{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T04:21:39Z","timestamp":1748406099865,"version":"3.41.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Alterations in left ventricular (LV) diastolic function following native tissue-preserving aortic valve (AV) procedures have not been systematically investigated. Furthermore, no comparisons have been made between these changes and those observed after prosthetic AV replacement.<\/jats:p><jats:p>\n          Methods\u2003From October 2017 to August 2020, 74 patients aged &lt;65 years were referred to our institution for elective AV surgery. Preoperative and postoperative (i.e., discharge, 3-month and 1-year follow-up) transthoracic echocardiography was analyzed.<\/jats:p><jats:p>\n          Results\u2003Native tissue-preserving surgery was performed in 55 patients (AV repair: n\u2009=\u200942, Ross procedure: n\u2009=\u200913). The remaining 19 patients underwent prosthetic AV replacement. Preoperatively and at discharge, transvalvular hemodynamics and LV diastolic function were comparable in both groups. At 1-year follow-up, native valve (NV) patients showed significantly lower mean transvalvular gradient (7\u2009\u00b1\u20095 vs. 9\u2009\u00b1\u20093\u2009mmHg, p\u2009=\u20090.046) and peak velocity (1.74\u2009\u00b1\u20090.51 vs. 2.26\u2009\u00b1\u20090.96 m\/s, p\u2009=\u20090.004), and significantly better septal e\u2032 (9.1\u2009\u00b1\u20092.7 vs. 7.7\u2009\u00b1\u20092.5\u2009cm\/s, p\u2009=\u20090.043) and lateral e\u2032 (14.7\u2009\u00b1\u20093.1 vs. 11.7\u2009\u00b1\u20093.7\u2009cm\/s, p\u2009=\u20090.001). From preoperatively to 1-year postoperatively, septal and lateral e\u2032 and E\/e\u2032 improved markedly after NV preservation (septal e\u2032: +0.7\u2009cm\/s, p\u2009=\u20090.075; lateral e\u2032: +2.3\u2009cm\/s, p\u2009&lt;\u20090.001; E\/e\u2032: \u22121.5, p\u2009=\u20090.001) but not after AV replacement (septal e\u2032: +0.2\u2009cm\/s, p\u2009=\u20090.809; lateral e\u2032: +0.8\u2009cm\/s, p\u2009=\u20090.574; E\/e\u2032: \u22121.2, p\u2009=\u20090.347). Significant negative linear correlations between postoperative transvalvular gradients and absolute changes in lateral e\u2032 and E\/e\u2032 were detected during follow-up.<\/jats:p><jats:p>\n          Conclusion\u2003Preservation of native tissue in AV surgery results in superior transvalvular hemodynamics compared with prosthetic AV replacement. This may induce faster LV reverse remodeling and may explain more pronounced improvement in LV diastolic function.<\/jats:p>","DOI":"10.1055\/a-2178-0395","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T23:00:41Z","timestamp":1695164441000},"page":"254-263","source":"Crossref","is-referenced-by-count":0,"title":["Hemodynamics and Diastolic Function after Native Aortic Valve Preserving vs. Replacing Surgery"],"prefix":"10.1055","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8057-9555","authenticated-orcid":false,"given":"Theresa","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Medical Center Hamburg-Eppendorf University Heart & Vascular Center, Hamburg, Hamburg, Germany"},{"name":"Department of Cardiothoracic Surgery, University Hospital Augsburg, Augsburg, Bayern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Medical Center Hamburg-Eppendorf University Heart & Vascular Center, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Sinning","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Hamburg-Eppendorf University Heart & Vascular Center, Hamburg, Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Waschki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Hamburg-Eppendorf University Heart & Vascular Center, Hamburg, Hamburg Germany"},{"name":"Department of Internal Medicine, Itzehoe Hospital, Itzehoe, Schleswig-Holstein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Reichenspurner","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Medical Center Hamburg-Eppendorf University Heart & Vascular Center, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evaldas","family":"Girdauskas","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Medical Center Hamburg-Eppendorf University Heart & Vascular Center, Hamburg, Hamburg, Germany"},{"name":"Department of Cardiothoracic Surgery, University Hospital Augsburg, Augsburg, Bayern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3415-3385","authenticated-orcid":false,"given":"Johannes","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Medical Center Hamburg-Eppendorf 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