{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:42Z","timestamp":1740126822456,"version":"3.37.3"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aim We aimed to describe the clinical characteristics of patients with\n                    congenital combined pituitary hormone deficiency (CPHD) and evaluate the\n                    first-year growth responses of individuals with CPHD and isolated growth hormone\n                    deficiency (IGHD) in order to establish the influence of other hormone\n                    deficiencies on growth response.<\/jats:p><jats:p>\n          Patients and Methods This retrospective study was conducted in four\n                    tertiary care centers in Turkey. The records of patients diagnosed with CPHD\n                    (n=39) and severe IGHD (n=50) were collected. Cases with\n                    acquired lesions or chronic diseases were not included in the study. Data are\n                    presented as median (interquartile range).<\/jats:p><jats:p>\n          Results Among 39 patients (13 females; 33%) with a diagnosis of\n                    CPHD, the majority of patients (64%) presented initially with combined\n                    deficits at baseline examination, whereas isolated deficiencies (36%)\n                    were less prevalent. Among all patients with GH deficiency, TSH, ACTH,\n                    FSH\/LH, and ADH deficiencies were present in 94%, 74%,\n                    44%, and 9% of patients, respectively. Patients with CPHD were\n                    diagnosed at a younger age (4.9 (8.4) vs. 11.6 (4.1), p&lt;0.001,\n                    respectively) and had lower peak GH concentrations (0.4 (1.8) vs. 3.7 (2.9),\n                    p&lt;0.001, respectively) than patients with IGHD. Patients with IGHD and\n                    CPHD had similar first-year growth responses (\u0394height SD score of 0.55\n                    (0.63) vs. 0.76 (0.71), respectively, p=0.45).<\/jats:p><jats:p>\n          Conclusions We established the nature and timing of numerous hormonal\n                    deficits emerging over time. We also identified that the existence of CPHD did\n                    not hinder growth response.<\/jats:p>","DOI":"10.1055\/a-2186-9304","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:24:05Z","timestamp":1701735845000},"page":"11-20","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics of Children with Combined Pituitary Hormone\n                    Deficiency and the Effects of Growth Hormone Treatment"],"prefix":"10.1055","volume":"237","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3135-9617","authenticated-orcid":false,"given":"\u00d6zge","family":"Besci","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Dokuz Eylul University, \u0130zmir,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyhan Deveci","family":"Sevim","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Adnan Menderes University, Aydin,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00fcbra Y\u00fcksek","family":"Acinikli","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Dokuz Eylul University, \u0130zmir,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korcan","family":"Demir","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Dokuz Eylul University, \u0130zmir,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6n\u00fcl","family":"\u00c7atl\u0131","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Istinye University, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bayram","family":"\u00d6zhan","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Pamukkale University, Denizli,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolga","family":"\u00dcn\u00fcvar","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Adnan Menderes University, Aydin,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"An\u0131k","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Adnan Menderes University, Aydin,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayhan","family":"Abac\u0131","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Dokuz Eylul University, \u0130zmir,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u00e7a","family":"Alt\u0131nc\u0131k","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Pamukkale University, Denizli,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1210\/er.2016-1101","article-title":"Genetics of combined pituitary hormone deficiency: Roadmap into the genome\n                    era","volume":"37","author":"Q Fang","year":"2016","journal-title":"Endocr Rev"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"101556","DOI":"10.1016\/j.eclinm.2022.101556","article-title":"Presentation and diagnosis of childhood-onset combined pituitary hormone\n                    deficiency: A single center experience from over 30 years","volume":"51","author":"J Hietamaki","year":"2022","journal-title":"EClinicalMedicine"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad198","article-title":"Diagnosis and incidence of congenital combined pituitary hormone deficiency in\n                    denmark - a national observational study","author":"L K Jakobsen","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40618-014-0141-2","article-title":"Combined pituitary hormone deficiency: Current and future status","volume":"38","author":"F Castinetti","year":"2015","journal-title":"J Endocrinol Invest"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1159\/000329161","article-title":"Response to growth hormone treatment in isolated growth hormone deficiency\n                    versus multiple pituitary hormone deficiency","volume":"76","author":"F Darendeliler","year":"2011","journal-title":"Horm Res Paediatr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e90","DOI":"10.3346\/jkms.2022.37.e90","article-title":"Growth responses during 3 years of growth hormone treatment in children and\n                    adolescents with growth hormone deficiency: Comparison between idiopathic,\n                    organic and isolated growth hormone deficiency, and multiple pituitary hormone\n                    deficiency","volume":"37","author":"H H Lim","year":"2022","journal-title":"J Korean Med Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1210\/jc.2006-0050","article-title":"Adult height in patients with permanent growth hormone deficiency with and\n                    without multiple pituitary hormone deficiencies","volume":"91","author":"M Maghnie","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"720419","DOI":"10.3389\/fendo.2021.720419","article-title":"Short and long-term effects of growth hormone in children and