{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T10:27:16Z","timestamp":1742380036803,"version":"3.37.3"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known about axillary node metastasis of medullary thyroid cancer (MTC).\n                    To address this, a comparative study of patients with and without axillary node\n                    metastases of MTC was conducted. Among 1215 consecutive patients with MTC, 482\n                    patients had node-negative MTC and 733 patients node-positive MTC. Among the 733\n                    patients with node-positive MTC, 4 patients (0.5%) had axillary node\n                    metastases, all of which were ipsilateral. Patients with axillary node\n                    metastases had 5.7\u20136.9-fold more node metastases removed, both at the\n                    authors\u2019 institution (medians of 34.5 vs. 5 metastases; p=0.011)\n                    and in total (medians of 57 vs. 10 metastases; p=0.013), developed more\n                    frequently distant metastases (3 of 4 vs. 178 of 729 patients, or 75 vs.\n                    24%; p=0.049), specifically to bone (2 of 4 vs. 67 of 729\n                    patients, or 50 vs. 9%; p=0.046) and brain (1 of 4 vs. 4 of 729\n                    patients, or 25 vs. 0.5%; p=0.027), and more often succumbed to\n                    cancer-specific death (3 of 4 vs. 52 of 729 patients, or 75 vs. 14%;\n                    p=0.005). Altogether, patients with axillary node metastases revealed\n                    4\u20138-fold more node metastases in the ipsilateral lateral neck (medians\n                    of 11 vs. 3 metastases; p=0.021) and in the ipsilateral central neck\n                    (medians of 8 vs. 1 metastases; p=0.079) patients without axillary node\n                    metastases. Cancer-specific survival of patients with vs. patients without\n                    axillary node metastases of MTC was significantly shorter (means of 41 vs. 224\n                    months; plog-rank&lt;0.001). These findings show that patients with\n                    axillary node metastases of MTC have massive metastatic dissemination with poor\n                    survival.<\/jats:p>","DOI":"10.1055\/a-2172-9263","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T22:30:17Z","timestamp":1694298617000},"page":"429-434","source":"Crossref","is-referenced-by-count":1,"title":["Axillary Node Metastases of Medullary Thyroid Cancer: A Hallmark of\n                    Terminal Disease"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6796-079X","authenticated-orcid":false,"given":"Andreas","family":"Machens","sequence":"additional","affiliation":[{"name":"Department of Visceral, Vascular and Endocrine Surgery, Martin Luther\n                    University of Halle-Wittenberg Faculty of Medicine, Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-1950","authenticated-orcid":false,"given":"Kerstin","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Visceral, Vascular and Endocrine Surgery, Martin Luther\n                    University of Halle-Wittenberg Faculty of Medicine, Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Division\n                    of Endocrine Surgery, University of Duisburg-Essen, Faculty of Medicine, Essen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Dralle","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Division\n                    of Endocrine Surgery, University of Duisburg-Essen, Faculty of Medicine, Essen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.surg.2005.06.018","article-title":"Contralateral cervical and mediastinal lymph node metastasis in medullary\n                    thyroid cancer: systemic disease?","volume":"139","author":"A Machens","year":"2006","journal-title":"Surgery"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/bjs.6075","article-title":"Prediction of lateral lymph node metastases in medullary thyroid cancer","volume":"95","author":"A Machens","year":"2008","journal-title":"Br J Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/bjs.4525","article-title":"Prediction of mediastinal lymph node metastasis in medullary thyroid\n                    carcinoma","volume":"91","author":"A Machens","year":"2004","journal-title":"Br J Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/SLA.0b013e318268301d","article-title":"Prognostic impact of N staging in 715 medullary thyroid cancer patients:\n                    proposal for a revised staging system","volume":"257","author":"A Machens","year":"2013","journal-title":"Ann Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/bjs.11444","article-title":"Prediction of biochemical cure in patients with medullary thyroid cancer","volume":"107","author":"A Machens","year":"2020","journal-title":"Br J Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.9738\/INTSURG-D-13-00274.1","article-title":"Medullary carcinoma of the thyroid with axillary metastasis: a case report","volume":"100","author":"M Ozdemir","year":"2015","journal-title":"Int Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.4158\/EP13339.CR","article-title":"Thyroid carcinoma metastases to axillary lymph nodes: report of two rare cases\n                    of papillary and medullary thyroid carcinoma and literature review","volume":"20","author":"A L Cummings","year":"2014","journal-title":"Endocr Pract"},{"key":"ref8","first-page":"295","article-title":"Axillary lymph node metastasis in medullary thyroid carcinoma: a case\n                    report","volume":"29","author":"S Z Rasihashemi","year":"2017","journal-title":"Iran J Otorhinolaryngol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1089\/thy.2014.0335","article-title":"American Thyroid Association guidelines task force on medullary thyroid\n                    carcinoma. 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