{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:11:02Z","timestamp":1790392262263,"version":"4.1.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Else Kr\u00f6ner-Fresenius Stiftung and the Eva Luise K\u00f6hler Stiftung within thev RISE Clinician Scientist"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with adrenal insufficiency (AI) have been found to have increased\n                    cardiovascular morbidity, partly associated with nonphysiologic glucocorticoid\n                    replacement. We included two separate cohorts (cohort 1 n=384 patients,\n                    cohort 2 n=180 patients) of patients with chronic primary and secondary\n                    AI under standard replacement therapy and compared them to two age- and\n                    sex-matched population-based studies (SHIP-TREND\/DEGS). Odds ratios with\n                    95% CI for hypertension, hyperlipidemia\/HLP, type 2\n                    diabetes\/T2DM, obesity, and hospitalization with adjustment for\n                    confounders were evaluated by logistic regression. Patient cohort 1 had\n                    significantly lower ORs for obesity [0.4 (0.3\u20130.6), p&lt;0.001] and\n                    hypertension [0.5 (0.3\u20130.6), p&lt;0.001] compared to SHIP-TREND and\n                    for obesity [0.7 (0.5\u20130.9), p=0.01], hypertension [0.4\n                    (0.3\u20130.5), p&lt;0.001] and HLP [0.4 (0.3\u20130.6),\n                    p&lt;0.001] compared to DEGS. In cohort 2, ORs were significantly lower for\n                    HLP compared to both SHIP-TREND [0.4 (0.2\u20130.7), p=0.001] and\n                    DEGS [0.3 (0.2\u20130.5), p&lt;0.001] and for hypertension [0.7\n                    (0.4\u20130.9), p=0.04] compared to SHIP-TREND. In patients with SAI\n                    from cohort 2, ORs for DM2 [2.5 (1.3\u20134.9) p=0.009], hypertension\n                    [2.5 (1.4\u20134.5), p=0.002] and obesity [1.9 (1.1\u20133.1),\n                    p=0.02] were significantly higher compared to DEGS, whereas ORs for HLP\n                    were significantly lower compared to both SHIP [0.3 (0.1\u20130.6),\n                    p=0.002] and DEGS [0.3 (0.1\u20130.6), p&lt;0.001]. In most of\n                    our AI patients treated with conventional glucocorticoid doses, the risk for\n                    T2DM, obesity, hypertension, and HLP was not increased. The number of\n                    hospitalizations was significantly higher in AI patients compared to controls,\n                    which might reflect increased susceptibility but also a more proactive\n                    management of concomitant diseases by physicians and patients.<\/jats:p>","DOI":"10.1055\/a-2190-3735","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T23:39:08Z","timestamp":1697153948000},"page":"20-29","source":"Crossref","is-referenced-by-count":7,"title":["Morbidity in Patients with Chronic Adrenal Insufficiency \u2013\n                    Cardiovascular Risk Factors and Hospitalization Rate Compared to Population\n                    Based Controls"],"prefix":"10.1055","volume":"56","author":[{"given":"Stephanie","family":"Burger-Stritt","sequence":"first","affiliation":[{"name":"Endocrinology and Diabetes Unit, Department of Medicine I, University\n                    of Wuerzburg, Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Hahner","sequence":"first","affiliation":[{"name":"Endocrinology and Diabetes Unit, Department of Medicine I, University\n                    of Wuerzburg, Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Chifu","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetes Unit, Department of Medicine I, University\n                    of Wuerzburg, Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-1671","authenticated-orcid":false,"given":"Marcus","family":"Quinkler","sequence":"additional","affiliation":[{"name":"Endocrinology in Charlottenburg\/Berlin, Berlin,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Altieri","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetes Unit, Department of Medicine I, University\n                    of Wuerzburg, Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Hannemann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University\n                    Medicine Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine, University Medicine Greifswald,\n                    Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Lang","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetes Unit, Department of Medicine I, University\n                    of Wuerzburg, Wuerzburg, Germany"},{"name":"Endocrinology in Charlottenburg\/Berlin, Berlin,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Reisch","sequence":"additional","affiliation":[{"name":"Department of Endocrine Research, Department of Medicine IV,\n                    Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Pamporaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Carl Gustav\n                    Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5362-7075","authenticated-orcid":false,"given":"Holger Sven","family":"Willenberg","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Rostock University Medical\n                    Center, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7826-3984","authenticated-orcid":false,"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"Department of Endocrine Research, Department of Medicine IV,\n                    Ludwig-Maximilians-University, Munich, Germany"},{"name":"Department of Endocrinology, Diabetology and Clinical Nutrition,\n                    University Hospital Zurich (USZ), and University of Zurich (UZH), Zurich,\n                    Switzerland"},{"name":"LOOP Zurich \u2013 Medical Research Center, Zurich,\n                    Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1210\/jc.2006-0076","article-title":"Premature mortality in patients with Addison\u2019s disease: a\n                    population-based 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