{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:13:08Z","timestamp":1791364388367,"version":"4.3.1"},"reference-count":79,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deep vein thrombosis (DVT) and pulmonary embolism (PE) are the most common manifestations of venous thromboembolism (VTE). Most DVTs affect the lower-extremity veins. Since the symptoms of DVT are non-specific, a prompt and standardised diagnostic work-up is essential to minimise the risk of PE in the acute phase and to prevent thrombosis progression, post-thrombotic syndrome and VTE recurrence in the long-term. Only recently, the AWMF S2k guidelines on Diagnostics and Therapy of Venous Thrombosis and Pulmonary Embolism have been revised. In the present article, we summarize current evidence and guideline recommendations focusing on lower-extremity DVT (LEDVT). Depending on whether the diagnostic work-up is performed by a specialist in vascular medicine or by a primary care physician, different diagnostic algorithms are presented that combine clinical probability, D-dimer testing and diagnostic imaging. The diagnosis of ipsilateral recurrent DVT poses a particular challenge and is presented in a separate algorithm. Anticoagulant therapy is an essential part of therapy, with current guidelines clearly favouring regimens based on direct oral anticoagulants over the traditional sequential therapy of parenteral anticoagulants and vitamin K antagonists. For most DVTs, a duration of therapeutic-dose anticoagulation of at least 3 to 6 months is considered sufficient, and this raises the question of the risk of VTE recurrence after discontinuation of anticoagulation and the need for secondary prophylaxis in the long-term. Depending on the circumstances and trigger factors that have contributed to the occurrence of DVT, management strategies are presented that allow decision-making taking into account the individual bleeding risk and patient's preferences.<\/jats:p>","DOI":"10.1055\/a-2178-6574","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T22:30:30Z","timestamp":1714516230000},"page":"097-110","source":"Crossref","is-referenced-by-count":21,"title":["Management of Deep Vein Thrombosis: An Update Based on the Revised AWMF S2k Guideline"],"prefix":"10.1055","volume":"44","author":[{"given":"Birgit","family":"Linnemann","sequence":"additional","affiliation":[{"name":"Cardiology III \u2013 Angiology, Department of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Beyer-Westendorf","sequence":"additional","affiliation":[{"name":"Thrombosis Research Unit, Division of Haematology, Department of Medicine I, Carl Gustav Carus University Hospital, University Hospital Carl-Gustav Carus, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Espinola-Klein","sequence":"additional","affiliation":[{"name":"Cardiology III \u2013 Angiology, Department of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja S.","family":"M\u00fchlberg","sequence":"additional","affiliation":[{"name":"Department of Angiology, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver J.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Schleswig - Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Klamroth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Angiology and Haemostaseology, Vivantes Klinikum im Friedrichshain, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"I4","DOI":"10.1161\/01.CIR.0000078468.11849.66","article-title":"The epidemiology of venous thromboembolism","volume":"107","author":"R H White","year":"2003","journal-title":"Circulation"},{"issue":"09","key":"ref2","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/CIRCRESAHA.115.306841","article-title":"Global burden of thrombosis: epidemiologic aspects","volume":"118","author":"A M Wendelboe","year":"2016","journal-title":"Circ Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"d5916","DOI":"10.1136\/bmj.d5916","article-title":"Management of deep vein thrombosis and prevention of post-thrombotic syndrome","volume":"343","author":"R HW Strijkers","year":"2011","journal-title":"BMJ"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jvsv.2012.07.003","article-title":"Post-thrombotic syndrome 3 years after deep venous thrombosis in the Thrombosis and Pulmonary Embolism in Out-Patients (TULIPA) PLUS Registry","volume":"1","author":"V Hach-Wunderle","year":"2013","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"issue":"20","key":"ref5","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1182\/blood-2018-01-785956","article-title":"How I treat the postthrombotic syndrome","volume":"131","author":"A Rabinovich","year":"2018","journal-title":"Blood"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/01.mcp.0000136402.24828.0e","article-title":"Complete compression ultrasound for the diagnosis of venous thromboembolism","volume":"10","author":"S M Schellong","year":"2004","journal-title":"Curr Opin Pulm Med"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/jama.2010.43","article-title":"Risk of deep vein thrombosis following a single negative whole-leg compression ultrasound: a systematic review and