{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:16:38Z","timestamp":1793031398068,"version":"4.5.0"},"reference-count":67,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Plast Surg"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The etiology and pathophysiology of delayed inflammatory reactions caused by hyaluronic acid fillers have not yet been elucidated. Previous studies have suggested that the etiology can be attributed to the hyaluronic acid filler itself, patient's immunological status, infection, and injection technique. Hyaluronic acid fillers are composed of high-molecular weight hyaluronic acids that are chemically cross-linked using substances such as 1,4-butanediol diglycidyl ether (BDDE). The mechanism by which BDDE cross-links the two hyaluronic acid disaccharides is still unclear and it may exist as a fully reacted cross-linker, pendant cross-linker, deactivated cross-linker, and residual cross-linker. The hyaluronic acid filler also contains impurities such as silicone oil and aluminum during the manufacturing process. Impurities can induce a foreign body reaction when the hyaluronic acid filler is injected into the body. Aseptic hyaluronic acid filler injections should be performed while considering the possibility of biofilm formation or delayed inflammatory reaction. Delayed inflammatory reactions tend to occur when patients experience flu-like illnesses; thus, the patient's immunological status plays an important role in delayed inflammatory reactions. Large-bolus hyaluronic acid filler injections can induce foreign body reactions and carry a relatively high risk of granuloma formation.<\/jats:p>","DOI":"10.1055\/a-2184-6554","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:55:20Z","timestamp":1696028120000},"page":"020-026","source":"Crossref","is-referenced-by-count":27,"title":["Etiology of Delayed Inflammatory Reaction Induced by Hyaluronic Acid Filler"],"prefix":"10.1055","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-0198","authenticated-orcid":false,"given":"Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Yonsei E1 Plastic Surgery Clinic, Scientific Faculty of the Minimal Invasive Plastic Surgery Association, Dongan-ro, Dongan-gu, Anyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Shah-Desai","sequence":"additional","affiliation":[{"name":"Perfect Eyes Ltd, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nark-Kyoung","family":"Rho","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sungkyunkwan University School of Medicine, Gyeonggi-do, Republic of Korea. Leaders Aesthetic Laser & Cosmetic Surgery Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongmok","family":"Cho","sequence":"additional","affiliation":[{"name":"Etonne Plastic Surgery Clinic, Scientific Faculty of the Milimal Invasive Plastic Surgery Association, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"issue":"S 01","key":"ref1","first-page":"1","article-title":"The aesthetic society's cosmetic surgery national data bank: Statistics 2019","volume":"40","year":"2020","journal-title":"Aesthet Surg J"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1177\/1090820X13484492","article-title":"Complications of injectable fillers, part I","volume":"33","author":"C DeLorenzi","year":"2013","journal-title":"Aesthet Surg J"},{"key":"ref3","first-page":"41","volume-title":"Filler-induced hypersensitivity inflammation and granuloma","author":"I S Koh","year":"2019","edition":"1st ed."},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"NP286","DOI":"10.1093\/asj\/sjz222","article-title":"A systematic review of the literature of delayed inflammatory reactions after hyaluronic acid filler injection to estimate the incidence of delayed type hypersensitivity reaction","volume":"40","author":"K L Chung","year":"2020","journal-title":"Aesthet Surg J"},{"issue":"07","key":"ref5","first-page":"752","article-title":"Review of delayed reactions to 15 hyaluronic acid fillers","volume":"48","author":"R E Kokoska","year":"2022","journal-title":"Dermatol Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2147\/CCID.S247171","article-title":"Delayed inflammatory reactions to hyaluronic acid fillers: a literature review and proposed treatment algorithm","volume":"13","author":"O Artzi","year":"2020","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"NP438","DOI":"10.1093\/asj\/sjad028","article-title":"Making sense of late tissue