{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T18:19:15Z","timestamp":1764181155607,"version":"3.46.0"},"reference-count":103,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Leberverfettung bei Milchk\u00fchen ist das Ergebnis eines\n                    gest\u00f6rten Gleichgewichts zwischen der Aufnahme von freien\n                    Fetts\u00e4uren (NEFA) in die Leberzellen im Verh\u00e4ltnis zur\n                    Kapazit\u00e4t der Metabolisierung und der limitierten Abgabe als very low\n                    density lipoprotein (VLDL). Die Leberverfettung mit dem Risiko einer Ketose hat\n                    sich aufgrund der prim\u00e4ren Selektion auf Milchleistung ohne ausreichende\n                    Ber\u00fccksichtigung der dieser Leistung zugrundeliegenden Mechanismen\n                    ergeben und weist eine genetische Disposition auf. Mit dem neuen\n                    Relativzuchtwert Gesamt der Deutsch Holstein Friesian K\u00fche wird dieser\n                    Problematik (Ketoserisiko) Rechnung getragen und damit ein genetisch bedingtes\n                    Gesundheitsrisiko best\u00e4tigt.<\/jats:p>\n                  <jats:p>Die ectopische Fettablagerung in der Leber schlie\u00dft eine Reihe von\n                    Reaktionsschritten wie Lipolyse, Aufnahme in die Leberzellen, Metabolisierung\n                    und Abgabe als VLDL ein, die in unterschiedlicher Weise direkt oder indirekt im\n                    Sinne einer Prophylaxe beeinflusst werden k\u00f6nnen. Diese\n                    M\u00f6glichkeiten werden zum besseren Verst\u00e4ndnis\n                    pathophysiologischer Abl\u00e4ufe aufgef\u00fchrt. Es handelt sich um die\n                    Verf\u00fctterung einer glucogenen Di\u00e4t, um kontrollierte\n                    F\u00fctterung w\u00e4hrend der Trockenstehperiode, den Zusatz von Niacin,\n                    Cholin, Carnitin oder eine Reduzierung der metabolischen Belastung. Indirekt\n                    k\u00f6nnen auch die Ma\u00dfnahmen zu Prophylaxe der Ketose in diese\n                    Diskussion einbezogen werden.<\/jats:p>","DOI":"10.1055\/a-2178-8847","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T18:33:01Z","timestamp":1699900381000},"page":"305-313","source":"Crossref","is-referenced-by-count":0,"title":["Die Leberverfettung der Milchkuh: Teil 2"],"prefix":"10.1055","volume":"51","author":[{"given":"Holger","family":"Martens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.tvjl.2007.12.018","article-title":"Production diseases of the transition cow","volume":"176","author":"F Mulligan","year":"2008","journal-title":"Vet J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1055\/a-2066-2596","article-title":"Die Leberverfettung der Milchkuh: Teil 1, Bedeutung von Insulin und der\n                    Wachstumshormon-IGF-1-Achse","volume":"51","author":"H Martens","year":"2023","journal-title":"Tierarztl Prax Ausg G Grosstiere Nutztiere"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.3168\/jds.2021-21031","article-title":"Hepatic triacylglycerol associations with production and health in dairy\n                    cows","volume":"105","author":"K Arshad","year":"2022","journal-title":"J Dairy Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1017\/S0022029904000020","article-title":"Activities of the enzymes of hepatic gluconeogenesis in periparturient cows with\n                    induced fat liver","volume":"71","author":"A Murondoti","year":"2004","journal-title":"J Dairy Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.3168\/jds.S0022-0302(91)78632-3","article-title":"Estimated genetic correlations between disease and yield traits in dairy\n                    cattle","volume":"74","author":"H Simianer","year":"1991","journal-title":"J Dairy Sci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3168\/jds.S0022-0302(95)76651-6","article-title":"Genetic parameters for common health disorders of Holstein","volume":"78","author":"H Uribe","year":"1995","journal-title":"J Dairy Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/0167-5877(84)90012-6","article-title":"Disease, production and culling in Holstein-Friesian cows. II. Age, season and\n                    sire effects","volume":"2","author":"I Dohoo","year":"1984","journal-title":"Prev Vet Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.3168\/jds.S0022-0302(98)75806-0","article-title":"Genetic parameters of health disorders, and relationship with 305-day milk yield\n                    and conformation traits of registered Holstein cows","volume":"81","author":"T Van Dorp","year":"1998","journal-title":"J Dairy Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"9002","DOI":"10.3168\/jds.2021-20227","article-title":"Estimated genetic parameters for all genetically evaluated traits in Canadian\n                    Holsteins","volume":"104","author":"G Oliveira Junior","year":"2021","journal-title":"J Dairy Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.3168\/jds.2007-0965","article-title":"Genetic