meta-analysis","volume":"303","author":"S A Johnson","year":"2010","journal-title":"JAMA"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"e0228788","DOI":"10.1371\/journal.pone.0228788","article-title":"Diagnostic accuracy of three ultrasonography strategies for deep vein thrombosis of the lower extremity: a systematic review and meta-analysis","volume":"15","author":"N Kraaijpoel","year":"2020","journal-title":"PLoS One"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/labmed\/lmw001","article-title":"Widely used types and clinical applications of D-dimer assay","volume":"47","author":"R S Riley","year":"2016","journal-title":"Lab Med"},{"issue":"04","key":"ref11","first-page":"1227","article-title":"Hemostatic activation under anticoagulant treatment: a comparison of unfractionated heparin vs. nadroparin in the treatment of proximal deep vein thrombosis","volume":"82","author":"H Stricker","year":"1999","journal-title":"Thromb Haemost"},{"issue":"08","key":"ref12","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/00365513.2017.1390783","article-title":"Age-adjusted D-dimer cut-off in the diagnostic strategy for deep vein thrombosis: a systematic review","volume":"77","author":"M Nybo","year":"2017","journal-title":"Scand J Clin Lab Invest"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1111\/jth.12419","article-title":"Selective D-dimer testing for the diagnosis of acute deep vein thrombosis: a validation study","volume":"11","author":"T van der Hulle","year":"2013","journal-title":"J Thromb Haemost"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/jth.14718","article-title":"Clinical pre-test probability adjusted versus age-adjusted D-dimer interpretation strategy for DVT diagnosis: a diagnostic individual patient data meta-analysis","volume":"18","author":"S Parpia","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1111\/jth.13524","article-title":"The long-term recurrence risk of patients with unprovoked venous thromboembolism: an observational cohort study","volume":"14","author":"P A Kyrle","year":"2016","journal-title":"J Thromb Haemost"},{"issue":"09","key":"ref16","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1111\/jth.14986","article-title":"Safety of using the combination of the Wells rule and D-dimer test for excluding acute recurrent ipsilateral deep vein thrombosis","volume":"18","author":"L F van Dam","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1538-7836.2011.04254.x","article-title":"Residual vein obstruction to predict the risk of recurrent venous thromboembolism in patients with deep vein thrombosis: a systematic review and meta-analysis","volume":"9","author":"M Carrier","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.thromres.2005.02.011","article-title":"Interobserver agreement on ultrasound measurements of residual vein diameter, thrombus echogenicity and Doppler venous flow in patients with previous venous thrombosis","volume":"117","author":"L-A Linkins","year":"2006","journal-title":"Thromb Res"},{"issue":"08","key":"ref19","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/jth.12301","article-title":"The diagnosis of symptomatic recurrent pulmonary embolism and deep vein thrombosis: guidance from the SSC of the ISTH","volume":"11","author":"W Ageno","year":"2013","journal-title":"J Thromb Haemost"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.thromres.2017.11.004","article-title":"Diagnosis of deep vein thrombosis recurrence: ultrasound criteria","volume":"161","author":"M Maufus","year":"2018","journal-title":"Thromb Res"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ajh.20754","article-title":"Combined D-dimer and clinical probability are useful for exclusion of recurrent deep venous thrombosis","volume":"82","author":"C Aguilar","year":"2007","journal-title":"Am J Hematol"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1111\/j.1538-7836.2007.02455.x","article-title":"D-dimer as an adjunct to compression ultrasonography in patients with suspected recurrent deep vein thrombosis","volume":"5","author":"P Prandoni","year":"2007","journal-title":"J Thromb Haemost"},{"issue":"16","key":"ref23","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1182\/blood.2019004114","article-title":"Magnetic resonance imaging for diagnosis of recurrent ipsilateral deep vein thrombosis","volume":"135","author":"L F van Dam","year":"2020","journal-title":"Blood"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.thromres.2013.08.003","article-title":"Timing of recurrent venous thromboembolism early after the index event: a meta-analysis of randomized controlled trials","volume":"132","author":"B L Limone","year":"2013","journal-title":"Thromb Res"},{"issue":"09","key":"ref25","first-page":"CD004174","article-title":"Compression therapy for prevention of post-thrombotic syndrome","volume":"9","author":"D Appelen","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"21","key":"ref26","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1182\/blood-2018-03-836783","article-title":"Reduced incidence of vein occlusion and postthrombotic syndrome after