nodules associated with hyaluronic acid injections","volume":"43","author":"G J Goodman","year":"2023","journal-title":"Aesthet Surg J"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1007\/s00266-017-1063-0","article-title":"Treatment of soft tissue filler complications: expert consensus recommendations","volume":"42","author":"F Urdiales-G\u00e1lvez","year":"2018","journal-title":"Aesth Plast Surg"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/DSS.0000000000001202","article-title":"Filler nodules: inflammatory or infectious? A review of biofilms and their implications on clinical practice","volume":"44","author":"O Ibrahim","year":"2018","journal-title":"Dermatol Surg"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"e4362","DOI":"10.1097\/GOX.0000000000004362","article-title":"Treatment of delayed-onset inflammatory reactions to hyaluronic acid filler: an algorithmic approach","volume":"10","author":"D K Funt","year":"2022","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/dsu.12301","article-title":"A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers","volume":"39","author":"K De Boulle","year":"2013","journal-title":"Dermatol Surg"},{"issue":"05","key":"ref12","first-page":"600","article-title":"Effect of different crosslinking technologies on hyaluronic acid behavior: a visual and microscopic study of seven hyaluronic acid gels","volume":"15","author":"P Micheels","year":"2016","journal-title":"J Drugs Dermatol"},{"issue":"09","key":"ref13","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1002\/jbm.a.35437","article-title":"Modulation of biomechanical properties of hyaluronic acid hydrogels by crosslinking agents","volume":"103","author":"S C Choi","year":"2015","journal-title":"J Biomed Mater Res A"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/14764170701774901","article-title":"The science of hyaluronic acid dermal fillers","volume":"10","author":"A Tezel","year":"2008","journal-title":"J Cosmet Laser Ther"},{"issue":"03","key":"ref15","first-page":"2280800019867075","article-title":"HA-based dermal filler: downstream process comparison, impurity quantitation by validated HPLC-MS analysis, and in vivo residence time study","volume":"17","author":"C Guarise","year":"2019","journal-title":"J Appl Biomater Funct Mater"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.carbpol.2015.05.050","article-title":"Determination of modification degree in BDDE-modified hyaluronic acid hydrogel by SEC\/MS","volume":"131","author":"B Yang","year":"2015","journal-title":"Carbohydr Polym"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.carbpol.2016.11.029","article-title":"1D NMR methods for determination of degree of cross-linking and BDDE substitution positions in HA hydrogels","volume":"157","author":"F J Wende","year":"2017","journal-title":"Carbohydr Polym"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.carbpol.2012.08.066","article-title":"Modification and cross-linking parameters in hyaluronic acid hydrogels\u2013definitions and analytical methods","volume":"91","author":"L Kenne","year":"2013","journal-title":"Carbohydr Polym"},{"issue":"07","key":"ref19","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.3390\/polym15071649","article-title":"Determination of hyaluronic acid dermal filler impurities using SEM\/EDS analysis","volume":"15","author":"W Lee","year":"2023","journal-title":"Polymers (Basel)"},{"issue":"03","key":"ref20","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5731\/pdajpst.2013.00922","article-title":"Particulate matter in injectable drug products","volume":"67","author":"S E Langille","year":"2013","journal-title":"PDA J Pharm Sci Technol"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0946-672X(03)80006-8","article-title":"Influence of the glass packing on the contamination of pharmaceutical products by aluminium. Part III: Interaction container-chemicals during the heating for sterilisation","volume":"17","author":"D Bohrer","year":"2003","journal-title":"J Trace Elem Med Biol"},{"issue":"38","key":"ref22","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1016\/j.vaccine.2015.08.006","article-title":"Evaluation of hyaluronic acid-based combination adjuvant containing monophosphoryl lipid A and aluminum salt for hepatitis B vaccine","volume":"33","author":"S H Moon","year":"2015","journal-title":"Vaccine"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1016\/j.xphs.2020.07.012","article-title":"Method