{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:15:50Z","timestamp":1789420550784,"version":"build-2803163510"},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Resistin, a diminutive secretory adipokine, has been linked to obesity and its\n                    related ailments. A growing body of evidence suggests that resistin may also be\n                    related to the pathogenesis preeclampsia. However, results of previous studies\n                    were not consistent. We performed a systematic review and meta-analysis to\n                    evaluate the level of circulating resistin in women with PE. A systematic search\n                    of Medline, Web of Science, and Embase databases from inception to April 28,\n                    2023, was conducted to identify studies that compared blood resistin levels in\n                    pregnant women with and without PE. A random-effects model was utilized to pool\n                    the results, accounting for heterogeneity. The present study analyzed eighteen\n                    datasets from sixteen observational studies. The results of the meta-analysis\n                    demonstrated a statistically significant increase in blood resistin levels among\n                    women with PE compared to the control group. (standardized mean\n                    difference=0.35, 95% confidence interval: 0.16 to 0.54,\n                    p&lt;0.001; I2=74%). The findings of the subgroup analysis\n                    indicate that various study characteristics, including study design, timing, and\n                    methods for measuring resistin, matching of body mass index between cases and\n                    controls, and study quality scores did not exert a significant impact on the\n                    outcomes. Nonetheless, it is noteworthy that the diagnostic criteria for PE\n                    employed in the studies included in the analysis may have influenced the results\n                    (p for subgroup difference=0.001). Women with preeclampsia exhibit a\n                    greater concentration of resistin in circulation when compared to healthy\n                    pregnant controls.<\/jats:p>","DOI":"10.1055\/a-2167-0179","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T22:52:40Z","timestamp":1696459960000},"page":"835-845","source":"Crossref","is-referenced-by-count":2,"title":["Association Between Circulating Resistin Level and Preeclampsia: A\n                    Meta-Analysis"],"prefix":"10.1055","volume":"55","author":[{"given":"Xiangyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Hangzhou Linping District\n                    First People\u2019s Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Hangzhou Linping District\n                    First People\u2019s Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Hangzhou Linping District\n                    First People\u2019s Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"ref1","first-page":"1","article-title":"Preeclampsia up to date \u2013 what\u2019s going on?","author":"K Bokuda","year":"2023","journal-title":"Hypertens Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"103968","DOI":"10.1016\/j.jri.2023.103968","article-title":"Preeclampsia in 2023: time for preventing early onset- and term preeclampsia:\n                    The paramount role of gestational weight gain","volume":"158","author":"P Y Robillard","year":"2023","journal-title":"J Reprod 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Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/jwh.2020.8384","article-title":"Cardiovascular health after preeclampsia: patient and provider perspective","volume":"30","author":"E W Seely","year":"2021","journal-title":"J Womens Health (Larchmt)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(20)32335-7","article-title":"Pre-eclampsia","volume":"398","author":"L C Chappell","year":"2021","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"102342","DOI":"10.1016\/j.bpobgyn.2023.102342","article-title":"The epidemiology of obesity in reproduction","volume":"89","author":"B Ahmed","year":"2023","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3390\/biomedicines11051419","article-title":"Adipokines in pregnancy: a systematic review of clinical data","volume":"11","author":"N 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Pregnancy"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.placenta.2014.07.002","article-title":"Placental miR-1301 is dysregulated in early-onset preeclampsia and inversely\n                    correlated with maternal circulating leptin","volume":"35","author":"M S Weedon","year":"2014","journal-title":"Placenta"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3109\/10641955.2014.913615","article-title":"Maternal serum resistin is reduced in first trimester preeclampsia pregnancies\n                    and is a marker of clinical severity","volume":"34","author":"M Christiansen","year":"2015","journal-title":"Hypertens Pregnancy"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"516","DOI":"10.12891\/ceog3076.2016","article-title":"Serum level and placental expression of resistin in pregnancies complicated by\n                    preeclampsia: relationship with disease severity","volume":"43","author":"O 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