{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:01Z","timestamp":1740126841185,"version":"3.37.3"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Purpose To assess ultrasound (US) features observed in salivary glands after radioactive iodine treatment (RAIT) in relation to the dose and time interval after RAIT.<\/jats:p><jats:p>\n            Materials and Methods A retrospective analysis of US findings regarding the salivary glands of patients presenting after RAIT due to thyroid cancer (Group 1, n=99) or benign thyroid diseases (Group 2, n=25). The control group consisted of randomly selected patients (no RAIT, Group 3, n=100). Groups were compared regarding RAIT dose, symptoms, and US findings (duct dilation, hypoechoic\/heterogeneous parenchyma, parenchymal loss). The association of the presence of US parameters after RAIT with various dose levels (2000\u201315000MBq) and time intervals (24, 60, 120 months) and the differences between the groups was evaluated.<\/jats:p><jats:p>\n            Results Significant differences between US parameters were noted when comparing Group 1 with Group 2 or 3. Nothing of relevant significance was noted when Groups 2 and 3 were compared. US features indicating a slight or moderate sialadenitis showed the most significant associations with doses &lt;4000MBq and time intervals &lt;24 months after RAIT. US changes indicating a serious sialadenitis or even gland atrophy showed the most significant association at doses between &gt;7000\u20139000MBq and when US was performed &gt;60 months after RAIT.<\/jats:p><jats:p>\n            Conclusion Our results point to a dose and time dependency of pathologic US findings in RAIT-induced effects on the major salivary glands. Based on the US findings, a better estimation of the current impact of RAIT on the salivary glands and the further prognosis appears possible.<\/jats:p>","DOI":"10.1055\/a-2190-6751","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T23:57:32Z","timestamp":1704326252000},"page":"629-641","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasound Changes in Salivary Glands after Radioactive Iodine Treatment in Benign Diseases and Differentiated Cancer of Thyroid Glands in Consideration of Dose and Time Dependency"],"prefix":"10.1055","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7838-6490","authenticated-orcid":false,"given":"Michael","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head & Neck Surgery, Erlangen University Hospital, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Fauck","sequence":"additional","affiliation":[{"name":"ENT, Head and Neck Surgery, Nuremberg Hospital Campus North, Nurnberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Sievert","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head & Neck Surgery, Erlangen University Hospital, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Mantsopoulos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head & Neck Surgery, Erlangen University Hospital, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Iro","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head & Neck Surgery, Erlangen University Hospital, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarina","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head & Neck Surgery, Erlangen University Hospital, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3413\/Nukmed-0875-17-01","article-title":"Radioiodine therapy of benign thyroid-disorders","volume":"56","author":"T Hartmann","year":"2017","journal-title":"Nuklearmedizin"},{"issue":"09","key":"ref2","first-page":"1551","article-title":"Intermediate and long-term side effects of high-dose radioiodine therapy for thyroid carcinoma","volume":"39","author":"C Alexander","year":"1998","journal-title":"J Nucl 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