{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:25:43Z","timestamp":1790983543649,"version":"4.1.0"},"reference-count":81,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"crossref","award":["Else-Kr\u00f6ner Hyperaldosteronism Registry 2013_A182,Else-Kr\u00f6ner Hyperaldosteronism Registry 2015_A171,Else-Kr\u00f6ner Hyperaldosteronism Registry 2019_A104"],"award-info":[{"award-number":["Else-Kr\u00f6ner Hyperaldosteronism Registry 2013_A182,Else-Kr\u00f6ner Hyperaldosteronism Registry 2015_A171,Else-Kr\u00f6ner Hyperaldosteronism Registry 2019_A104"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["CRC\/Transregio 205\/2,MA 2186\/14-1"],"award-info":[{"award-number":["CRC\/Transregio 205\/2,MA 2186\/14-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Li Chen is supported by grants from the China Scholarship Council","award":["202106940008"],"award-info":[{"award-number":["202106940008"]}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"crossref","award":["694913"],"award-info":[{"award-number":["694913"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary aldosteronism is an endocrine disorder caused by excessive production of\n                    aldosterone by the adrenal glands, and is recognized as the most important cause\n                    of endocrine hypertension. With specific therapy, this type of hypertension is\n                    potentially curable. In the general population, high salt intake increases the\n                    risk for cardiovascular diseases like stroke. In populations with aldosterone\n                    excess, observational and experimental data suggest that aldosterone-induced\n                    organ damage requires a combination of high dietary salt intake and high plasma\n                    aldosterone, i.e., plasma aldosterone levels inappropriately high for salt\n                    status. Therefore, understanding the relationship between plasma aldosterone\n                    levels and dietary salt intake and the nature of their combined effects is\n                    crucial for developing effective prevention and treatment strategies. In this\n                    review, we present an update on findings about primary aldosteronism and salt\n                    intake and the underlying mechanisms governing their interaction.<\/jats:p>","DOI":"10.1055\/a-2172-7228","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:52:46Z","timestamp":1694213566000},"page":"99-106","source":"Crossref","is-referenced-by-count":8,"title":["Salt and Aldosterone \u2013 Reciprocal and Combined Effects in\n                    Preclinical Models and Humans"],"prefix":"10.1055","volume":"56","author":[{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU\n                    M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Adolf","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU\n                    M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU\n                    M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Schneider","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU\n                    M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1152\/physrev.00011.2014","article-title":"Epithelial sodium transport and its control by aldosterone: The story of our\n                    internal environment revisited","volume":"95","author":"B C Rossier","year":"2015","journal-title":"Physiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00424-022-02694-8","article-title":"Flexible and multifaceted: the plasticity of renin-expressing cells","volume":"474","author":"KA E Broeker","year":"2022","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"ref3","first-page":"260","article-title":"Renin release from isolated juxtaglomerular apparatus depends on macula densa\n                    chloride transport","author":"J N Lorenz","year":"1991","journal-title":"Am J Physiol Ren Fluid Electrolyte Physiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S2213-8587(21)00210-2","article-title":"Diagnosis and treatment of primary aldosteronism","volume":"9","author":"M Reincke","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.117.008281","article-title":"Epigenetic regulation of aldosterone synthase gene by sodium and angiotensin\n                    II","volume":"7","author":"Y Takeda","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1161\/HYPERTENSIONAHA.120.15998","article-title":"Effect of dietary sodium modulation on pig adrenal steroidogenesis and\n                    transcriptome profiles","author":"T Vohra","year":"2020","journal-title":"Hypertension"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1161\/HYPERTENSIONAHA.111.188532","article-title":"Visinin-like 1 is upregulated in aldosterone-producing adenomas with KCNJ5\n                    mutations and protects from calcium-induced apoptosis","volume":"59","author":"T A Williams","year":"2012","journal-title":"Hypertension"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/CIRCRESAHA.116.303587","article-title":"Hypertension: renin-angiotensin-aldosterone system alterations","volume":"116","author":"L Te Riet","year":"2015","journal-title":"Circ Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.112.000018","article-title":"Aldosterone increases early atherosclerosis and promotes plaque inflammation\n                    through a placental growth factor-dependent mechanism","volume":"2","author":"A P McGraw","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e008259","DOI":"10.1161\/JAHA.117.008259","article-title":"Intestinal mineralocorticoid receptor contributes to epithelial sodium\n                    channel\u2013mediated intestinal sodium absorption and blood pressure\n                    regulation","volume":"7","author":"T Nakamura","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/HYPERTENSIONAHA.123.20953","article-title":"Hypertension in primary aldosteronism is initiated by salt-induced increases in\n   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Ohno","year":"2018","journal-title":"Hypertension"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1161\/HYPERTENSIONAHA.120.16440","article-title":"Altered taste perception for sodium chloride in patients with primary\n                    aldosteronism: a prospective cohort study","author":"C Adolf","year":"2021","journal-title":"Hypertension"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1055\/a-1116-2407","article-title":"Salt appetite and its effects on cardiovascular risk in primary\n                    aldosteronism","volume":"52","author":"C Adolf","year":"2020","journal-title":"Horm Metab Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuron.2017.09.014","article-title":"Aldosterone-sensing neurons in the NTS exhibit state-dependent pacemaker\n                    activity and drive sodium appetite via synergy with angiotensin II\n                    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Lacolley","year":"2002","journal-title":"Circulation"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1161\/HYPERTENSIONAHA.118.12342","article-title":"Aldosterone induces vascular damage \u2013 a wave reflection analysis\n                    study","volume":"74","author":"C-S Hung","year":"2019","journal-title":"Hypertension"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e3950","DOI":"10.1210\/clinem\/dgaa566","article-title":"Arterial stiffness is associated with clinical outcome and cardiorenal injury in\n                    lateralized primary aldosteronism","volume":"105","author":"C-K Chan","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1210\/en.2002-220120","article-title":"Selective aldosterone blockade prevents angiotensin II\/salt-induced\n                    vascular inflammation in the rat heart","volume":"143","author":"R 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