to determine syringe silicone oil layer heterogeneity and investigation of its impact on product particle counts","volume":"109","author":"M Cua","year":"2020","journal-title":"J Pharm Sci"},{"issue":"01","key":"ref24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s40942-021-00338-0","article-title":"The risks behind the widespread use of siliconized syringes in the healthcare practice","volume":"7","author":"G B Melo","year":"2021","journal-title":"Int J Retina Vitreous"},{"key":"ref26","volume-title":"European Pharmacopoeia","author":"Pharmaeuropa","year":"2019"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"929531","DOI":"10.1155\/2013\/929531","article-title":"The roles of hyaluronan\/RHAMM\/CD44 and their respective interactions along the insidious pathways of fibrosarcoma progression","volume":"2013","author":"D Nikitovic","year":"2013","journal-title":"BioMed Res Int"},{"issue":"22","key":"ref28","doi-asserted-by":"crossref","first-page":"16667","DOI":"10.1074\/jbc.M702078200","article-title":"The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells","volume":"282","author":"S R Hamilton","year":"2007","journal-title":"J Biol Chem"},{"issue":"18","key":"ref29","doi-asserted-by":"crossref","first-page":"10518","DOI":"10.3390\/ijms231810518","article-title":"The rheology and physicochemical characteristics of hyaluronic acid fillers: their clinical implications","volume":"23","author":"S P Fundar\u00f2","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"07","key":"ref30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1021\/acsbiomaterials.5b00181","article-title":"High and low molecular weight hyaluronic acid differentially influence macrophage activation","volume":"1","author":"J E Rayahin","year":"2015","journal-title":"ACS Biomater Sci Eng"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.2147\/CCID.S363583","article-title":"Current practices in hyaluronic acid dermal filler treatment in Asia Pacific and practical approaches to achieving safe and natural-looking results","volume":"15","author":"N Corduff","year":"2022","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"ref32","first-page":"100065","article-title":"In vitro inflammatory and immune response to uncrosslinked hyaluronic acid (HA) and HA fillers","volume":"17","author":"C K Hee","year":"2022","journal-title":"J Immunol Regen Med"},{"key":"ref33","first-page":"11","volume-title":"Hyaluronic acid filler property and hyaluronidase","author":"W Lee","year":"2022","edition":"1st ed."},{"issue":"01","key":"ref34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s13205-016-0379-9","article-title":"Biotechnological production of hyaluronic acid: a mini review","volume":"6","author":"J H Sze","year":"2016","journal-title":"3 Biotech"},{"key":"ref36","volume-title":"Physical properties and rheological approach for hyaluronic acid fillers","author":"E-J Yang","year":"2022","edition":"1st ed."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/j.1524-4725.2012.02472.x","article-title":"Gel properties of hyaluronic acid dermal fillers","volume":"38","author":"K Edsman","year":"2012","journal-title":"Dermatol Surg"},{"issue":"02","key":"ref38","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"J M Anderson","year":"2008","journal-title":"Semin Immunol"},{"issue":"06","key":"ref39","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1097\/PRS.0b013e31818236d7","article-title":"Foreign body granulomas after all injectable dermal fillers: part 1. Possible causes","volume":"123","author":"G Lemperle","year":"2009","journal-title":"Plast Reconstr Surg"},{"issue":"02","key":"ref40","doi-asserted-by":"crossref","first-page":"232","DOI":"10.5999\/aps.2015.42.2.232","article-title":"Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment","volume":"42","author":"J M Lee","year":"2015","journal-title":"Arch Plast Surg"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2147\/CCID.S198081","article-title":"Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness","volume":"12","author":"M G Turkmani","year":"2019","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"02","key":"ref42","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/jocd.15098","article-title":"No association found between late-onset inflammatory adverse events after soft tissue filler injections and the adaptive immune system","volume":"22","author":"T S