immediate compression for deep vein thrombosis","volume":"132","author":"E E Amin","year":"2018","journal-title":"Blood"},{"issue":"18","key":"ref27","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1161\/CIR.0000000000000130","article-title":"The postthrombotic syndrome: evidence-based prevention, diagnosis, and treatment strategies: a scientific statement from the American Heart Association","volume":"130","author":"S R Kahn","year":"2014","journal-title":"Circulation"},{"issue":"24","key":"ref28","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa0906598","article-title":"Dabigatran versus warfarin in the treatment of acute venous thromboembolism","volume":"361","author":"S Schulman","year":"2009","journal-title":"N Engl J Med"},{"issue":"07","key":"ref29","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1161\/CIRCULATIONAHA.113.004450","article-title":"Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis","volume":"129","author":"S Schulman","year":"2014","journal-title":"Circulation"},{"issue":"26","key":"ref30","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1007903","article-title":"Oral rivaroxaban for symptomatic venous thromboembolism","volume":"363","author":"R Bauersachs","year":"2010","journal-title":"N Engl J 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elastic compression stockings to prevent the post-thrombotic syndrome: a randomized, controlled trial","volume":"141","author":"P Prandoni","year":"2004","journal-title":"Ann Intern Med"},{"issue":"08","key":"ref38","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/0268355514544781","article-title":"Impact of graduated compression stockings on the prevention of post-thrombotic syndrome - results of a randomized controlled trial","volume":"30","author":"A Jayaraj","year":"2015","journal-title":"Phlebology"},{"issue":"02","key":"ref39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/MBC.0b013e328011f2dd","article-title":"Efficacy of elastic compression stockings used early or after resolution of the edema on recanalization after deep venous thrombosis: the COM.PRE Trial","volume":"18","author":"G Arpaia","year":"2007","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"06","key":"ref40","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1182\/blood-2011-11-391961","article-title":"Thigh-length versus below-knee compression elastic stockings for prevention of the postthrombotic syndrome in patients with proximal-venous thrombosis: a randomized trial","volume":"119","author":"P Prandoni","year":"2012","journal-title":"Blood"},{"issue":"01","key":"ref41","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/S2352-3026(17)30227-2","article-title":"Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial","volume":"5","author":"A J Ten Cate-Hoek","year":"2018","journal-title":"Lancet Haematol"},{"issue":"01","key":"ref42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejvs.2020.09.023","article-title":"Editor's Choice - European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis","volume":"61","author":"S K Kakkos","year":"2021","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"01","key":"ref43","first-page":"CD002783","article-title":"Thrombolytic strategies versus standard anticoagulation for acute deep vein thrombosis of the lower limb","volume":"1","author":"C Broderick","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"issue":"06","key":"ref44","doi-asserted-by":"crossref","first-page":"e545","DOI":"10.1016\/j.chest.2021.07.055","article-title":"Antithrombotic therapy for VTE disease: second update of the CHEST Guideline and Expert Panel Report","volume":"160","author":"S M Stevens","year":"2021","journal-title":"Chest"},{"issue":"04","key":"ref45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)","volume":"41","author":"S V Konstantinides","year":"2020","journal-title":"Eur Heart J"},{"issue":"01","key":"ref46","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1160\/TH13-04-0336","article-title":"Prognostic significance of residual venous obstruction in patients with treated unprovoked deep vein thrombosis: a patient-level meta-analysis","volume":"111","author":"M P Donadini","year":"2014","journal-title":"Thromb Haemost"},{"issue":"17","key":"ref47","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1161\/CIRCULATIONAHA.112.102814","article-title":"Identifying risk factors for venous thromboembolism","volume":"125","author":"R H White","year":"2012","journal-title":"Circulation"},{"issue":"09","key":"ref48","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1111\/j.1538-7836.2008.03055.x","article-title":"Testing for inherited thrombophilia does not reduce the recurrence of venous thrombosis","volume":"6","author":"M Coppens","year":"2008","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref49","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s11239-015-1316-1","article-title":"Guidance for the evaluation and treatment of hereditary and acquired thrombophilia","volume":"41","author":"S M Stevens","year":"2016","journal-title":"J Thromb