{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:06:08Z","timestamp":1768485968156,"version":"3.49.0"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n            Anorektale Funktionsdiagnostik Eine fr\u00fchzeitige anorektale Funktionsdiagnostik zur Stratifizierung der weiteren Therapiewege ist kosteneffizient.<\/jats:p><jats:p>\n            Therapie mit Laxanzien Klassische Laxanzien wie Macrogol, Bisacodyl und Natriumpicosulfat k\u00f6nnen nach aktueller Studienlage unbedenklich auch langfristig eingesetzt werden. Moderne Obstipations-Medikamente wie z.B. Linaclotid und Plecanatid sind oft hochwirksame Reservemedikament f\u00fcr die anderweitig nicht therapierbare Obstipation, insbesondere auch bei begleitenden Reizdarmsymptomen. Die H\u00fcrden der Verschreibung limitieren den Einsatz.<\/jats:p><jats:p>\n            Neue Therapieentwicklungen Eine m\u00f6gliche neue Therapieoption k\u00f6nnte eine vibrierende Kapsel sein, die oral eingenommen wird und die auf ihrem Weg durch den Gastrointestinaltrakt die Darmmotorik von innen stimulieren soll. Die Kapsel ist derzeit nur in den USA zugelassen. Die aktualisierte Leitlinie Chronische Obstipation empfiehlt weiter eine therapeutische Stufenstrategie. Therapiema\u00dfnahmen sollten bedarfsadaptiert eingesetzt werden. Um Fehltherapien zu vermeiden, ist die Detektion der Ursachen einer Stuhlentleerungsst\u00f6rung von gro\u00dfer Bedeutung.<\/jats:p>","DOI":"10.1055\/a-2194-3285","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T22:53:29Z","timestamp":1729637609000},"page":"1324-1328","source":"Crossref","is-referenced-by-count":1,"title":["Chronische Obstipation"],"prefix":"10.1055","volume":"149","author":[{"given":"Viola","family":"Andresen","sequence":"additional","affiliation":[{"name":"Medizinicum, Hamburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Layer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik, Israelitisches Krankenhaus, Hamburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.14309\/ajg.0000000000002515","article-title":"Optimizing the Management Algorithm for Adults With Functional Constipation Failing a Fiber\/Laxative Trial in General Gastroenterology: Cost-Effectiveness and Cost-Minimization Analysis","volume":"119","author":"ED Shah","year":"2024","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"ref2","doi-asserted-by":"publisher","first-page":"e14123","DOI":"10.1111\/nmo.14123","article-title":"Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation","volume":"33","author":"M Corsetti","year":"2021","journal-title":"Neurogastroenterol Motil"},{"issue":"09","key":"ref3","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1136\/gutjnl-2016-311835","article-title":"Comparison of efficacy of pharmacological treatments for chronic idiopathic constipation: a systematic review and network meta-analysis","volume":"66","author":"AD Nelson","year":"2017","journal-title":"Gut"},{"issue":"02","key":"ref4","doi-asserted-by":"publisher","first-page":"e13762","DOI":"10.1111\/nmo.13762","article-title":"European society of neurogastroenterology and motility guidelines on functional constipation in adults","volume":"32","author":"J Serra","year":"2020","journal-title":"Neurogastroenterol Motil"},{"issue":"03","key":"ref5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/17474124.2019.1568238","article-title":"Prucalopride for the treatment of constipation: a view from 2015 and beyond","volume":"13","author":"G Bassotti","year":"2019","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12876-023-03104-8","article-title":"Comparative profiles of lubiprostone, linaclotide, and elobixibat for chronic constipation: a systematic literature review with meta-analysis and number needed to treat\/harm","volume":"24","author":"SS Rao","year":"2024","journal-title":"BMC Gastroenterol"},{"issue":"09","key":"ref7","doi-asserted-by":"crossref","first-page":"e14632","DOI":"10.1111\/nmo.14632","article-title":"Plecanatide for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation: Post hoc analyses of placebo-controlled trials in adults with severe constipation","volume":"35","author":"BD Cash","year":"2023","journal-title":"Neurogastroenterol Motil"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.2147\/DDDT.S221278","article-title":"The Use of Peripheral \u03bc-Opioid Receptor Antagonists (PAMORA) in the Management of Opioid-Induced Constipation: An Update on Their Efficacy and Safety","volume":"14","author":"JV Pergolizzi","year":"2020","journal-title":"Drug Des Devel Ther"},{"issue":"07","key":"ref9","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1053\/j.gastro.2023.02.013","article-title":"Randomized Placebo-Controlled Phase 3 Trial of Vibrating Capsule for Chronic Constipation","volume":"164","author":"SSC Rao","year":"2023","journal-title":"Gastroenterology"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1055\/a-1880-1928","article-title":"Aktualisierte S2k-Leitlinie chronische Obstipation der Deutschen Gesellschaft f\u00fcr Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft f\u00fcr Neurogastroenterologie & Motilit\u00e4t (DGNM) \u2013 April 2022 \u2013 AWMF-Registriernummer: 021\u2013019","volume":"60","author":"V Andresen","year":"2022","journal-title":"Z Gastroenterol"}],"container-title":["DMW - 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