{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T04:53:17Z","timestamp":1697604797364},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die endovaskul\u00e4re Revaskularisierung mit Paclitaxel-beschichteten Ballons zur Behandlung der peripheren arteriellen Verschlusskrankheit hat sich im femoropoplitealen Segment als wirksame\n          Therapieoption erwiesen. Der antiproliferative Effekt von Paclitaxel verhindert Restenosen. Im infrapoplitealen Segment dagegen ist die Evidenz derzeit noch widerspr\u00fcchlich. Allerdings gibt\n          es Hinweise auf ein erh\u00f6htes Amputations- und Mortalit\u00e4tsrisiko ab 2 Jahren nach Angioplastie mit Paclitaxel-beschichteten Ballons. Dies k\u00f6nnte auf einen dosisabh\u00e4ngigen zytotoxischen Effekt\n          von Paclitaxel zur\u00fcckzuf\u00fchren sein. Sirolimus-beschichtete Ballons k\u00f6nnten daher eine Alternative sein, weil Sirolimus nicht zytotoxisch, sondern zytostatisch wirkt und damit ein weites\n          therapeutisches Fenster aufweist.<\/jats:p><jats:p>Drei einarmige Pilotstudien (50, 25, bzw. 50 Patient*innen) zeigen, dass die Angioplastie mit Sirolimus-beschichteten Ballons zu vergleichbaren Ergebnissen f\u00fchrt, wie von\n          Paclitaxel-beschichteten Ballons berichtet (Lumenverlust nach 6 Monaten: 0,29\u00a0mm; prim\u00e4re Offenheit nach 12 Monaten: femoropopliteal 79%\u201382%, infrapopliteal 59%; Freiheit von\n          Revaskularisierung der Ziell\u00e4sion nach 12 Monaten: femoropopliteal 83%\u201394%, infrapopliteal 86%). Randomisierte kontrollierte Studien zum Vergleich mit Standard-Ballon Angioplastie und mit\n          Paclitaxel-beschichteten Ballons f\u00fcr die Behandlung von Claudicatio intermittens oder chronischer Gliedma\u00dfen-gef\u00e4hrdender Isch\u00e4mie sind aktiv und werden voraussichtlich ab Mitte 2024 erste\n          Ergebnisse zu Wirksamkeit und Sicherheit liefern.<\/jats:p><jats:p>Diese \u00dcbersichtsarbeit stellt die Ergebnisse der Pilotstudien zur Angioplastie mit Sirolimus-beschichteten Ballons zur Behandlung der peripheren arteriellen Verschlusskrankheit vor und gibt\n          einen \u00dcberblich \u00fcber aktuell laufende randomisierte kontrollierte Studien.<\/jats:p>","DOI":"10.1055\/a-2174-7770","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T04:01:03Z","timestamp":1697515263000},"page":"438-444","source":"Crossref","is-referenced-by-count":0,"title":["Angioplastie mit Sirolimus-beschichtetem Ballon: der neue Standard in der Behandlung der PAVK?"],"prefix":"10.1055","volume":"148","author":[{"given":"Ulf Karl-Martin","family":"Teichgr\u00e4ber","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Diagnostische und Interventionelle Radiologie, Friedrich-Schiller-Universit\u00e4t Jena, Jena, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Ingwersen","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Diagnostische und Interventionelle Radiologie, Friedrich-Schiller-Universit\u00e4t Jena, Jena, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/s0140-6736(13)61249-0","article-title":"Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis","volume":"382","author":"FG Fowkes","year":"2013","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1093\/eurheartj\/ehx095","article-title":"2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering\n          atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries. Endorsed by: the European Stroke Organization (ESO), The Task Force for\n          the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS)","volume":"39","author":"V Aboyans","year":"2018","journal-title":"Eur Heart J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.eclinm.2019.09.004","article-title":"Benefit and risk from paclitaxel-coated balloon angioplasty for the treatment of femoropopliteal artery disease: A systematic review and meta-analysis of randomised controlled trials","volume":"16","author":"C Klumb","year":"2019","journal-title":"EClinicalMedicine"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1055\/s-0043-119895","article-title":"Drug-coated Balloon Angioplasty in Femoropopliteal Arteries \u2013 Is There a Class Effect?","volume":"142","author":"UK Teichgr\u00e4ber","year":"2017","journal-title":"Zentralbl 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