{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:17:36Z","timestamp":1778548656070,"version":"3.51.4"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cannabis as a therapeutic agent is increasing in popularity all around the globe, particularly in Western countries, and its potential is now well assessed. On the other hand, each country\n          has its own regulation for the preparation of cannabis macerated oils; in Italy, there are only a few preparation methods allowed. With this work, we aim to perform a stability study of\n          cannabis oils produced with a novel method for the extraction of cannabinoids from cannabis inflorescence. Three different varieties of cannabis were used, with and without the adding of\n          tocopherol acetate as an antioxidant. Cannabinoids were extracted using ethanol at room temperature; then, the solvent was evaporated under reduced pressure and the preparations\n          reconstituted with olive oil. In this work, we assessed the stability of both cannabinoids and terpenes in these formulas over 8 months. Cannabinoid stability was assessed by monitoring the\n          concentrations of THC and CBD, while terpene stability was assessed by monitoring \u03b2-Caryophyllene and \u03b1-Humulene concentrations. Stability of the extracts was not influenced by\n          the presence of tocopherol acetate, though refrigeration seems to be detrimental for a long storage of products, especially regarding THC concentrations. The improvements offered by this\n          method reside in the flexibility in controlling the concentration of the extract and the ability to produce highly concentrated oils, alongside the possibility to produce standardized oils\n          despite the variability of the starting plant material.<\/jats:p>","DOI":"10.1055\/a-2189-8155","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:17:31Z","timestamp":1700007451000},"page":"73-80","source":"Crossref","is-referenced-by-count":3,"title":["Medicinal Cannabis: Extended Stability of Cannabis Extracts Produced Using a New Ethanol-based Extraction Method"],"prefix":"10.1055","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0352-2819","authenticated-orcid":false,"given":"Camillo","family":"Morano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Dei Cas","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Casagni","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Pallavicini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Bolchi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Penati","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Cuomo","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori IRCCS, Fondazione \u2018G. Pascale\u2019, Division of Anesthesia and Pain Medicine, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Cascella","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori IRCCS, Fondazione \u2018G. Pascale\u2019, Division of Anesthesia and Pain Medicine, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Bimonte","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori IRCCS, Fondazione \u2018G. Pascale\u2019, Division of Anesthesia and Pain Medicine, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Spensiero","sequence":"additional","affiliation":[{"name":"Compounding Laboratory, Farmacia Caputo, Nocera Superiore (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ferrari","sequence":"additional","affiliation":[{"name":"THC Lab srl, Mirandola (MO), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annunziata","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Compounding Laboratory, Farmacia Caputo, Nocera Superiore (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Roda","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"412","DOI":"10.5740\/JAOACINT.18-0208","article-title":"A brief background on cannabis: From plant to medical indications","volume":"102","author":"L E Klumpers","year":"2019","journal-title":"J AOAC Int"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/PHAR.1187","article-title":"The pharmacologic and clinical effects of medical cannabis","volume":"33","author":"L M Borgelt","year":"2013","journal-title":"Pharmacotherapy"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1111\/HEAD.13345","article-title":"Medicinal properties of cannabinoids, terpenes, and flavonoids in cannabis, and benefits in migraine, headache, and pain: An update on current evidence and cannabis science","volume":"58","author":"E P 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preparations","volume":"84","author":"A Casiraghi","year":"2018","journal-title":"Planta Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jpba.2017.11.073","article-title":"Comprehensive quality evaluation of medical Cannabis sativa L. inflorescence and macerated oils based on HS-SPME coupled to GC\u2013MS and LC-HRMS (q-Exactive Orbitrap) approach","volume":"150","author":"L Calvi","year":"2018","journal-title":"J Pharm Biomed Anal"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1515\/CCLM-2016-1060","article-title":"Evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass\n          spectrometry","volume":"55","author":"R Pacifici","year":"2017","journal-title":"Clin Chem Lab Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/9780470027318.a8102","article-title":"Karl Fischer moisture determination","volume":"1","author":"K Sch\u00f6ffski","year":"2000","journal-title":"Encycl Anal Chem"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"110113","DOI":"10.1016\/j.forsciint.2019.110113","article-title":"The Italian panorama of cannabis light preparation: Determination of cannabinoids by LC-UV","volume":"307","author":"M Dei Cas","year":"2020","journal-title":"Forensic Sci Int"}],"container-title":["Planta 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