profile of body energy and blood metabolites traits across lactation in\n                    primiparous Holstein cows","volume":"91","author":"G Oikonomou","year":"2008","journal-title":"J Dairy Sci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1439-0388.2011.00976.x","article-title":"Genetic parameters for energy balance, fat\/protein ratio, body condition\n                    score and disease traits in German Holstein cows","volume":"129","author":"N Buttchereit","year":"2012","journal-title":"Animal Breed. Genet"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.domaniend.2005.05.001","article-title":"To what extend do variabilities in hormones, metabolites and energy intake\n                    explain variability in milk yield?","volume":"29","author":"K Ingvartsen","year":"2005","journal-title":"Dom Anim Endocrinol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1080\/01652176.2017.1354561","article-title":"Disturbed bovine mitochondrial lipid metabolism: a review","volume":"37","author":"J Han van der Kolk","year":"2017","journal-title":"Vet Quart"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"S274","DOI":"10.1016\/j.theriogenology.2007.04.043","article-title":"Effect of dietary energy source on energy balance, metabolites and reproduction\n                    variables in dairy cows in early lactation","volume":"68S","author":"A Van Knegsel","year":"2017","journal-title":"Theriogenology"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.3168\/jds.S0022-0302(99)75486-X","article-title":"Effect of calcium soaps of fatty acids and administration of somatotropin on\n                    milk production, preovulatory follicular development, and plasma and follicular\n                    fluid lipid composition in high yielding dairy cows","volume":"82","author":"U Moallem","year":"1999","journal-title":"J Dairy Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.3168\/jds.S0022-0302(90)78972-2","article-title":"Effects of fat supplementation and immature alfalfa to concentrate ratio on\n                    lactation performance of dairy cattle","volume":"73","author":"M Jerred","year":"1999","journal-title":"J Dairy Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.3168\/jds.S0022-0302(04)70033-8","article-title":"Peripartal propylene glycol supplementation and metabolism, animal health,\n                    fertility, and production in dairy cows","volume":"87","author":"M Hoedemaker","year":"2004","journal-title":"J Dairy Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.3168\/jds.S0022-0302(93)77633-X","article-title":"Effect of prepartum propylene glycol administration on periparturient fatty\n                    liver in dairy cows","volume":"76","author":"V Studer","year":"1993","journal-title":"J Dairy Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1530\/rep.0.1230419","article-title":"Effect of dietary-induce increases in circulating insulin concentrations during\n                    the early postpartum period on reproductive function in dairy cows","volume":"123","author":"J Gong","year":"2002","journal-title":"Reproduction"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.3168\/jds.2006-837","article-title":"Effect of glucogenic vs. lipogenic diets on energy balance, blood metabolites,\n                    and reproduction in primiparous and multiparous dairy cows in early\n                    lactation","volume":"90","author":"A Van Knegsel","year":"2007","journal-title":"J Dairy Sci"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"7761","DOI":"10.3168\/jds.2020-19890","article-title":"Models to predict the risk of subacute ruminal acidosis in dairy cows based on\n                    dietary and cow factors: A meta-analysis","volume":"104","author":"B Khorrami","year":"2012","journal-title":"J Dairy Sci"},{"key":"ref22","first-page":"97","article-title":"A new understanding of the causes of fatty liver in dairy cows","volume":"17","author":"B Ametaj","year":"2005","journal-title":"Adv Dairy Technol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"8380","DOI":"10.3168\/jds.2021-20330","article-title":"Invited review: The influence of immune activation on transition cow health and\n                    performance \u2013 A critical evaluation of traditional dogmas","volume":"104","author":"E Horst","year":"2012","journal-title":"J Dairy Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.3168\/jds.2008-1634","article-title":"Performance and metabolic and endocrine changes with emphasis on glucose\n                    metabolism in high-yielding dairy cows with high and low fat content in liver\n                    after calving","volume":"92","author":"H Hammon","year":"2009","journal-title":"J Dairy Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1017\/S0022029914000107","article-title":"Effects of prepartal body condition score and peripartal energy supply of dairy\n                    cows on postpartal lipolysis, energy balance and ketogenesis: an animal model to\n                    investigate subclinical ketosis","volume":"81","author":"K Schulz","year":"2014","journal-title":"J Dairy Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1017\/S1751731118003385","article-title":"Comparison of performance and metabolism from late pregnancy to early lactation\n                    in dairy cows with elevated v. normal body condition at dry-off","volume":"13","author":"K Schuh","year":"2019","journal-title":"Animal"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.3168\/jds.S0022-0302(92) 77951-X","article-title":"Effect of prepartum dry matter intake on liver triglyceride concentration and\n                    early lactation","volume":"75","author":"S Bertics","year":"1992","journal-title":"J Dairy Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e99757","DOI":"10.1371\/journal. pone.0099757","article-title":"Integrative analyses of hepatic differentially expressed genes and blood\n                    biomarkers during the peripartal period between dairy cows overfed or\n                    restricted-fed energy prepartum","volume":"9","author":"K Shahzad","year":"2014","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"9067","DOI":"10.3168\/jds.2020-18603","article-title":"Comparison of prepartum low-energy or high-energy diets with a 2-diet far-off\n                    and close-up strategy for multiparous and primiparous cows","volume":"103","author":"B Richards","year":"2020","journal-title":"J Dairy Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"9205","DOI":"10.3168\/jds.2020-19055","article-title":"Aspects of transition cow metabolomics-Part I: Effects of a metaphylactic\n                    butaphosphan and cyanocobalamin treatment on the metabolome in liver, blood, and\n                    urine in cows with different liver metabotypes","volume":"104","author":"M Sch\u00e4ren","year":"2021","journal-title":"J Dairy Sci"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev. pharmtox.48.121806. 154910","article-title":"Nicotinic acid: PharmacologicaleEffects and mechanisms of action","volume":"48","author":"A Gille","year":"2008","journal-title":"Ann Rev Pharm Toxicol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3725","DOI":"10.3168\/jds.2006-904.","article-title":"The use of nicotinic acid to induce sustained low plasma non-esterified fatty\n                    acids in feed-restricted Holstein cows","volume":"90","author":"J Pires","year":"2007","journal-title":"J Dairy Sci"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"8004","DOI":"10.3168\/jds.2018-14490","article-title":"Effects of supplementing rumen-protected niacin on fibre composition and\n                    metabolism of skeletal muscle in dairy cows during early lactation","volume":"101","author":"J Zeitz","year":"2018","journal-title":"J Dairy Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"5090","DOI":"10.3168\/jds.2011-4304","article-title":"Effects of encapsulated niacin on metabolism and production of periparturient\n                    dairy cows","volume":"94","author":"S Morey","year":"2011","journal-title":"J Dairy Sci"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.3168\/jds.2011-5096","article-title":"Effect of rumen protected niacin on lipid metabolism, oxidative stress, and\n                    performance of transition cows","volume":"95","author":"K Yuan","year":"2012","journal-title":"J Dairy Sci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.3168\/jds. S0022-0302(89)79326-7","article-title":"Seasonal effects of prepartum and postpartum fat and niacin feeding on lactation\n                    performance and lipid metabolism","volume":"72","author":"T Skaar","year":"1989","journal-title":"J Dairy Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3168\/jds.2018-15232","article-title":"Hepatic transcript profiling in early-lactation dairy cows fed rumen-protected\n                    niacin during the transition from late pregnancy to lactation","volume":"102","author":"R Ringseis","year":"2019","journal-title":"J Dairy Sci"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.3168\/jds.2006-811","article-title":"Dietary l-carnitine affects periparturient nutrient metabolism and lactation in\n                    multiparous cows","volume":"90","author":"D Carlson","year":"2007","journal-title":"J Dairy Sci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3390\/ani10020342","article-title":"Effects of a dietary L-Carnitine supplementation on performance, energy\n                    metabolism and recovery from calving in dairy cows","volume":"10","author":"J Meyer","year":"2020","journal-title":"Animals"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/1745039X. 2017.1421340","article-title":"Regulation of carnitine status in ruminants and efficacy of carnitine\n                    supplementation on performance and health aspects of ruminant livestock: a\n                    review","volume":"72","author":"R Ringseis","year":"2018","journal-title":"Arch