Decates","year":"2023","journal-title":"J Cosmet Dermatol"},{"issue":"04","key":"ref43","doi-asserted-by":"crossref","first-page":"e2730","DOI":"10.1097\/GOX.0000000000002730","article-title":"Global approaches to the prevention and management of delayed-onset adverse reactions with hyaluronic acid-based fillers","volume":"8","author":"W G Philipp-Dormston","year":"2020","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"01","key":"ref44","doi-asserted-by":"crossref","first-page":"e14644","DOI":"10.1111\/dth.14644","article-title":"Increased risk of late-onset, immune-mediated, adverse reactions related to dermal fillers in patients bearing HLA-B*08 and DRB1*03 haplotypes","volume":"34","author":"T S Decates","year":"2021","journal-title":"Dermatol Ther"},{"issue":"08","key":"ref45","first-page":"e17055","article-title":"Reporting at least one adverse effect post-COVID-19 vaccination from primary health care in Muscat","volume":"13","author":"T S Al Ghafri","year":"2021","journal-title":"Cureus"},{"issue":"07","key":"ref46","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1111\/jocd.15071","article-title":"A systematic review on COVID-19 vaccination and cosmetic filler reactions: a focus on case studies and original articles","volume":"21","author":"Y Kalantari","year":"2022","journal-title":"J Cosmet Dermatol"},{"issue":"05","key":"ref47","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/jocd.14074","article-title":"Hypersensitivity reaction to Hyaluronic Acid Dermal filler following novel Coronavirus infection - a case report","volume":"20","author":"M J Rowland-Warmann","year":"2021","journal-title":"J Cosmet Dermatol"},{"issue":"05","key":"ref48","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1111\/jocd.14046","article-title":"Delayed hypersensitivity reaction to hyaluronic acid dermal filler post-COVID-19 viral infection","volume":"20","author":"D Shome","year":"2021","journal-title":"J Cosmet Dermatol"},{"issue":"01","key":"ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00403-021-02190-6","article-title":"\u201cCOVID-19\/SARS-CoV-2 virus spike protein-related delayed inflammatory reaction to hyaluronic acid dermal fillers: a challenging clinical conundrum in diagnosis and treatment\u201d","volume":"314","author":"G G Munavalli","year":"2022","journal-title":"Arch Dermatol Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijid.2021.09.066","article-title":"Hypersensitivity reaction to hyaluronic acid dermal filler after the Pfizer vaccination against SARS-CoV-2","volume":"113","author":"D Savva","year":"2021","journal-title":"Int J Infect Dis"},{"issue":"01","key":"ref51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jaad.2021.04.073","article-title":"July 2021: Lisinopril for delayed inflammatory responses to hyaluronic acid fillers after COVID-19 vaccinations","volume":"85","author":"B Sloan","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jdcr.2021.02.018","article-title":"Oral angiotensin-converting enzyme inhibitors for treatment of delayed inflammatory reaction to dermal hyaluronic acid fillers following COVID-19 vaccination-a model for inhibition of angiotensin II-induced cutaneous inflammation","volume":"10","author":"G G Munavalli","year":"2021","journal-title":"JAAD Case Rep"},{"issue":"01","key":"ref53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/PSN.0000000000000087","article-title":"Dermal fillers in aesthetics: an overview of adverse events and treatment approaches","volume":"35","author":"D Funt","year":"2015","journal-title":"Plast Surg Nurs"},{"issue":"12","key":"ref54","doi-asserted-by":"crossref","first-page":"e1532","DOI":"10.1097\/GOX.0000000000001532","article-title":"Late-onset inflammatory response to hyaluronic acid dermal fillers","volume":"5","author":"T Bhojani-Lynch","year":"2017","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"03","key":"ref55","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/PRS.0000000000003067","article-title":"The role of bacterial biofilm in adverse soft-tissue filler reactions: a combined laboratory and clinical study","volume":"139","author":"M Saththianathan","year":"2017","journal-title":"Plast Reconstr Surg"},{"issue":"08","key":"ref56","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1001\/jamadermatol.2017.0995","article-title":"Association of different surgical sterile prep solutions with infection risk after cutaneous surgery of