{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T18:07:02Z","timestamp":1748282822173,"version":"3.37.3"},"reference-count":83,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Handchir Mikrochir Plast Chir"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund Das Lip\u00f6dem bezeichnet eine symmetrisch lokalisierte,\n                    schmerzhafte Vermehrung des subkutanen Fettgewebes an den Extremit\u00e4ten\n                    mit deutlicher Disproportion zum Stamm, von der fast ausschlie\u00dfliche\n                    Frauen betroffen sind. Obwohl die Erstbeschreibung \u00fcber 80 Jahre\n                    zur\u00fcckliegt, sind die \u00c4tiologie und Pathogenese der Erkrankung\n                    bislang weitestgehend ungekl\u00e4rt und zurzeit Inhalt intensiver\n                    Forschungsarbeit.<\/jats:p><jats:p>\n          Methoden Zur Zusammenfassung der aktuellen evidenz-basierten Literatur zur\n                    Pathologie, Pathohistologie und Pathogenese des Lip\u00f6dems erfolgte eine\n                    PRISMA-basierte systematische Literaturrecherche innerhalb der National Library\n                    of Medicine und Cochrane-Datenbank.<\/jats:p><jats:p>\n          Ergebnisse Insgesamt konnten 53 Studien identifiziert und in diese\n                    \u00dcbersicht inkludiert werden. Die Ergebnisse wurden in Kategorien\n                    klassifiziert und zusammengefasst.<\/jats:p><jats:p>\n          Schlussfolgerung Trotz einer deutlichen Zunahme der\n                    Forschungsaktivit\u00e4t und der Ver\u00f6ffentlichung umfangreicher\n                    Studien mit histologischem und molekulargenetischem Schwerpunkt in den letzten\n                    Jahren, bleibt die grundlegende \u00c4tiologie und Pathologie der Erkrankung\n                    Lip\u00f6dem weitestgehend uneindeutig. Die aktuelle Datenlage weist\n                    studien\u00fcbergreifend Diskrepanzen auf, insbesondere die\n                    \u201e\u00f6demat\u00f6se\u201c Komponente des Lip\u00f6dems ist\n                    umstritten. Die h\u00e4ufig-vorliegenden Ko-Morbidit\u00e4ten\n                    \u201eLymph\u00f6dem\u201c und \u201e\u00dcbergewicht\u201c,\n                    vornehmlich in fortgeschrittenen Stadien, erschweren die\n                    differentialdiagnostische Abgrenzung und klare Definition von Studienkohorten in\n                    der wissenschaftlichen Forschung.<\/jats:p>","DOI":"10.1055\/a-2183-7414","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T23:36:47Z","timestamp":1700523407000},"page":"411-426","source":"Crossref","is-referenced-by-count":1,"title":["Auf der Suche nach der Evidenz: Eine systematische\n                    \u00dcbersichtsarbeit zur Pathologie des Lip\u00f6dems"],"prefix":"10.1055","volume":"55","author":[{"given":"Sarah","family":"Funke","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Handchirurgie, Plastische und \u00c4sthetische\n                    Chirurgie, LMU-Klinikum, Ludwig-Maximilians-Universit\u00e4t,\n                    M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8102-1430","authenticated-orcid":false,"given":"Constanze","family":"Kuhlmann","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Handchirurgie, Plastische und \u00c4sthetische\n                    Chirurgie, LMU-Klinikum, Ludwig-Maximilians-Universit\u00e4t,\n                    M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Taha","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Handchirurgie, Plastische und \u00c4sthetische\n                    Chirurgie, LMU-Klinikum, Ludwig-Maximilians-Universit\u00e4t,\n                    M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Handchirurgie, Plastische und \u00c4sthetische\n                    Chirurgie, LMU-Klinikum, Ludwig-Maximilians-Universit\u00e4t,\n                    M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Severin","family":"Wiggenhauser","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Handchirurgie, Plastische und \u00c4sthetische\n                    Chirurgie, LMU-Klinikum, Ludwig-Maximilians-Universit\u00e4t,\n                    M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo E.","family":"Giunta","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Handchirurgie, Plastische und \u00c4sthetische\n                    Chirurgie, LMU-Klinikum, Ludwig-Maximilians-Universit\u00e4t,\n                    M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s40519-019-00703-x","article-title":"The effect of lipedema on health-related quality of life and psychological\n                    status: a narrative review of the literature","volume":"25","author":"N Alwardat","year":"2020","journal-title":"Eat Weight Disord"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3238\/arztebl.2020.0396","article-title":"Lipedema-Pathogenesis, Diagnosis, and Treatment Options","volume":"117","author":"P Kruppa","year":"2020","journal-title":"Dtsch Arztebl Int"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.7326\/0003-4819-34-5-1243","article-title":"Lipedema of the legs; a syndrome characterized by fat legs and edema","volume":"34","author":"L E Wold","year":"1951","journal-title":"Ann Intern Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1046\/j.1439-0353.2004.04051.x","article-title":"Lipoedema \u2013 current status, new perspectives","volume":"2","author":"I Meier-Vollrath","year":"2004","journal-title":"J Dtsch Dermatol Ges"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1111\/j.1365-2133.2009.09413.x","article-title":"Lipoedema: from clinical presentation to therapy. 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