{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T17:40:24Z","timestamp":1720028424102},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 4-year-old, spayed female mixed breed dog was presented with large crater-like,\n                    well-demarcated, erosive and ulcerative necrotic lesions of the skin, elevated\n                    body temperature and lethargy, that began 14 days after vaccination and\n                    treatment with fluralaner and milbemycin\/praziquantel. Cytology revealed\n                    severe pyogranulomatous inflammation with moderate numbers of extracellular\n                    microorganisms. Histopathologic examination showed severe multifocal\n                    pyogranulomatous dermatitis and panniculitis with severe dermal edema and severe\n                    neutrophilic exocytosis with band-like infiltration of the lower portion of the\n                    epidermis consistent with pyoderma gangrenosum. Despite intensive\n                    immunosuppressive and antimicrobial therapy and intensive inpatient care, the\n                    dog was euthanized 16 days after admission due to complications with clinical\n                    signs of sepsis, acute dyspnea and thoracic effusion.<\/jats:p>","DOI":"10.1055\/a-2174-6948","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T23:30:31Z","timestamp":1699918231000},"page":"361-367","source":"Crossref","is-referenced-by-count":0,"title":["Extensive fatal Pyoderma gangrenosum in a dog after drug\n                    exposure"],"prefix":"10.1055","volume":"51","author":[{"given":"Laura","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Small Animal Clinic, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Klo\u00df","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Justus Liebig University, Giessen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Henrich","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Justus Liebig University, Giessen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Thom","sequence":"additional","affiliation":[{"name":"Small Animal Clinic, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1111\/j.1365-2133.2011.10565.x","article-title":"Pyoderma gangrenosum: a retrospective review of patient characteristics ,\n                    comorbidities and therapy in 103 patients","volume":"165","author":"A M Binus","year":"2011","journal-title":"Br J 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