the head and neck","volume":"153","author":"M Alam","year":"2017","journal-title":"JAMA Dermatol"},{"issue":"02","key":"ref57","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1055\/s-0029-1220653","article-title":"The management of dermal filler complications","volume":"25","author":"C P Winslow","year":"2009","journal-title":"Facial Plast Surg"},{"key":"ref58","first-page":"39","article-title":"Soft-tissue fillers","volume":"2","author":"T M Born","year":"2013","journal-title":"Plast Surg (Oakv)"},{"issue":"02","key":"ref59","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1055\/s-0029-1220646","article-title":"The biology of facial fillers","volume":"25","author":"S H Bentkover","year":"2009","journal-title":"Facial Plast Surg"},{"issue":"04","key":"ref60","doi-asserted-by":"crossref","first-page":"e10051","DOI":"10.1371\/journal.pone.0010051","article-title":"Macrophages recognize size and shape of their targets","volume":"5","author":"N Doshi","year":"2010","journal-title":"PLoS ONE"},{"issue":"01","key":"ref61","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/DSS.0000000000000562","article-title":"Resistant and recurrent late reaction to hyaluronic acid-based gel","volume":"42","author":"O Artzi","year":"2016","journal-title":"Dermatol Surg"},{"issue":"07","key":"ref62","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1136\/jcp.36.7.723","article-title":"Granulomatous inflammation\u2013a review","volume":"36","author":"G T Williams","year":"1983","journal-title":"J Clin Pathol"},{"issue":"06","key":"ref63","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1097\/PRS.0b013e3181858f4f","article-title":"Foreign body granulomas after all injectable dermal fillers: part 2. Treatment options","volume":"123","author":"G Lemperle","year":"2009","journal-title":"Plast Reconstr Surg"},{"issue":"06","key":"ref64","doi-asserted-by":"crossref","first-page":"961e","DOI":"10.1097\/PRS.0000000000002184","article-title":"Global Aesthetics Consensus: avoidance and management of complications from hyaluronic acid fillers-evidence- and opinion-based review and consensus recommendations","volume":"137","author":"M Signorini","year":"2016","journal-title":"Plast Reconstr Surg"},{"issue":"03","key":"ref65","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/srt.12445","article-title":"An innovative method to quantitate tissue integration of hyaluronic acid-based dermal fillers","volume":"24","author":"A S Dugaret","year":"2018","journal-title":"Skin Res Technol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2147\/CCID.S315076","article-title":"Comparative analyses of inflammatory response and tissue integration of 14 hyaluronic acid-based fillers in mini pigs","volume":"14","author":"M S Choi","year":"2021","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"05","key":"ref67","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1524-4725.2010.01852.x","article-title":"Comparative histology of intradermal implantation of mono and biphasic hyaluronic acid fillers","volume":"37","author":"T C Flynn","year":"2011","journal-title":"Dermatol Surg"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1524-4725.2012.02471.x","article-title":"Superficial dermal injection of hyaluronic acid soft tissue fillers: comparative ultrasound study","volume":"38","author":"P Micheels","year":"2012","journal-title":"Dermatol Surg"},{"issue":"06","key":"ref69","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/IOP.0000000000001374","article-title":"Hyaluronic acid gel biodegradation after intrapalpebral and intraorbital injection in experimental study","volume":"35","author":"V Sheptulin","year":"2019","journal-title":"Ophthal Plast Reconstr Surg"}],"container-title":["Archives of Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2184-6554.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:40:12Z","timestamp":1730806812000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2184-6554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":67,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,2,28]]},"published-print":{"date-parts":[[2024,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2184-6554","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2234-6163","2234-6171"],"issn-type":[{"value":"2234-6163","type":"print"},{"value":"2234-6171","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9,29]]},"published":{"date-parts":[[2023,9,29]]}}}