{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:26:41Z","timestamp":1730870801863,"version":"3.28.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n            Epidemiologie, Risikofaktoren und Ausl\u00f6ser Neue epidemiologische Daten gehen von einer deutlich h\u00f6heren j\u00e4hrlichen Inzidenz aus als sie bisher vermutet wurde, n\u00e4mlich von ca. 15 F\u00e4llen pro 100000 Personen. Bei mind. 10% der Betroffenen kommt es zu 1\u20133 Rezidiven.<\/jats:p><jats:p>\n            Anatomie der Funktionsst\u00f6rungen Die punkf\u00f6rmigen L\u00e4sionen im Hippocampus, die sich bei mind. 50% der Betroffenen im MRT finden, sind zu \u2154 unilateral und zu \u2153 bilateral verteilt. Durch eine MRT-Bildgebung mit 7 Tesla lassen sich mit fast 90% mehr L\u00e4sionen entdecken als mit 1,5 oder 3 Tesla-Ger\u00e4ten (ca. 50%). Jenseits der punktf\u00f6rmigen Hippocampus-L\u00e4sionen sind auch dar\u00fcberhinausgehende ged\u00e4chtnisrelevante Netzwerkst\u00f6rungen, einschlie\u00dflich des Ruhezustands-Netzwerks (Default Network) f\u00fcr die Symptome der TGA verantwortlich.<\/jats:p><jats:p>\n            Hypothesen zur Verursachung Die fr\u00fcher diskutierte arteriell-isch\u00e4mische Genese der St\u00f6rungen im Hippocampus ist sehr unwahrscheinlich. Unterschiedliche Pathomechanismen wie eine ven\u00f6se Kongestion und migr\u00e4neartige Depolarisationen spielten wahrscheinlich eine Rolle in der Genese.<\/jats:p><jats:p>\n            Diagnose und Management \u00dcber die Diagnose der typischen klinischen Pr\u00e4sentation hinaus gelten weitere Auff\u00e4lligkeiten wie bspw. quantitative Bewusstseinsst\u00f6rungen, starke Kopfschmerzen oder Erbrechen als \u201eRed Flags\u201c und erfordern eine umfassende neurologische Abkl\u00e4rung, um eine andere neurologische Verursachung auszuschlie\u00dfen.<\/jats:p>","DOI":"10.1055\/a-2190-5900","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T22:43:13Z","timestamp":1716504193000},"page":"728-733","source":"Crossref","is-referenced-by-count":0,"title":["Transiente globale Amnesie \u2013 gutartiger \u201eBlackout\u201c im Ged\u00e4chtnis"],"prefix":"10.1055","volume":"149","author":[{"given":"Frank 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