{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:26:55Z","timestamp":1788910015853,"version":"build-2803163510"},"reference-count":77,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b2-Thalassemia major is a congenital hemoglobin disorder that requires\n                    regular blood transfusion. The disease is often associated with iron overload\n                    and diabetes mellitus, among other complications. Pancreatic iron overload in\n                    \u03b2-thalassemia patients disrupts \u03b2-cell function and insulin\n                    secretion and induces insulin resistance. Several risk factors, including family\n                    history of diabetes, sedentary lifestyle, obesity, gender, and advanced age\n                    increase the risk of diabetes in \u03b2-thalassemia patients. Precautionary\n                    measures such as blood glucose monitoring, anti-diabetic medications, and\n                    healthy living in \u03b2-thalassemia patients notwithstanding, the prevalence\n                    of diabetes in \u03b2-thalassemia patients continues to rise. This review\n                    aims to address the relationship between \u03b2-thalassemia and diabetes in\n                    an attempt to understand how the pathology and management of\n                    \u03b2-thalassemia precipitate diabetes mellitus. The possible employment of\n                    surrogate biomarkers for early prediction and intervention is discussed. More\n                    work is still needed to better understand the molecular mechanism(s) underlying\n                    the link between \u03b2-thalassemia and diabetes and to identify novel\n                    prognostic and therapeutic targets.<\/jats:p>","DOI":"10.1055\/a-2185-5073","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T23:01:22Z","timestamp":1698102082000},"page":"272-278","source":"Crossref","is-referenced-by-count":8,"title":["\u03b2-Thalassemia and Diabetes Mellitus: Current State and Future\n                    Directions"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3341-1063","authenticated-orcid":false,"given":"Jalal","family":"Taneera","sequence":"additional","affiliation":[{"name":"Sharjah Institute for Medical Research, University of Sharjah, Sharjah,\n                    United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eglal","family":"Mahgoub","sequence":"additional","affiliation":[{"name":"Sharjah Institute for Medical Research, University of Sharjah, Sharjah,\n                    United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Qannita","sequence":"additional","affiliation":[{"name":"Sharjah Institute for Medical Research, University of Sharjah, Sharjah,\n                    United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayah","family":"Alalami","sequence":"additional","affiliation":[{"name":"Sharjah Institute for Medical Research, University of Sharjah, Sharjah,\n                    United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola Al","family":"Shehadat","sequence":"additional","affiliation":[{"name":"Sharjah Institute for Medical Research, University of Sharjah, Sharjah,\n                    United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Youssef","sequence":"additional","affiliation":[{"name":"Sharjah Institute for Medical Research, University of Sharjah, Sharjah,\n                    United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayah","family":"Dib","sequence":"additional","affiliation":[{"name":"Sharjah Institute for Medical Research, University of Sharjah, Sharjah,\n                    United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa Al","family":"Hajji","sequence":"additional","affiliation":[{"name":"Sharjah Institute for Medical Research, University of Sharjah, Sharjah,\n                    United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani Al","family":"Hajji","sequence":"additional","affiliation":[{"name":"Sharjah Institute for Medical Research, University of Sharjah, Sharjah,\n                    United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatheya","family":"Al-Khaja","sequence":"additional","affiliation":[{"name":"Dubai Thalassemia Center, Dubai, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Dewedar","sequence":"additional","affiliation":[{"name":"Dubai Thalassemia Center, Dubai, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mawieh","family":"Hamad","sequence":"additional","affiliation":[{"name":"University of Sharjah College of Health Sciences, Sharjah, United Arab\n                    Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1172-5-11","article-title":"Beta-thalassemia","volume":"5","author":"R Galanello","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/S0140-6736(22)00536-0","article-title":"Thalassaemia","volume":"399","author":"A Kattamis","year":"2022","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"s28","DOI":"10.1179\/102453312X13336169155295","article-title":"Thalassemia","volume":"17","author":"Y Aydinok","year":"2012","journal-title":"Hematology"},{"key":"ref4","volume-title":"Thalassemia. 2019; 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