{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:21:09Z","timestamp":1784892069778,"version":"3.55.0"},"reference-count":68,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The human microbiome plays an integral role in health. In particular, it is\n                    important for the development, differentiation, and maturation of the immune\n                    system, 70% of which resides in the intestinal mucosa. Microbiome\n                    studies conducted to date have revealed an association between disturbances in\n                    the microbiota (dysbiosis) and various pathological disorders, including changes\n                    in host immune status. Autoimmune thyroid diseases are one of the most common\n                    organ-specific autoimmune disorders, with a worldwide prevalence higher than\n                    5%. The predominant autoimmune thyroid diseases are Hashimoto\u2019s\n                    thyroiditis and Grave\u2019s disease. Several factors, such as genetic and\n                    environmental ones, have been studied. In accordance with recent studies, it is\n                    assumed that the gut microbiome might play a significant role in triggering\n                    autoimmune diseases of the thyroid gland. However, the exact etiology has not\n                    yet been elucidated. The present review aims to describe the work carried out so\n                    far regarding the role of gut microflora in the pathogenesis of autoimmune\n                    thyroid diseases and its involvement in the appearance of benign nodules and\n                    papillary thyroid cancer. It appears that future work is needed to elucidate\n                    more precisely the mechanism for gut microbiota involvement in the development\n                    of autoimmune thyroid diseases.<\/jats:p>","DOI":"10.1055\/a-2190-3847","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T22:47:34Z","timestamp":1697064454000},"page":"813-818","source":"Crossref","is-referenced-by-count":14,"title":["Thyroid Diseases and Intestinal Microbiome"],"prefix":"10.1055","volume":"55","author":[{"given":"Ioannis","family":"Legakis","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, European University Cyprus, Nicosia,\n                    Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George P.","family":"Chrousos","sequence":"additional","affiliation":[{"name":"First Department of Pediatrics, University of Athens Medical School,\n                    Aghia Sophia Children's Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Chatzipanagiotou","sequence":"additional","affiliation":[{"name":"Microbiology, National and Kapodistrian University of Athens, Athens,\n                    Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cell.2006.02.017","article-title":"Ecological and evolutionary forces shaping microbial diversity in the human\n                    intestine","volume":"124","author":"R E Ley","year":"2006","journal-title":"Cell"},{"key":"ref2","first-page":"711","volume-title":"Microbes and Man. 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