adolescents with\n                    gh deficiency","volume":"12","author":"M B Ranke","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1007\/s12020-019-02057-x","article-title":"Growth hormone therapy in children: Predictive factors and short-term and\n                    long-term response criteria","volume":"66","author":"G Pozzobon","year":"2019","journal-title":"Endocrine"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"125","DOI":"10.4274\/jcrpe.galenos.2019.2019.0127","article-title":"New features for child metrics: Further growth references and blood pressure\n                    calculations","volume":"12","author":"K Demir","year":"2020","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1159\/000322878","article-title":"A comparison of different definitions of growth response in short prepubertal\n                    children treated with growth hormone","volume":"75","author":"P Bang","year":"2011","journal-title":"Horm Res Paediatr"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1210\/jc.2009-1471","article-title":"Observed and predicted growth responses in prepubertal children with growth\n                    disorders: Guidance of growth hormone treatment by empirical variables","volume":"95","author":"M B Ranke","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1515\/jpem-2020-0029","article-title":"A nonsense variant in fgfr1: A rare cause of combined pituitary hormone\n                    deficiency","volume":"33","author":"I M Erbas","year":"2020","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1186\/s12887-019-1819-6","article-title":"Distinct pituitary hormone levels of 184 chinese children and adolescents with\n                    multiple pituitary hormone deficiency: A single-centre 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Paediatr"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1210\/er.2018-00017","article-title":"Pathophysiology and individualized treatment of hypothalamic obesity following\n                    craniopharyngioma and other suprasellar tumors: A systematic review","volume":"40","author":"L van Iersel","year":"2019","journal-title":"Endocr Rev"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ghir.2017.10.005","article-title":"Progression from isolated growth hormone deficiency to combined pituitary\n                    hormone deficiency","volume":"37","author":"M Cerbone","year":"2017","journal-title":"Growth Horm IGF Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1210\/clinem\/dgac129","article-title":"Approach to the patient: Management of pituitary hormone replacement through\n                    transition","volume":"107","author":"M Cerbone","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s40348-020-00108-2","article-title":"Evolving pituitary hormone deficits in primarily isolated ghd: A review and\n                    experts\u2019 consensus","volume":"7","author":"G Binder","year":"2020","journal-title":"Mol Cell Pediatr"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1530\/EJE-13-0643","article-title":"Development of additional pituitary hormone deficiencies in pediatric patients\n                    originally diagnosed with idiopathic isolated gh deficiency","volume":"170","author":"W F Blum","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s11102-014-0610-9","article-title":"Frequent development of combined pituitary hormone deficiency in patients\n                    initially diagnosed as isolated growth hormone deficiency: A long term follow-up\n                    of patients from a single center","volume":"18","author":"A P Otto","year":"2015","journal-title":"Pituitary"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1159\/000486033","article-title":"Low ft4 concentrations around the start of recombinant human growth hormone\n                    treatment: Predictor of congenital structural hypothalamic-pituitary\n                    abnormalities?","volume":"89","author":"L van Iersel","year":"2018","journal-title":"Horm Res Paediatr"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1365-2265.2006.02688.x","article-title":"Unmasking of central hypothyroidism following growth hormone replacement in\n                    adult hypopituitary patients","volume":"66","author":"A Agha","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/bf00441309","article-title":"Final height and pubertal development in 55 children with idiopathic growth\n                    hormone deficiency, treated for between 2 and 15 years with human growth\n                    hormone","volume":"137","author":"E C Burns","year":"1981","journal-title":"Eur J Pediatr"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1159\/000448098","article-title":"Long-term outcomes, genetics, and pituitary morphology in patients with isolated\n                    growth hormone deficiency and multiple pituitary hormone deficiencies: A\n                    single-centre experience of four decades of growth hormone replacement","volume":"86","author":"J Rohayem","year":"2016","journal-title":"Horm Res Paediatr"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"167","DOI":"10.20945\/2359-3997000000139","article-title":"Combined pituitary hormone deficiency caused by prop1 mutations: Update 20 years\n                    post-discovery","volume":"63","author":"F A Correa","year":"2019","journal-title":"Arch Endocrinol Metab"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"4353","DOI":"10.1210\/jcem.86.9.7828","article-title":"Longitudinal imaging reveals pituitary enlargement preceding hypoplasia in two\n                    brothers with combined pituitary hormone deficiency attributable to prop1\n                    mutation","volume":"86","author":"F G Riepe","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/s41598-018-38178-y","article-title":"High frequency of chd7 mutations in congenital hypogonadotropic\n                    hypogonadism","volume":"9","author":"C I Goncalves","year":"2019","journal-title":"Sci Rep"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2186-9304.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T23:44:38Z","timestamp":1736552678000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2186-9304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,4]]},"references-count":30,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2025,1,10]]},"published-print":{"date-parts":[[2025,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2186-9304","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"type":"print","value":"0300-8630"},{"type":"electronic","value":"1439-3824"}],"subject":[],"published":{"date-parts":[[2023,12,4]]}}}