{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:50Z","timestamp":1740126830335,"version":"3.37.3"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction Pregnant women and their offspring represented a vulnerable\n                    patient collective during the Covid-19 pandemic. Beyond the direct effect of\n                    SARS-CoV-2 via vertical transmission, an indirect impact on the fetus can occur\n                    through placental lesions deteriorating placental villous function. We performed\n                    a histopathological analysis of placentas of parturients with SARS-CoV-2\n                    compared to healthy controls.<\/jats:p><jats:p>\n          Methods and materials Between February 2022 and July 2022 we conducted a\n                    prospective case\u2013control study analyzing placental specimens of\n                    parturients with SARS-CoV-2 infection compared to specimens of placentas of\n                    healthy controls. Patient history, Covid-19-specific symptoms, and obstetric\n                    outcomes were recorded. Statistical analysis was performed.<\/jats:p><jats:p>\n          Results During the observation period 71 patients were included with a\n                    gestational age 37 1\/7\u201341 5\/7 weeks. Thirty-six patients\n                    presented with SARS-CoV-2 infection. The control group consisted of 35 patients\n                    and showed no placental abnormalities. Among SARS-CoV-2-positive parturients,\n                    66.7% of placentas of the case group showed histopathological\n                    abnormalities classified as vascular or inflammatory abnormalities.\n                    22.2% of placentas showed acute ischemic infarction areas. 8.3%\n                    of placentas showed subchorionic layered thrombi. There was one case of severe\n                    acute subchorionitis. SARS-CoV-2 increased the risk of placental lesions\n                    significantly (OR 3.000, CI 1.890\u20134.762, p=0.0001). Placental\n                    lesions had no significant impact on perinatal acidosis (OR 0.455, CI\n                    0.044\u20134.667, p=0.498) or number of cesarean sections (OR 2.314,\n                    CI 0.717\u20137.473, p=0.156).<\/jats:p><jats:p>\n          Conclusion SARS-CoV-2 infection during labor and delivery increased the\n                    risk of adverse outcomes. Histopathological analysis indicated that the placenta\n                    as a maternal-fetal interface was affected by SARS-CoV-2, leading to systemic\n                    vasculopathy and inflammation.<\/jats:p>","DOI":"10.1055\/a-2180-7302","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:22:46Z","timestamp":1698970966000},"page":"49-56","source":"Crossref","is-referenced-by-count":2,"title":["Covid-19 during Pregnancy \u2013 Histopathological Lesions of the\n                    Placenta"],"prefix":"10.1055","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-9797","authenticated-orcid":false,"given":"Julia","family":"Kummer","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Vivantes Klinikum im\n                    Friedrichshain, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Ameli","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Vivantes Klinikum im\n                    Friedrichshain, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Jebens","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Vivantes Klinikum im\n                    Friedrichshain, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefine","family":"K\u00f6nigbauer","sequence":"additional","affiliation":[{"name":"Obstetrical Department, Charite Medical Faculty Berlin, Berlin,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Mihajlov","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Vivantes Klinikum im\n                    Friedrichshain, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Kaarina","family":"Nacke","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Vivantes Klinikum im\n                    Friedrichshain, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"My Hanh","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Vivantes Klinikum im\n                    Friedrichshain, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Rickert","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vivantes Klinikum im Friedrichshain, Berlin,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Vivantes Klinikum im\n                    Friedrichshain, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Schellenberg","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Vivantes Klinikum im\n                    Friedrichshain, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Hellmeyer","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Vivantes Klinikum im\n                    Friedrichshain, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan,\n                    China","volume":"395","author":"C Huang","year":"2020","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"m2107","DOI":"10.1136\/bmj.m2107","article-title":"Characteristics and outcomes of pregnant women admitted to hospital with\n                    confirmed SARS-CoV-2 infection in UK: national population based cohort\n                    study","volume":"369","author":"M Knight","year":"2020","journal-title":"BMJ"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1055\/a-1727-9672","article-title":"Prevalence of SARS-CoV-2 in pregnant women assessed by RT-PCR in Franconia,\n                    Germany: First results of the SCENARIO Study (SARS-CoV-2 prEvalence in pregNAncy\n                    and at biRth In FrancOnia)","volume":"82","author":"A Hein","year":"2022","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1055\/a-1365-9262","article-title":"Peripartum Covid-19 pneumonia with severe ARDS \u2013 A case report","volume":"225","author":"J T Maier","year":"2021","journal-title":"Z Geburtshilfe Neonatol"},{"key":"ref6","first-page":"588","article-title":"SARS-CoV-2 infection during pregnancy. 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fortress","volume":"15","author":"J R Robbins","year":"2012","journal-title":"Curr Opin Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"S745","DOI":"10.1016\/j.ajog.2017.11.577","article-title":"Pathophysiology of placental-derived fetal growth restriction","volume":"218","author":"G J Burton","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/ajcp\/aqaa089","article-title":"Placental pathology in COVID-19","volume":"154","author":"E D Shanes","year":"2020","journal-title":"Am J Clin Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/diagnostics11010094","article-title":"The effects of COVID-19 on placenta and pregnancy: what do we know so far?","volume":"11","author":"Y P Wong","year":"2021","journal-title":"Diagnostics 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Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.5858\/arpa.2021-0246-SA","article-title":"Defining severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2)\n                    placentitis","volume":"145","author":"J C Watkins","year":"2021","journal-title":"Arch Pathol Lab Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ajog.2022.10.001","article-title":"SARS-CoV-2 placentitis, stillbirth, and maternal COVID-19 vaccination:\n                    clinical-pathologic correlations","volume":"228","author":"D A Schwartz","year":"2023","journal-title":"Am J Obstet Gynecol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/uog.22047","article-title":"ISUOG consensus statement on rationalization of gynecological ultrasound\n                    services in context of SARS-coV\u20112","volume":"55","author":"T Bourne","year":"2020","journal-title":"Ultrasound Obstet 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Int"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s00129-020-04637-9","article-title":"Schwangerschaft, Geburt und Wochenbett mit SARS-CoV-2 und COVID-19 [Pregnancy,\n                    birth, and puerperium with SARS-CoV-2 and COVID-19]","volume":"53","author":"C Hagenbeck","year":"2020","journal-title":"Gyn\u00e4kologe"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1017\/S0950268822001935","article-title":"Replacement dynamics and the pathogenesis of the Alpha, Delta and Omicron\n                    variants of SARS-CoV-2","volume":"151","author":"T Ward","year":"2022","journal-title":"Epidemiol Infect"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2180-7302.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:10:05Z","timestamp":1730823005000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2180-7302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,2]]},"references-count":32,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,2,8]]},"published-print":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2180-7302","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"type":"print","value":"0948-2393"},{"type":"electronic","value":"1439-1651"}],"subject":[],"published":{"date-parts":[[2023,11,2]]}}}