Animal Nutr"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"e0171080","DOI":"10.1371\/journal.pone.0171080.","article-title":"Choline and methionine differentially alter methyl carbon metabolism in bovine\n                    neonatal hepatocytes","volume":"12","author":"T Chandler","year":"2018","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.bbalip.2011.09.009","article-title":"Phosphatidylcholine biosynthesis and lipoprotein metabolism","volume":"1821","author":"L Cole","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"5902","DOI":"10.3168\/jds.2017-13973","article-title":"Feeding increasing amounts of ruminally protected choline decreased fatty liver\n                    in non-lactating, pregnant Holstein cows in negative energy status","volume":"101","author":"M Zenobi","year":"2018","journal-title":"J Dairy Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.3168\/jds.2019-17378","article-title":"Effect of prepartum energy intake and supplementation with ruminally protected\n                    choline on the innate and adaptive immunity of multiparous Holstein cows","volume":"103","author":"M Zenobi","year":"2020","journal-title":"J Dairy Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.3168\/jds.2019-17302","article-title":"Responses to rumen-protected choline in transition cows do not depend on\n                    prepartum body condition","volume":"103","author":"J Bollati","journal-title":"J Dairy Sci 203"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3168\/jds.2019-16842","article-title":"Meta-analysis of the effects of supplemental rumen-protected choline during the\n                    transition period on performance and health of parous dairy cows","volume":"103","author":"A Arshad","year":"2020","journal-title":"J Dairy Sci"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1292\/jvms.64.293","article-title":"Relevance of apolipoproteins in the development of fat liver and fat\n                    liver-related peripartum diseases in dairy cows","volume":"64","author":"N Katoh","year":"2002","journal-title":"J Vet Med Sci"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"3882","DOI":"10.3168\/jds.S0022-0302(93)77729-2","article-title":"Etiology of lipid-related metabolic disorders in periparturient dairy cows","volume":"76","author":"R Grummer","year":"1993","journal-title":"J Dairy Sci"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"6470","DOI":"10.3168\/jds.2016-12532","article-title":"The effect of different treatments for early-lactation hyperketonemia on blood\n                    \u03b2-hydroxybutyrate, plasma nonesterified fatty acids, glucose, insulin,\n                    and glucagon in dairy cattle","volume":"100","author":"S Mann","year":"2017","journal-title":"J Dairy Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.3168\/jds.2017-13360","article-title":"The effect of different treatments for early-lactation hyperketonemia on liver\n                    triglycerides, glycogen, and expression of key metabolic enzymes in Dairy\n                    cattle","volume":"101","author":"S Mann","year":"2018","journal-title":"J Dairy Sci"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"10324","DOI":"10.3168\/jds.2021-20265","article-title":"Hepatic effects of rumen-protected branched-chain amino acids with or without\n                    propylene glycol supplementation in dairy cows during early lactation","volume":"104","author":"F Leal Yepes","year":"2021","journal-title":"J Dairy Sci"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3168\/jds.S0022-0302(97)75971-X","article-title":"Effect of method delivery of propylene glycol on plasma metabolites of\n                    feed-restricted cattle","volume":"80","author":"J Christensen","year":"1997","journal-title":"J Dairy Sci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.3168\/jds.2007-0607","article-title":"A Meat-analysis of the effect of Monensin in lactating dairy cattle. Part 1:\n                    Metabolic effects","volume":"91","author":"T Duffield","year":"2008","journal-title":"J Dairy Sci"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1152\/physrev.1990.70.2.567","article-title":"Energy contributions of volatile fatty-acids from the gastrointestinal tract in\n                    various species","volume":"70","author":"E Bergman","year":"1990","journal-title":"Physiol Rev"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"9020","DOI":"10.3168\/jds.2016-12007","article-title":"Effects of monensin on glucose metabolism in transition dairy cows","volume":"100","author":"X Markantonatos","year":"2017","journal-title":"J Dairy Sci"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.3168\/jds.2007-0608","article-title":"A Meat-analysis of the effect of Monensin in lactating dairy cattle. Part 2:\n                    Production effects","volume":"91","author":"T Duffield","year":"2008","journal-title":"J Dairy Sci"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.3168\/jds.2007-0801","article-title":"A