{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:31:42Z","timestamp":1763724702430,"version":"3.37.3"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"National Research Foundation of Korea (NRF), the Ministry of Science, ICT & Future Planning","award":["2020R1A2C10042721440982119420104"],"award-info":[{"award-number":["2020R1A2C10042721440982119420104"]}]},{"name":"Jeju Institute of Korean Medicine","award":["ERT2011180"],"award-info":[{"award-number":["ERT2011180"]}]},{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"crossref","award":["KSN1822320"],"award-info":[{"award-number":["KSN1822320"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Agastache rugosa Kuntze (Lamiaceae; Labiatae), a medicinal and functional herb used to treat gastrointestinal diseases, grows well both on islands and inland areas in South Korea.\n          Thus, we aimed to reveal the morphological and micromorphological differences between A.\u00a0rugosa grown on island and inland areas and their pharmacological effects on gastritis in an\n          animal model by combining morphological and mass spectrophotometric analyses. Morphological analysis showed that island A.\u00a0rugosa had slightly smaller plants and leaves than inland\n          plants; however, the density of all types of trichomes on the leaves, petioles, and stems of island A.\u00a0rugosa was significantly higher than that of inland plants. The essential oil\n          component analysis revealed that pulegone levels were substantially higher in island A.\u00a0rugosa than in inland A.\u00a0rugosa. Despite the differences between island and inland\n          A.\u00a0rugosa, treatment with both island and inland A.\u00a0rugosa reduced gastric damages by more than 40% compared to the gastritis induction group. In addition, expression of\n          inflammatory protein was reduced by about 30% by treatment of island and inland A.\u00a0rugosa. The present study demonstrates quantitative differences in morphology and volatile\n          components between island and inland plants; significant differences were not observed between the gastritis-inhibitory effects of island and inland A.\u00a0rugosa, and the efficacy of\n          island A.\u00a0rugosa was found to be similar to that of A.\u00a0rugosa grown in inland areas.<\/jats:p>","DOI":"10.1055\/a-2189-7272","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:42:01Z","timestamp":1698712921000},"page":"4-12","source":"Crossref","is-referenced-by-count":5,"title":["Comparative Morphology of Island and Inland Agastache rugosa and Their Gastroprotective Effects in EtOH\/HCl-Induced Gastric Mucosal Gastritis"],"prefix":"10.1055","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-4710","authenticated-orcid":false,"given":"Jun-Ho","family":"Song","sequence":"first","affiliation":[{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si, Jeollanam-do, Korea"},{"name":"Department of Biology, Chungbuk National University, Cheongju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon-Hwa","family":"Nam","sequence":"first","affiliation":[{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si, Jeollanam-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inkyu","family":"Park","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si, Jeollanam-do, Korea"},{"name":"Department of Biology and Chemistry, Changwon National University, Changwon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si, Jeollanam-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Mi","family":"Chun","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si, Jeollanam-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Soo","family":"Seo","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si, Jeollanam-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si, Jeollanam-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong Cheol","family":"Moon","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si, Jeollanam-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjong","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-IL","family":"Kang","sequence":"additional","affiliation":[{"name":"Jeju Institute of Korean Medicine, Jeju-si, Jeju-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hoon","family":"Song","sequence":"additional","affiliation":[{"name":"Jeju Institute of Korean Medicine, Jeju-si, Jeju-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joong-Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"volume-title":"The Korean Herbal Pharmacopoeia. 4th ed","year":"2020","author":"Korea Food and Drug Administration","key":"ref1"},{"key":"ref2","first-page":"93","volume-title":"Agastache","author":"C W Park","year":"2018"},{"key":"ref3","first-page":"824605","article-title":"Effect of Korean herbal medicine combined with a probiotic mixture on diarrhea-dominant irritable bowel syndrome: A double-blind, randomized, placebo-controlled trial","volume":"2013","author":"S J Ko","year":"2013","journal-title":"Evid Based Complement Alternat 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