{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:44:56Z","timestamp":1788281096097,"version":"build-2803163510"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To assess the correlation between serum fibroblast growth factor 23\n                    (FGF-23)\/Klotho levels and end-stage renal disease (ESRD) in middle-aged\n                    and elderly patients combined with low bone mineral density (BMD). The BMD of\n                    the lumbar vertebrae and femoral neck of 87 patients with ESRD was measured\n                    using a dual-energy X-ray bone densitometer during hospitalisation and the\n                    patients were divided into a normal bone mass group and a low bone mass group.\n                    Haemoglobin, albumin, urea nitrogen, uric acid, creatinine, low-density\n                    lipoprotein cholesterol, alkaline phosphatase, blood calcium, blood phosphorus\n                    and full parathyroid hormone were detected using an automatic biochemical\n                    analyser. The levels of serum FGF-23, Klotho and activated vitamin D in the\n                    patients with ESRD were measured via an enzyme-linked immunosorbent assay. Older\n                    age and decreased serum creatinine levels and serum Klotho levels were\n                    associated with low bone mass. There were significantly more men in normal bone\n                    mass group (n=49, 74.24%) than in low bone mass group\n                    (n=8, 38.10%). The correlation analysis showed that BMD was\n                    negatively correlated with age but positively correlated with serum Klotho. The\n                    binary logistic regression analysis indicated that old age and the decrease in\n                    serum Klotho level were independent risk factors of a low BMD (all\n                    p&lt;0.05). In conclusion, serum Klotho is closely related to BMD changes\n                    in middle-aged and elderly patients with ESRD. A high Klotho level is a\n                    protective factor and is expected to be a marker in reducing bone mineral\n                    metabolism disorders and improving the prognosis of patients with ESRD.<\/jats:p>","DOI":"10.1055\/a-2168-5089","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T22:39:51Z","timestamp":1698187191000},"page":"142-149","source":"Crossref","is-referenced-by-count":7,"title":["The Relationship Between Serum Fibroblast Growth Factor 23 and Klotho\n                    Protein and Low Bone Mineral Density in Middle-Aged and Elderly Patients with\n                    End-Stage Renal Disease"],"prefix":"10.1055","volume":"56","author":[{"given":"Ting","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Hebei University,\n                    Baoding, China"},{"name":"College of Clinical Medicine, Hebei University, Baoding,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicao","family":"He","sequence":"first","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Hebei University,\n                    Baoding, China"},{"name":"College of Clinical Medicine, Hebei University, Baoding,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Hebei University,\n                    Baoding, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Hebei University,\n                    Baoding, China"},{"name":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney\n                    Disease of Hebei Province, Baodind, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Hebei University,\n                    Baoding, China"},{"name":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney\n                    Disease of Hebei Province, Baodind, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Hebei University,\n                    Baoding, China"},{"name":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney\n                    Disease of Hebei Province, Baodind, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2020.05.006","article-title":"KDOQI clinical practice guideline for nutrition in CKD: 2020 Update","volume":"76","author":"T A Ikizler","year":"2020","journal-title":"Am J Kidney Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000514550","article-title":"Global epidemiology of end-stage kidney disease and disparities in kidney\n                    replacement therapy","volume":"52","author":"J S Thurlow","year":"2021","journal-title":"Am J Nephrol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s00223-020-00777-1","article-title":"Chronic kidney disease-mineral and bone disorders: pathogenesis and\n                    management","volume":"108","author":"J B 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disease","volume":"1362","author":"N S Akimbekov","year":"2022","journal-title":"Adv Exp Med Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40001-018-0315-z","article-title":"Correlation of serum levels of fibroblast growth factor 23 and Klotho protein\n                    levels with bone mineral density in maintenance hemodialysis patients","volume":"23","author":"S Zheng","year":"2018","journal-title":"Eur J Med Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2478\/jomb-2019-0002","article-title":"Correlation of Fgf23 and Balp with bone mineral density in hemodialysis\n                    patients","volume":"38","author":"M Bouksila","year":"2019","journal-title":"J Med Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5152\/eurasianjmed.2015.93","article-title":"FGF-23, \u03b1-Klotho gene polymorphism and their relationship with the\n                    markers of bone metabolism in chronic peritoneal dialysis patients","volume":"47","author":"V T Yilmaz","year":"2015","journal-title":"Eurasian J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jsbmb.2017.11.005","article-title":"Mechanisms involved in bone resorption regulated by vitamin D","volume":"177","author":"Y Nakamichi","year":"2018","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3389\/fendo.2020.00592","article-title":"Osteocytic FGF23 and its kidney function","volume":"11","author":"R Agoro","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.kint.2017.02.014","article-title":"Klotho expression in osteocytes regulates bone metabolism and controls bone\n                    formation","volume":"92","author":"H Komaba","year":"2017","journal-title":"Kidney Int"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bone.2016.11.012","article-title":"Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho","volume":"100","author":"S Yamada","year":"2017","journal-title":"Bone"}],"container-title":["Hormone and Metabolic 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