{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:13:27Z","timestamp":1780319607815,"version":"3.54.1"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Einf\u00fchrung Depressionen sind h\u00e4ufig und zeigen bei einem Drittel\n                    der F\u00e4lle einen therapieresistenten und chronifizierten Verlauf. Die\n                    invasive Vagusnervstimulation (VNS) ist eine langfristige\n                    Zusatzbehandlungsoption, die in den letzten Jahren zunehmend h\u00e4ufig\n                    angewandt wird. Eine CE-Zertifizierung f\u00fcr die Behandlung der\n                    chronischen und therapierefrakt\u00e4ren Depression besteht seit 2001.\n                    Methoden Basierend auf einer systematischen Literaturrecherche geben wir in\n                    diesem narrativen Review einen \u00dcberblick mit klinischem Schwerpunkt\n                    \u00fcber die invasive VNS als Behandlungsoption bei der Depressionen.\n                    Ergebnisse Nach psychiatrischer Indikationsstellung und Aufkl\u00e4rung wird\n                    in einem kurzen operativen Eingriff der Impulsgeber im Bereich der linken Brust\n                    implantiert. Die Einstellung der Stimulationsparameter erfolgt\n                    ambulant-psychiatrisch in den ersten Wochen nach der OP. Das VNS-System wird\n                    zun\u00e4chst in 3-, sp\u00e4ter in 6-monatigen Intervallen kontrolliert.\n                    Die Stimulation erfolgt f\u00fcr 30 Sekunden zwischen 5-min\u00fctigen\n                    Intervallen. Stimulationssynchrone Heiserkeit ist die h\u00e4ufigste\n                    Nebenwirkung. Steigerung noradrenerger und serotonerger Transmission im Gehirn\n                    und anti-inflammatorische Effekte werden als Wirkmechanismen diskutiert. Der\n                    Behandlungseffekt tritt verz\u00f6gert nach 6\u201312 Monaten ein. Die\n                    kumulative Responserate nach 5 Jahren liegt f\u00fcr die VNS plus\n                    Standardbehandlung bei ca. 67,6% im Vergleich zu 40.9% bei\n                    Standardbehandlung ohne VNS. Langfristige positive Effekte auf\n                    Lebensqualit\u00e4t, Kognition, Morbidit\u00e4t und Mortalit\u00e4t\n                    wurden beschrieben. Schlussfolgerung Die VNS ist eine langfristige, sichere\n                    Behandlungsoption bei schwer betroffenen Depressionspatienten mit positivem\n                    Effekt auf Symptomschwere, Lebensqualit\u00e4t und kognitive Funktion.<\/jats:p>","DOI":"10.1055\/a-2165-7860","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T19:09:20Z","timestamp":1699902560000},"page":"510-516","source":"Crossref","is-referenced-by-count":2,"title":["Vagusnervstimulation (VNS) als Behandlungsoption f\u00fcr\n                    Depressionen"],"prefix":"10.1055","volume":"93","author":[{"given":"Erhan","family":"Kavakbasi","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychische Gesundheit, Universit\u00e4tsklinikum\n                    M\u00fcnster, Universit\u00e4t M\u00fcnster, M\u00fcnster,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard T.","family":"Baune","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychische Gesundheit, Universit\u00e4tsklinikum\n                    M\u00fcnster, Universit\u00e4t M\u00fcnster, M\u00fcnster,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"G S Malhi","year":"2018","journal-title":"Lancet Lond Engl"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/da.22968","article-title":"Defining treatment-resistant depression","volume":"37","author":"B N Gaynes","year":"2020","journal-title":"Depress Anxiety"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jad.2021.11.042","article-title":"Chronic vs non-chronic depression in psychiatric inpatient 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