{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:01:15Z","timestamp":1781643675354,"version":"3.54.5"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac hypertrophy (CH) is an early marker in the clinical course of heart\n                    failure. Circular RNAs (circRNAs) play important roles in human disease.\n                    However, the role of circ_Larp4b in myocardial hypertrophy has not been studied.\n                    Angiotensin II (Ang II) treated HL-1 cells to induce a CH cell model.\n                    Quantitative real-time polymerase chain reaction was used to detect the\n                    expression of circ_Larp4b, microRNA-298-5p, and myocyte enhancer factor 2\n                    (Mef2c). Western blot detected the protein level of alpha-actinin-2 (ACTN2),\n                    beta-myosin heavy chain (\u03b2-MHC), atrial natriuretic peptide (ANP), and\n                    Mef2c. The relationship between miR-298-5p and circ_Larp4b or Mef2c was verified\n                    by dual-luciferase reporter assay and RNA pull-down assay. Circ_Larp4b and Mef2c\n                    were upregulated in HL-1 cells treated with Ang II. Moreover, circ_Larp4b\n                    down-regulation regulated the progress of CH induced by Ang II. MiR-298-5p was a\n                    target of circ_Larp4b, and Mef2c was a target of miR-298-5p. Overexpressed Mef2c\n                    reversed the cell size inhibited by miR-298-5p in Ang II-induced HL-1 cells.\n                    Circ_Larp4b regulated CH progress by regulating miR-298-5p\/Mef2c\n                    axis.<\/jats:p>","DOI":"10.1055\/a-2172-8171","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:02:27Z","timestamp":1699920147000},"page":"33-40","source":"Crossref","is-referenced-by-count":4,"title":["CircRNA Larp4b\/miR-298-5p\/Mef2c Regulates Cardiac\n                    Hypertrophy Induced by Angiotensin II"],"prefix":"10.1055","volume":"45","author":[{"given":"Qihai","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Soochow\n                    University, Suzhou, China"},{"name":"Department of Cardiology, Baoshan Branch, Shuguang Hospital Affiliated\n                    to Shanghai University of Traditional Chinese Medicine, Shanghai,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiading District Central Hospital Affiliated\n                    Shanghai University of Medicine & Health Sciences, Shanghai,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqun","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiading District Central Hospital Affiliated\n                    Shanghai University of Medicine & Health Sciences, Shanghai,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiading District Central Hospital Affiliated\n                    Shanghai University of Medicine & Health Sciences, Shanghai,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Soochow\n                    University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly","volume":"65","author":"N Frey","year":"2003","journal-title":"Annu Rev Physiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/01.RES.0000077012.11088.BC","article-title":"Phenotyping hypertrophy: eschew obfuscation","volume":"92","author":"G W Dorn","year":"2003","journal-title":"Circ 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