{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:07:28Z","timestamp":1768676848929,"version":"3.49.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Previous studies indicate the renal vasodilating effects of\n                    boldine, an alkaloid found in Peumus boldus. However, its potential to\n                    induce diuresis still needs to be studied.<\/jats:p><jats:p>\n          Methods Wistar rats were used and the urine volume was noted for\n                    8\u2009h and further studied.<\/jats:p><jats:p>\n          Results The acute treatment at 0.1 and 0.3\u2009mg\/kg of\n                    boldine showed a diuretic, natriuretic, and Ca2+-sparing\n                    effect in rats without changing the urinary elimination of\n                    K+and Cl-. When boldine was given in combination\n                    with hydrochlorothiazide, there was an increase in urinary volume compared to\n                    the vehicle group. However, this was not different from the treatments in its\n                    isolated form. Urine Ca2+values \u200b\u200bremained\n                    low but were not enhanced by this association. The excretion of\n                        Na+and Cl- was significantly increased\n                    compared to the group that received only vehicle or boldine. On the other hand,\n                    although the association of amiloride plus boldine did not result in a diuretic\n                    effect, the increase in Na+and the reduction in\n                        K+excretion were significantly potentiated. Furthermore,\n                    in the presence of the non-selective muscarinic receptor antagonist atropine,\n                    boldine showed reduced capacity to increase urinary volume, maintaining the\n                    natriuretic and Ca2+-sparing effect, besides a very evident\n                        K+-sparing action. Similar results were obtained in the\n                    presence of the non-selective cyclooxygenase inhibitor indomethacin.\n                    Furthermore, boldine showed an ex vivo antiurolithiasis activity, reducing\n                    calcium oxalate\u2019s precipitation and crystallization.<\/jats:p><jats:p>\n          Conclusions This study reveals the diuretic, natriuretic,\n                        Ca2+-sparing, and antiurolithiatic effects of boldine, an\n                    action possibly related to muscarinic receptor activation and prostanoid\n                    generation.<\/jats:p>","DOI":"10.1055\/a-2182-3665","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T23:38:34Z","timestamp":1699400314000},"page":"513-519","source":"Crossref","is-referenced-by-count":1,"title":["Diuretic, Natriuretic, And Ca2+-Sparing Effect Of\n                    The Alkaloid Boldine In Rats"],"prefix":"10.1055","volume":"73","author":[{"given":"Viviane Miranda Bispo","family":"Steimbach","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, University of Vale do\n                    Itaja\u00ed (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritade C\u00e1ssia Vilhena","family":"da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, University of Vale do\n                    Itaja\u00ed (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00edsa Nath\u00e1lia Bolda","family":"Mariano","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, University of Vale do\n                    Itaja\u00ed (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Zanovello","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, University of Vale do\n                    Itaja\u00ed (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anelise Fel\u00edcio","family":"Macarini","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, University of Vale do\n                    Itaja\u00ed (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa Mota","family":"da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, University of Vale do\n                    Itaja\u00ed (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-5642","authenticated-orcid":false,"given":"Priscila","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1093\/age\/kwu319.","article-title":"The contribution of genomic research to explaining racial disparities in\n                    cardiovascular disease: a systematic review","volume":"181","author":"J S Kaufman","year":"2015","journal-title":"Am J Epidemiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2.","article-title":"The global epidemiology of hypertension","volume":"16","author":"K T Mills","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1016\/S0140-6736(16)31134-5","article-title":"A call to action and a life course strategy to address the global burden of\n                    raised blood pressure on current and future generations: the Lancet Commission\n                    on hypertension","volume":"388","author":"M H Olsen","year":"2016","journal-title":"Lancet"},{"key":"ref4","volume-title":"Antihypertensive Medications. 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