{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:24:40Z","timestamp":1761715480668,"version":"build-2065373602"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Was ist neu?<\/jats:title>\n                  <jats:p>F\u00fcr die Gicht, die h\u00e4ufigste akut entz\u00fcndliche Gelenk-Erkrankung, gibt es erstmalig deutsche Empfehlungen zur Diagnose und Therapie auf S3-Leitlinien-Niveau.<\/jats:p>\n                  <jats:p>F\u00fcr die Diagnose eines ersten typischen Gichtanfalls im haus\u00e4rztlichen Setting reichen in der Regel \u2013 neben dem typischen klinischen Bild \u2013 anamnestische Angaben sowie ein erh\u00f6hter Serum-Harns\u00e4urewert aus. Die Gicht kann unter Zuhilfenahme des sogenannten Gicht-Kalkulators diagnostiziert werden. F\u00fcr gichtuntypische akute Gelenk-Entz\u00fcndungen kommen im fach\u00e4rztlichen Bereich weitere diagnostische Ma\u00dfnahmen wie die Gelenksonografie, eine Gelenk-Punktion mit mikroskopischem Kristall-Nachweis sowie die Dual-Energy-Computertomografie zum Einsatz.<\/jats:p>\n                  <jats:p>Nach Sicherung der Diagnose gibt es 2 S\u00e4ulen der Gichtbehandlung: zum einen die kurzfristige Akutbehandlung des Anfalls, zum anderen die zielwertorientierte, kausale harns\u00e4uresenkende Therapie. Da Patienten mit Gicht zumeist an weiteren kardiorenal-metabolischen Erkrankungen leiden, ist auch deren Therapie zu optimieren. Neben rezidivierenden Gicht-Entz\u00fcndungen sind diese Komorbidit\u00e4ten letztlich Ursache f\u00fcr eine h\u00f6here Rate an kardiovaskul\u00e4ren Ereignissen und Sterblichkeit (Mortalit\u00e4t). Auch wenn sie f\u00fcr die Gicht nicht prim\u00e4r zugelassen sind, stellt die Gruppe der SGLT2-Hemmer durch ihre urikosurische Nebenwirkung eine m\u00f6gliche Therapie-Option f\u00fcr Patienten mit Gicht und entsprechenden Komorbidit\u00e4ten dar, auch um den Harns\u00e4ure-Zielwert zu erreichen.<\/jats:p>\n                  <jats:p>Durch die Senkung der Harns\u00e4ure und die folgende Mobilisation abgelagerter Harns\u00e4ure-Depots kann es zu Beginn der Therapie zur Ausl\u00f6sung von Gichtanf\u00e4llen kommen. Daher wird in den ersten Wochen bzw. Monaten zu einer Anfallsprophylaxe mit niedrig dosiertem Colchicin oder niedrig dosierten NSAR geraten.<\/jats:p>\n                  <jats:p>Da Patienten mit Gicht h\u00e4ufig an weiteren Erkrankungen leiden und entsprechende Komedikationen ben\u00f6tigen, empfiehlt die S3-Leitlinie f\u00fcr die Patientensicherheit grunds\u00e4tzlich einen Interaktions- und Dosierungscheck der zu beginnenden Therapie.<\/jats:p>","DOI":"10.1055\/a-2180-8346","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:58:13Z","timestamp":1761695893000},"page":"1367-1373","source":"Crossref","is-referenced-by-count":0,"title":["Neues zur Gicht"],"prefix":"10.1055","volume":"150","author":[{"given":"Anne-Kathrin","family":"Tausche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"DocEV.5","DOI":"10.3205\/18dgrh054","article-title":"Prevalence and incidence of gout in Germany","volume":"10","author":"AK Tausche","journal-title":"Ger Med Sci"},{"issue":"08","key":"ref3","doi-asserted-by":"publisher","first-page":"e507","DOI":"10.1016\/S2665-9913(24)00117-6","article-title":"Global, regional, and national burden of gout, 1990\u20132020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021","volume":"6","year":"2024","journal-title":"Lancet Rheumatol"},{"issue":"05","key":"ref5","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.3390\/biomedicines10051012","article-title":"Tumor Lysis Syndrome: An Endless Challenge in Onco-Nephrology","volume":"10","author":"G Lupu\u0219oru","year":"2022","journal-title":"Biomedicines"},{"issue":"16","key":"ref6","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1055\/a-0504-5684","article-title":"Gicht und Calciumpyrophosphat-Dihydrat-Arthropathie (\u201ePseudogicht\u201c) \u2013 ein Update","volume":"143","author":"M Reuss-Borst","year":"2018","journal-title":"Dtsch Med Wochenschr"},{"issue":"12","key":"ref7","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.1007\/s10067-024-07159-0","article-title":"Gout diagnoses uncertain when made by general practitioners without serum uric acid testing: an observational study","volume":"43","author":"H Janssens","year":"2024","journal-title":"Clin Rheumatol"},{"issue":"05","key":"ref8","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00108-021-00987-1","article-title":"Gicht Gout","volume":"62","author":"AK Tausche","year":"2021","journal-title":"Internist (Berl)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1136\/annrheumdis-2014-205304","article-title":"Hyperuricaemia and gout: time for a new staging system?","volume":"73","author":"N Dalbeth","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"03","key":"ref10","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s00393-011-0953-9","article-title":"Die Gicht als Systemerkrankung. 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