Thrombolysis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.thromres.2016.11.023","article-title":"Impact of thrombophilia screening on venous thromboembolism management practices","volume":"149","author":"A Garcia-Horton","year":"2017","journal-title":"Thromb Res"},{"issue":"05","key":"ref51","doi-asserted-by":"crossref","first-page":"323","DOI":"10.7326\/0003-4819-149-5-200809020-00007","article-title":"Systematic review: the Trousseau syndrome revisited: should we screen extensively for cancer in patients with venous thromboembolism?","volume":"149","author":"M Carrier","year":"2008","journal-title":"Ann Intern Med"},{"issue":"06","key":"ref52","doi-asserted-by":"crossref","first-page":"410","DOI":"10.7326\/M17-0868","article-title":"Screening for occult cancer in patients with unprovoked venous thromboembolism: a systematic review and meta-analysis of individual patient data","volume":"167","author":"N van Es","year":"2017","journal-title":"Ann Intern Med"},{"issue":"05","key":"ref53","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1158\/1055-9965.EPI-13-1138","article-title":"Venous thromboembolism and cancer risk among elderly adults in the United States","volume":"23","author":"M A Marks","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"01","key":"ref54","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11239-019-01822-z","article-title":"A clinical practice-based evaluation of the RIETE score in predicting occult cancer in patients with venous thromboembolism","volume":"48","author":"A Rosell","year":"2019","journal-title":"J Thromb Thrombolysis"},{"issue":"10","key":"ref55","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.7326\/M21-1094","article-title":"Long-term risk for major bleeding during extended oral anticoagulant therapy for first unprovoked venous thromboembolism: a systematic review and meta-analysis","volume":"174","author":"F Khan","year":"2021","journal-title":"Ann Intern Med"},{"issue":"10","key":"ref56","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1182\/blood.2019001605","article-title":"How I assess and manage the risk of bleeding in patients treated for venous thromboembolism","volume":"135","author":"F A Klok","year":"2020","journal-title":"Blood"},{"issue":"05","key":"ref57","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3892\/etm.2021.10779","article-title":"Prediction of bleeding events using the VTE-BLEED risk score in patients with venous thromboembolism receiving anticoagulant therapy","volume":"22","author":"M C Badescu","year":"2021","journal-title":"Exp Ther Med"},{"issue":"13","key":"ref58","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa1700518","article-title":"Rivaroxaban or aspirin for extended treatment of venous thromboembolism","volume":"376","author":"J I Weitz","year":"2017","journal-title":"N Engl J Med"},{"issue":"12","key":"ref59","doi-asserted-by":"crossref","first-page":"955","DOI":"10.7326\/0003-4819-137-12-200212170-00008","article-title":"Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism","volume":"137","author":"P Prandoni","year":"2002","journal-title":"Ann Intern Med"},{"issue":"03","key":"ref60","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1182\/blood-2008-01-131656","article-title":"Residual vein thrombosis to establish duration of anticoagulation after a first episode of deep vein thrombosis: the Duration of Anticoagulation based on Compression UltraSonography (DACUS) study","volume":"112","author":"S Siragusa","year":"2008","journal-title":"Blood"},{"issue":"02","key":"ref61","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1365-2141.2011.08578.x","article-title":"Residual venous thrombosis as predictive factor for recurrent venous thromboembolism in patients with proximal deep vein thrombosis: a systematic review","volume":"153","author":"M Tan","year":"2011","journal-title":"Br J Haematol"},{"issue":"09","key":"ref62","doi-asserted-by":"crossref","first-page":"577","DOI":"10.7326\/0003-4819-150-9-200905050-00003","article-title":"Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trial","volume":"150","author":"P Prandoni","year":"2009","journal-title":"Ann Intern Med"},{"issue":"03","key":"ref63","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/01.CIR.0000079162.69615.0F","article-title":"Predictive value of D-dimer test for recurrent venous thromboembolism after anticoagulation withdrawal in subjects with a previous idiopathic event and in carriers of congenital thrombophilia","volume":"108","author":"G Palareti","year":"2003","journal-title":"Circulation"},{"issue":"03","key":"ref64","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood-2009-08-237354","article-title":"Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective study","volume":"115","author":"B Cosmi","year":"2010","journal-title":"Blood"},{"issue":"07","key":"ref65","doi-asserted-by":"crossref","first-page":"481","DOI":"10.7326\/0003-4819-149-7-200810070-00008","article-title":"Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism","volume":"149","author":"M Verhovsek","year":"2008","journal-title":"Ann Intern 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