Meat-analysis of the effect of Monensin in lactating dairy cattle. Part 2:\n                    Health and reproduction","volume":"91","author":"T Duffield","year":"2008","journal-title":"J Dairy Sci"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.3168\/jds.2020-19414","article-title":"Effects of prepartum diets varying in dietary energy density and Monensin on\n                    early-lactation performance in dairy cows","volume":"104","author":"J Vasquez","year":"2020","journal-title":"J Dairy Sci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.3168\/jds.S0022-0302(06)72530-9","article-title":"Effects of rumen-protected choline and Monensin on milk production and\n                    metabolism of periparturient dairy cows","volume":"89","author":"L Zahra","year":"2006","journal-title":"J Dairy Sci"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.3168\/jds.2014-8821","article-title":"Metabolism of early-lactation dairy cows as affected by dietary starch and\n                    Monensin supplementation","volume":"98","author":"M McCarthy","year":"2015","journal-title":"J Dairy Sci"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.rvsc.2017.06.020","article-title":"Innovative dairy cow management to improve resistance to metabolic and\n                    infectious diseases during the transition period","volume":"116","author":"P Lacasse","year":"2018","journal-title":"Res Vet Sci"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.3168\/jds.2021-20551","article-title":"Reducing milking frequency from twice to once daily as an adjunct treatment for\n                    ketosis in lactating dairy cows \u2013 A randomized controlled trial","volume":"105","author":"M Williamson","year":"2022","journal-title":"J Dairy Sci"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"4513","DOI":"10.3168\/jds.2017-13151","article-title":"A randomized controlled trial on the effect of incomplete milking during early\n                    lactation on ketonemia and body condition loss in Holstein dairy cows","volume":"101","author":"P-A Morin","year":"2018","journal-title":"J Dairy Sci"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.3168\/jds.s0022-0302(80)83111-0","article-title":"Partitioning of nutrients during pregnancy and lactation","volume":"63","author":"D Bauman","year":"1980","journal-title":"J Dairy Sci"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.2527\/jas.2011-4790","article-title":"Triennial Lactation Symposium: A local affair: How the mammary gland adapts to\n                    changes in milking frequency","volume":"90","author":"E Wall","year":"2012","journal-title":"J Animal Sci"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5539\/jas.v12n3p1","article-title":"Transition period of the dairy cow revisited: I. Homeorhesis and its changes by\n                    selection and management","volume":"12","author":"H Martens","year":"2020","journal-title":"J Agric Sci"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"25","DOI":"10.5539\/jas.v12n3p25","article-title":"Transition period of the dairy cow revisited: II. Homeorhetic stimulus and\n                    ketosis with implication for fertility","volume":"12","author":"H Martens","year":"2020","journal-title":"J Agric Sci"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"978","DOI":"10.3390\/ani5040395","article-title":"Metabolic disorders in the transition period indicate that the dairy\n                    cows\u2019 ability to adapt is overstressed","volume":"5","author":"A Sundrum","year":"2015","journal-title":"Animals"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.3168\/jds.S0022-0302(05)72804-6","article-title":"Expression of growth hormone Receptor 1A mRNA is decreased in dairy cows but not\n                    in beef cows at parturition","volume":"88","author":"H Jiang","year":"2005","journal-title":"J Dairy Sci"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/0024-3205(75)90313-6","article-title":"Hormone and metabolic differences between lactating beef and dairy cattle","volume":"16","author":"I Hart","year":"1975","journal-title":"Life Sci"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3168\/jds.2008-1421","article-title":"Somatotropic axis components and nutrient partitioning in genetically diverse\n                    dairy cows management under different feed allowances in a pasture system","volume":"92","author":"M Lucy","year":"2009","journal-title":"J Dairy Sci"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1210\/en.2015-1866.","article-title":"Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves\n                    insulin sensitivity in HFD-fed mice","volume":"157","author":"C Wilson","year":"2016","journal-title":"Endocrinology"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"E113","DOI":"10.3168\/jds.S0022-0302(01)70205-6","article-title":"Changes in the somatotropic axis associated with the initiation of\n                    lactation","volume":"84","author":"M