{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T16:28:09Z","timestamp":1747326489016},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background and study aims Pan-enteric capsule endoscopy (CE) is\n      an emerging alternative to ileo-colonoscopy for diagnosing Crohn\u2019s disease (CD). However, CE\n      does not offer the opportunity to take biopsies to support the diagnosis. This study examined\n      the additional information obtained with mucosal biopsies and the feasibility of CE as a\n      single diagnostic procedure.<\/jats:p><jats:p>\n            Patients and methods This retrospective study was based on a\n      prospective, blind multicenter trial in which patients with suspected CD were examined with\n      ileo-colonoscopy plus segmental biopsies and CE. Histopathological findings were compared to\n      the result of CE.<\/jats:p><jats:p>\n            Results A total of 107 patients with a complete CE were included\n      in the analysis. CE was consistent with CD in 44 patients (41.1%) and ulcerative colitis in 10\n      patients (9.3%). Histopathology confirmed the result of CE in 39.3% of patients and added new\n      diagnostic information in 6.5% of patients. A CE consistent with CD was histologically\n      confirmed in 20.5% of patients. Biopsies most often showed non-specific inflammation (61.4%).\n      Only one patient with a normal CE had a specific histological diagnosis (microscopic colitis).\n      Biopsies altered the diagnosis of ulcerative colitis to CD in two patients, and in two\n      patients with a normal CE, biopsies showed CD or ulcerative colitis. In one patient with\n      lymphoma in the terminal ileum and cecum, CE was misinterpreted as CD.<\/jats:p><jats:p>\n            Conclusions In patients with suspected CD and an evident result\n      of CE, the additional information obtained from biopsies is limited, and CE as a single\n      diagnostic procedure might be feasible in selected patients. Biopsies are warranted, however,\n      in patients with an atypical endoscopic appearance or suspected malignancy.<\/jats:p>","DOI":"10.1055\/a-2180-9537","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T23:08:20Z","timestamp":1695683300000},"page":"E1005-E1012","source":"Crossref","is-referenced-by-count":1,"title":["Additional information obtained from mucosal biopsies is limited after pan-enteric capsule endoscopy in patients with suspected Crohn\u2019s disease"],"prefix":"10.1055","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct03134586","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Sofia Hjerrild","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gastroenterology, Lillebaelt Hospital, Vejle, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pantea","family":"Zinolabedinbik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gastroenterology, Lillebaelt Hospital, Vejle, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob Broder","family":"Brodersen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gastroenterology, Hospital South West Jutland, Esbjerg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gastroenterology, Hospital South West Jutland, Esbjerg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Kjeldsen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Dam","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gastroenterology, Hospital South West Jutland, Esbjerg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1093\/ecco-jcc\/jjy113","article-title":"ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications","volume":"13","author":"C Maaser","year":"2019","journal-title":"J Crohn Colitis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1055\/a-1973-3796","article-title":"Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy 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