{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T22:53:11Z","timestamp":1752101591837},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 50-year-old female Hermann\u2019s tortoise (Testudo hermannii\n                        boettgeri) was presented with anorexia and lethargy. Clinical\n                    examination revealed multiple, visually inconspicuous but indentable areas in\n                    the shell corresponding to osteolysis radiographically. Soft tissue nodules and\n                    osteolytic lesions were also noted in the limbs. Laboratory results revealed\n                    elevated aspartate aminotransferase activity and uric acid concentrations,\n                    hypoglycemia, and hyperphosphatemia. Klebsiella oxytoca was isolated from\n                    a biopsied scutal area, and the biopsy suggested neoplasia. After a short period\n                    of clinical improvement, the animal's condition deteriorated, and it\n                    died. Post mortem computed tomography revealed polyostotic lytic lesions of\n                    multiple bones and the shell with associated soft tissue nodules protruding into\n                    the coelom, and nodular lung lesions. Necropsy, histopathology, and\n                    immunohistochemistry secured a diagnosis of a poorly differentiated,\n                    pan-cytokeratin-positive squamous cell carcinoma with widespread soft tissue and\n                    bone metastases, osteolysis and desmoplasia.<\/jats:p>","DOI":"10.1055\/a-2180-5893","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T23:30:31Z","timestamp":1699918231000},"page":"368-374","source":"Crossref","is-referenced-by-count":2,"title":["Metastasizing squamous cell carcinoma in a 50-year-old Eastern\n                    Hermann\u2018s tortoise (Testudo hermannii boettgeri)"],"prefix":"10.1055","volume":"51","author":[{"given":"Jana","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Justus Liebig University Giessen,\n                    Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Erokhina","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Kleintierkrankheiten, Pattensen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabell","family":"Gletscher","sequence":"additional","affiliation":[{"name":"Tierarztpraxis Bieber, Biebergem\u00fcnd, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Mittenzwei","sequence":"additional","affiliation":[{"name":"Tierarztpraxis Bieber, Biebergem\u00fcnd, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janina","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Justus Liebig University Giessen,\n                    Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Schikowski","sequence":"additional","affiliation":[{"name":"Small Animal Clinic, Surgery, Justus Liebig University Giessen,\n                    Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Cigler","sequence":"additional","affiliation":[{"name":"Institute for Fish and Wildlife Health, Vetsuisse Faculty, University\n                    of Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Henrich","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Justus Liebig University Giessen,\n                    Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.cvex.2004.04.002","article-title":"Reptile neoplasia: a retrospective study of case submissions to a specialty\n                    diagnostic service","volume":"7","author":"M M Garner","year":"2004","journal-title":"Vet Clin North Am Exot Anim Pract"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1201\/9780429154317","volume-title":"Noninfectious Diseases and Pathology of Reptiles. 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