{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:10:20Z","timestamp":1790604620130,"version":"4.1.0"},"reference-count":8,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to investigate whether neonatal morbidity differs in spontaneous compared with indicated preterm births in extremely premature neonates.<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective cohort study including births \u226428 weeks at a single institution from 2011 to 2020. Births were categorized as either medically indicated or spontaneous preterm deliveries. The primary outcome was inhospital mortality and serious morbidity in survivors. t-tests, Fisher's exact tests, chi-square tests, and logistic regression models were utilized as appropriate. p\u2009&lt;\u20090.05 was significant.<\/jats:p><jats:p>\n            Results\u2003Two hundred and twenty-seven births were included, with two-thirds representing spontaneous births (65.6%, 149\/227) and one-third categorized as medically indicated births (34.4%, 78\/227). Inhospital mortality was more common in the spontaneous preterm birth group (p\u2009=\u20090.04), while inhospital morbidity did not significantly vary between the medically indicated and spontaneous birth groups (p\u2009=\u20090.32). There was no difference in inhospital morbidity or mortality by maternal race. In multivariate models of inhospital morbidity and mortality, gestational age was the only significant predictor of adverse outcomes.<\/jats:p><jats:p>\n            Conclusion\u2003Despite inhospital mortality being more common in spontaneous preterm births, inhospital mortality and significant morbidity are best accounted for by gestational age alone.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2184-1374","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:52:40Z","timestamp":1696027960000},"page":"e2985-e2989","source":"Crossref","is-referenced-by-count":2,"special_numbering":"S","title":["The Impact of Spontaneous versus Indicated Preterm Birth on Neonatal Outcomes among Extremely Premature Neonates"],"prefix":"10.1055","volume":"41","author":[{"given":"Courtney","family":"Townsel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Hesson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5000-1819","authenticated-orcid":false,"given":"Nayla G.","family":"Kazzi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Texas-Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie C.","family":"Treadwell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"issue":"9606","key":"ref2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"R L Goldenberg","year":"2008","journal-title":"Lancet"},{"issue":"263","key":"ref3","first-page":"263ed21","article-title":"Preterm birth: now the leading cause of child death worldwide","volume":"6","author":"J E Lawn","year":"2014","journal-title":"Sci Transl Med"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1053\/j.semperi.2017.07.009","article-title":"Epidemiology of preterm birth","volume":"41","author":"S E Purisch","year":"2017","journal-title":"Semin Perinatol"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1055\/s-0037-1608804","article-title":"Neonatal outcomes differ after spontaneous and indicated preterm birth","volume":"35","author":"M J Stout","year":"2018","journal-title":"Am J Perinatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fped.2017.00006","article-title":"Gender differences in respiratory morbidity and mortality of preterm neonates","volume":"5","author":"C D Townsel","year":"2017","journal-title":"Front Pediatr"},{"issue":"03","key":"ref8","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","volume":"19","author":"D Roberts","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/AOG.0b013e3181ae98c2","article-title":"Effects of antenatal exposure to magnesium sulfate on neuroprotection and mortality in preterm infants: a meta-analysis","volume":"114","author":"M M Costantine","year":"2009","journal-title":"Obstet Gynecol"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.clp.2017.01.009","article-title":"Survival of infants born at periviable gestational ages","volume":"44","author":"R M Patel","year":"2017","journal-title":"Clin Perinatol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2184-1374.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:45:47Z","timestamp":1730814347000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2184-1374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":8,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2184-1374","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9,29]]},"published":{"date-parts":[[2023,9,29]]}}}