":"In vivo demonstration of focal fibrinolytic activity in abdominal aortic aneurysms","volume":"7","author":"N Tromholt","year":"1993","journal-title":"Eur J Vasc Surg"},{"issue":"01","key":"ref75","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0741-5214(97)70333-1","article-title":"Elevations of tissue-type plasminogen activator and differential expression of urokinase-type plasminogen activator in diseased aorta","volume":"25","author":"P K Shireman","year":"1997","journal-title":"J Vasc Surg"},{"issue":"03","key":"ref76","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s12185-009-0410-6","article-title":"Expression of annexin II in experimental abdominal aortic aneurysms","volume":"90","author":"T Hayashi","year":"2009","journal-title":"Int J Hematol"},{"issue":"02","key":"ref77","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.surg.2010.06.010","article-title":"Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase","volume":"149","author":"M Hayakawa","year":"2011","journal-title":"Surgery"},{"issue":"06","key":"ref78","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1055\/s-0037-1613942","article-title":"Elastase mediated fibrinolysis in acute promyelocytic leukemia","volume":"83","author":"E J Oudijk","year":"2000","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref79","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1097\/CCM.0000000000000217","article-title":"C1 esterase inhibitor activity in amniotic fluid embolism","volume":"42","author":"N Tamura","year":"2014","journal-title":"Crit Care Med"},{"issue":"07","key":"ref80","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/ccr3.316","article-title":"Therapeutic application of C1 esterase inhibitor concentrate for clinical amniotic fluid embolism: a case report","volume":"3","author":"Y Todo","year":"2015","journal-title":"Clin Case Rep"},{"issue":"01","key":"ref81","doi-asserted-by":"crossref","first-page":"11031","DOI":"10.1038\/s41598-021-90492-0","article-title":"Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients","volume":"11","author":"T Wada","year":"2021","journal-title":"Sci Rep"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jcrc.2017.12.003","article-title":"Prognostic significance of disseminated intravascular coagulation in patients with heat stroke in a nationwide registry","volume":"44","author":"T Hifumi","year":"2018","journal-title":"J Crit Care"},{"issue":"09","key":"ref83","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1182\/blood.V91.9.3093","article-title":"The impact of all-trans-retinoic acid on the coagulopathy of acute promyelocytic leukemia","volume":"91","author":"T Barbui","year":"1998","journal-title":"Blood"},{"issue":"04","key":"ref84","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/jth.12155","article-title":"Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines","volume":"11","author":"H Wada","year":"2013","journal-title":"J Thromb Haemost"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0140-6736(11)60278-X","article-title":"The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial","volume":"377","author":"I Roberts","year":"2011","journal-title":"Lancet"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/S0140-6736(19)32233-0","article-title":"Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial","volume":"394","author":"CRASH-3 trial collaborators","year":"2019","journal-title":"Lancet"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0140-6736(17)30638-4","article-title":"Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial","volume":"389","author":"WOMAN Trial 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Care"},{"issue":"02","key":"ref94","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1365-2141.2005.05750.x","article-title":"All-trans retinoic acid-induced downregulation of annexin II expression in myeloid leukaemia cell lines is not confined to acute promyelocytic leukaemia","volume":"131","author":"S A Olwill","year":"2005","journal-title":"Br J Haematol"},{"issue":"09","key":"ref95","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41419-018-0954-6","article-title":"Regulation of cell surface protease receptor S100A10 by retinoic acid therapy in acute promyelocytic leukemia (APL)\u2606","volume":"9","author":"R W Holloway","year":"2018","journal-title":"Cell Death Dis"},{"issue":"07","key":"ref96","first-page":"1113","article-title":"Fatal thromboembolism in acute promyelocytic leukemia during all-trans retinoic acid therapy combined with antifibrinolytic therapy for prophylaxis of hemorrhage","volume":"8","author":"S 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