{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:43:27Z","timestamp":1771299807652,"version":"3.50.1"},"reference-count":78,"publisher":"Georg Thieme Verlag KG","issue":"S 01","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Das Plattenepithelkarzinom ist das h\u00e4ufigste Malignom im Bereich der Mundh\u00f6hle,\n                    des Pharynx und des Larynx. Auch im Zeitalter modernster medikament\u00f6ser\n                    Behandlungsverfahren ist und bleibt derzeit die radikale Resektion dieser\n                    Tumoren der therapeutische Goldstandard. Der mit der Operation verbundene\n                    Verlust anatomischer Strukturen verst\u00e4rkt zwangsl\u00e4ufig die durch den Tumor\n                    selbst hervorgerufenen Funktionsst\u00f6rungen. Dabei wird der Umfang der\n                    funktionellen Defizite ma\u00dfgeblich vom Resektionsausma\u00df bestimmt. Komplette\n                    Organresektionen, wie die Glossektomie, die komplette Gaumenresektion, die\n                    Laryngektomie oder die quere Pharyngo- Laryngektomie f\u00fchren zu schwersten\n                    Funktionsausf\u00e4llen, wie St\u00f6rungen des Schluckaktes mit lebensbedrohlichen\n                    Aspirationen und Artikulationsst\u00f6rungen bis hin zur Sprechunf\u00e4higkeit. Mit Hilfe\n                    der plastisch- rekonstruktiven Chirurgie lassen sich der Gewebeverlust ersetzen\n                    und die spezifischen Funktionen des oberen Aerodigestivtraktes erhalten bzw.\n                    wiederherstellen.<\/jats:p><jats:p>In den letzten Jahrzehnten haben sich die rekonstruktiven Operationsverfahren im\n                    Rahmen der Behandlung maligner Tumoren des Kopf- Hals- Bereichs enorm weiter\n                    entwickelt. Um diese optimal zu nutzen, ist ein umfassendes, interdisziplin\u00e4res\n                    Therapiekonzept Voraussetzung f\u00fcr den onkologischen und funktionellen Erfolg.\n                    Dabei spielen neben allgemeinmedizinischen und sozialen vor allem\n                    operationstechnische Parameter die entscheidende Rolle bei der Wahl der\n                    Rekonstruktionsmethode. In wie weit die operativen Ma\u00dfnahmen fach\u00fcbergreifend\n                    erfolgen m\u00fcssen, h\u00e4ngt von der Lokalisation der Defekte im Kopf-Hals-Bereich und\n                    von der Art des ben\u00f6tigten Ersatzgewebes ab. Hierbei kommt neben der Expertise\n                    der HNO-Chirurgen die Expertise der Plastischen Chirurgen, der\n                    Mund-Kiefer-Gesichtschirurgen und der Abdominalchirurgen besonders zum Tragen.\n                    Der Einsatz unterschiedlicher Gewebe, die Kombination verschiedener\n                    Transplantate und Lappen oder die Pr\u00e4formierung von Spenderregionen erm\u00f6glichen\n                    Rekonstruktionen weit \u00fcber das Ma\u00df der alleinigen Wiederherstellung der\n                    Oberfl\u00e4chenintegrit\u00e4t. Die funktionellen Ergebnisse und damit die Lebensqualit\u00e4t\n                    der Patienten nach chirurgischer Therapie ausgedehnter Tumoren der genannten\n                    Lokalisationen h\u00e4ngen entscheidend von der Art der Rekonstruktion ab. Deshalb\n                    wird im nachfolgenden Referat der besondere Schwerpunkt auf die Wahl der\n                    Rekonstruktionsmethode und die Rekonstruktionstechnik bei Gewebeverlusten nach\n                    Resektionen von Plattenepithelkarzinomen im Kopf-Hals-Bereich (HNSCC)\n                    gelegt.<\/jats:p>","DOI":"10.1055\/a-2181-9088","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T22:46:42Z","timestamp":1714690002000},"page":"S3-S27","source":"Crossref","is-referenced-by-count":2,"special_numbering":"S","title":["Interdisziplin\u00e4re Plastische und Rekonstruktive Chirurgie\n                    von Plattenepithelkarzinomen des\n                    Kopf-Hals-Bereichs"],"prefix":"10.1055","volume":"103","author":[{"given":"S.","family":"Remmert","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie\n                    Helios St. Anna-Klinik, Duisburg-Huckingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Sack","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie\n                    Helios St. Anna-Klinik, Duisburg-Huckingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hasenberg","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie\n                    Helios St. Anna-Klinik, Duisburg-Huckingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lehnhardt","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik Plastische Chirurgie und Handchirurgie,\n                    Schwerbrandverletztenzentrum, Sarkomzentrum, BG Universit\u00e4tsklinikum\n                    Bergmannsheil Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Steubing","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik Plastische Chirurgie und Handchirurgie,\n                    Schwerbrandverletztenzentrum, Sarkomzentrum, BG Universit\u00e4tsklinikum\n                    Bergmannsheil Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Puscz","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik Plastische Chirurgie und Handchirurgie,\n                    Schwerbrandverletztenzentrum, Sarkomzentrum, BG Universit\u00e4tsklinikum\n                    Bergmannsheil Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1288\/00005537-199310000-00010","article-title":"Tongue reconstruction: concepts and practice","volume":"103","author":"B H Haughey","year":"1993","journal-title":"Laryngoscope"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1177\/000348949210100206","article-title":"Dysphagia following various of surgical resection for oral cancer","volume":"101","author":"M Hirano","year":"1992","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref3","first-page":"472","article-title":"Verminderte Aspiration nach ausgedehnten tumorchirurgischen Eingriffen im\n                    Bereich von Mundh\u00f6hle und Rachen durch Kehlkopfhochzug","volume":"40","author":"H Maier","year":"1992","journal-title":"HNO"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0196-0709(93)90023-Z","article-title":"Vascularized free-tissue transfer in head and neck surgery","volume":"14","author":"K C Shestak","year":"1993","journal-title":"Am J Otolaryngol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1001\/archotol.1993.01880210033005","article-title":"Total glossectomy with laryngeal preservation","volume":"119","author":"R Tiwari","year":"1993","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/archotol.1994.01880300007002","article-title":"A systematic approach to the functional reconstruction of the oral cavity\n                    following partial and total glossectomy","volume":"120","author":"M L Urken","year":"1994","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1001\/archotol.1981.00790470042010","article-title":"Advanced carcinoma of the tongue. 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