Lucy","year":"2001","journal-title":"J Dairy Sci"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1136\/vr.g4178","article-title":"Managing energy balance in the transition cow","volume":"174","author":"D Barret","year":"2014","journal-title":"Vet Rec"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1136\/vr.102119","article-title":"Relationships between metabolite and IGF1 concentrations with fertility and\n                    production outcomes following left abomasal displacement","volume":"174","author":"N Lyons","year":"2014","journal-title":"Vet Rec"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.3168\/jds.S0022-0302(04)73446-3","article-title":"Invited review: Pathology, aetiology, prevention, and treatment of fat liver in\n                    dairy cows","volume":"87","author":"G Bobe","year":"2004","journal-title":"J Dairy Sci"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"9227","DOI":"10.3168\/jds.2020-19057","article-title":"Aspects of transition cow metabolomics\u2014Part II: Histomorphologic changes\n                    in the liver parenchyma throughout the transition period, in cows with different\n                    liver metabotypes and effects of a metaphylactic butaphosphan and cyanocobalamin\n                    treatment","volume":"104","author":"F Pietsch","year":"2021","journal-title":"J Dairy Sci"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"8380","DOI":"10.3168\/jds.2021-20330","article-title":"Invited review: The influence of immune activation on transition cow health and\n                    performance \u2013 A critical evaluation of traditional dogmas","volume":"104","author":"E Horst","year":"2021","journal-title":"J Dairy Sci"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"8634","DOI":"10.3168\/jds.2014-9246","article-title":"Repeatability of metabolic responses to a nutrient deficiency in early and mid\n                    lactation and implications for robustness of dairy cows","volume":"98","author":"J Gross","year":"2015","journal-title":"J Dairy Sci"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"2804","DOI":"10.3168\/jds.2017-13242","article-title":"Regulation of organic nutrients metabolism during transition from late pregnancy\n                    to early lactation","volume":"73","author":"A Bell","year":"1995","journal-title":"J Animal Sci"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0301-6226(94)90163-5","article-title":"Nutrient metabolism and utilization in the liver","volume":"39","author":"V Danf\u00e6r","year":"1994","journal-title":"Livestock Prod Sci"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1002\/iub.400","article-title":"Gluconeogenesis in dairy cows: the secret of making sweet milk from sour\n                    dough","volume":"62","author":"J Aschenbach","year":"2010","journal-title":"IUBMB Life"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3168\/jds.S0022-0302(06)72124-5","article-title":"Partial feed restriction decreases growth hormone receptor 1A mRNA expression in\n                    postpartum dairy cows","volume":"89","author":"P Radcliff","year":"2006","journal-title":"J Dairy Sci"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.3168\/jds.S0022-0302(03)74002-8","article-title":"Growth hormone (GH) binding and expression of GH receptor 1A mRNA in hepatic\n                    tissue of periparturient dairy cows","volume":"86","author":"R Radcliff","year":"2003","journal-title":"J Dairy Sci"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.3168\/jds.2014-8734","article-title":"The somatotropic axis during the physiological estrus cycle in dairy\n                    heifers\u2014Effect on hepatic expression of GHR and SOCS2","volume":"98","author":"K Mense","year":"2015","journal-title":"J Dairy Sci"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.3168\/jds.S0022-0302(06)72199-3","article-title":"Major advances in applied dairy cattle nutrition","volume":"89","author":"M Eastridge","year":"2006","journal-title":"J Dairy Sci"},{"key":"ref87","first-page":"18","article-title":"Aktualisierung der Futteraufnahme-Sch\u00e4tzformel f\u00fcr\n                    Milchk\u00fche auf Basis des Forschungs\u00acprojektes\n                    \u201eOptiKuh\u201c. Workshop \u201eDie optimale Kuh: gesund,\n                    effizient, umweltgerecht\u201c","author":"L Gruber","journal-title":"eMissionCow\/optiKuh2. 28.-29.09.2021,\n                    Braunschweig"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.3168\/jds.S0022-0302(98)75706-6","article-title":"The effect of enhanced milk yield of dairy cows by frequent milking or suckling\n                    on intake and digestibility of the diet","volume":"81","author":"U Bar-Peled","year":"1998","journal-title":"J Dairy Sci"},{"volume-title":"Multi-trait covariance functions to estimate genetic correlations between milk\n                    yield, dry-matter intake and live during lactation. In J. Oldham, G. Simm, A.\n                    Groen, B. Nielsen, J. Pryce, & T. Lawrence (Eds.). Metabolic stress in\n                    dairy cows. British Society of Animal Science Occasional Publication (1991; No.\n                    24, 247-151). Pencuit","author":"R Veerkamp","doi-asserted-by":"publisher","key":"ref89","DOI":"10.1017\/S1463981500043168"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.3168\/jds.2010-3396","article-title":"Short communication: Genetic relationship among daily energy balance, feed\n                    intake, body condition score, and fat to protein ratio of milk in dairy\n                    cows","volume":"94","author":"N Buttchereit","year":"2011","journal-title":"J Dairy Sci"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.3168\/jds.2012-5407","article-title":"Genetic parameters for energy balance, feed efficiency, and related traits in\n                    Holstein cattle","volume":"93","author":"D Spurlock","year":"2012","journal-title":"J Dairy Sci"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.3168\/jds.2018-15480","article-title":"Analysis of the genetic architecture of energy balance and its major\n                    determinants dry matter intake and energy-corrected milk yield in primiparous\n                    Holstein cows","volume":"102","author":"N Krattenmacher","year":"2019","journal-title":"J Dairy Sci"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1017\/S1751731107657772","article-title":"Towards a biological basis for prediction nutrient partitioning: The dairy cow\n                    as an example","volume":"1","author":"N Friggens","year":"2007","journal-title":"Animal"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0301-6226(00)00161-5","article-title":"Impact of recent research on energy feeding system for dairy cattle","volume":"66","author":"R Agnes","year":"2000","journal-title":"Livestock Prod Sci"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1017\/S1751731113001894","article-title":"er al. Influence of energy and nutrient supply pre- and postpartum on\n                    performance of multiparous Simmental, Brown Swiss and Holstein cows in early\n                    lactation","volume":"8","author":"L Gruber","year":"2014","journal-title":"Animal"},{"key":"ref96","first-page":"307","article-title":"Ist die klassische Leberschutztherapie noch aktuell?","volume":"70","author":"M F\u00fcrll","year":"2015","journal-title":"Tier\u00e4rztliche Umschau"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3168\/jds.S0022-0302(91)78216-7","article-title":"Adenosine and the control of adrenergic regulation of adipose tissue lipolysis\n                    during lactation","volume":"74","author":"R Vernon","year":"1991","journal-title":"J Dairy Sci"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0301-6226(76)90027-0","article-title":"Feed intake regulation: A limiting factor in animal production","volume":"3","author":"C Balch","year":"1976","journal-title":"Livestock Product Sci"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0301-6226(91)90103-W","article-title":"Genetic aspects of feed intake and efficiency in lactating dairy heifers","volume":"29","author":"J Arendonk","year":"1991","journal-title":"Livestock Prod Sci"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.3168\/jds.2013-7185","article-title":"Effect of genetic merit for energy balance on luteal activity and subsequent\n                    reproductive performance in primiparous Holstein-Friesian cows","volume":"97","author":"R Von Leesen","year":"2014","journal-title":"J Dairy Sci"},{"key":"ref102","first-page":"7","article-title":"Herausforderung Futteraufnahme \u2013 \u00dcberlegungen zur Milchkuh von\n                    morgen","volume":"90","author":"M Rodehutscord","year":"2018","journal-title":"Z\u00fcchtungskunde"},{"key":"ref103","first-page":"64","author":"R Vernon","year":"1998","journal-title":"Homeorhesis"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"8076","DOI":"10.3168\/jds.2020-19957","article-title":"Cross-sectional analyses of a national database to determine if superior genetic\n                    merit translates to superior dairy cow performance","volume":"104","author":"S Ring","year":"2021","journal-title":"J Dairy Sci"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe G: Gro\u00dftiere \/ Nutztiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2178-8847.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T18:15:33Z","timestamp":1764180933000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2178-8847"}},"subtitle":["Genetische\n                    Pr\u00e4disposition und Prophylaxe"],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":103,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2023,11,13]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2178-8847","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1220","2567-5834"],"issn-type":[{"type":"print","value":"1434-1220"},{"type":"electronic","value":"2567-5834"}],"subject":[],"published":{"date-parts":[[2023,10]]}}}