{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:08:21Z","timestamp":1785528501859,"version":"3.56.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nonalcoholic fatty liver disease and diabetes always coexist. The relationship of\n                    fatty liver and hyperglycemia is not clear. We studied the influence of\n                    hyperglycemia on triglyceride (TG) accumulation in the liver and explored its\n                    possible mechanisms. SD rats were divided into three groups: Group A (sham\n                    operation control), Group B (partially pancreatectomized rats), and Group C\n                    (partially pancreatectomized rats treated with insulin). At 4 weeks after\n                    surgery, pancreatic weights and liver TG contents were measured. Serum\n                    biochemical parameters were determined, and oral glucose tolerance tests (OGTT)\n                    were performed. The gene expression of sterol regulatory element-binding\n                    protein1c (SREBP-1c), carbohydrate regulatory element-binding protein (ChREBP),\n                    fatty acid synthase(FAS), carnitine palmitoyltransferase 1 (CPT-1), and\n                    fibroblast growth factor 21 (FGF21) was determined by real-time PCR. Compared\n                    with Group A, postprandial glucose increased significantly; the concentrations\n                    of insulin and C-peptides, pancreatic weights and serum FGF21 levels were\n                    decreased, liver TG was increased significantly in Group B, and insulin\n                    treatment improved these changes. Compared with Group A, the gene expressions of\n                    FGF21, CPT-1 and FAS in the liver were decreased in Group B (all\n                    p&lt;0.05). Compared with Group B, the gene expressions of FGF21, FAS,\n                    ChREBP, SREBP-1c and CPT-1 in the liver in Group C were all increased\n                    significantly (p&lt;0.05, respectively). Hyperglycemia induced by partial\n                    pancreatectomy could lead to increased liver TG. Insulin treatment could\n                    decrease glucose levels and improve fatty liver, and genes related to lipid\n                    metabolism may play a role in this process.<\/jats:p>","DOI":"10.1055\/a-2198-1132","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:39:27Z","timestamp":1700696367000},"page":"159-166","source":"Crossref","is-referenced-by-count":2,"title":["The Influence of Hyperglycemia on Liver Triglyceride Deposition in\n                    Partially Pancreatectomized Rats"],"prefix":"10.1055","volume":"56","author":[{"given":"Xiu-Ping","family":"Bai","sequence":"additional","affiliation":[{"name":"Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai-Li","family":"Guo","sequence":"additional","affiliation":[{"name":"Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Dong","sequence":"additional","affiliation":[{"name":"Radiation Oncology, UTHSC at San Antonio, San Antonio,\n                    USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S2213-8587(18)30154-2","article-title":"Non-alcoholic fatty liver disease: causes, diagnosis, 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Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.15252\/embj.201695417","article-title":"Fatty acid synthesis is critical for stem cell pluripotency via promoting\n                    mitochondrial fission","volume":"36","author":"L Wang","year":"2017","journal-title":"EMBO J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cphy.c130024","article-title":"Energy metabolism in the liver","volume":"4","author":"L Rui","year":"2014","journal-title":"Compr Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1210\/en.2011-0281","article-title":"Integrated regulation of hepatic metabolism by fibroblast growth factor 21\n                    (FGF21) in vivo","volume":"152","author":"F M Fisher","year":"2011","journal-title":"Endocrinology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"601290","DOI":"10.3389\/fendo.2020.601290","article-title":"FGF21: An emerging therapeutic target for 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steatosis","volume":"121","author":"A Cui","year":"2017","journal-title":"J Vis Exp"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.3748\/wjg.v26.i23.3249","article-title":"Medications in type-2 diabetics and their association with liver fibrosis","volume":"26","author":"M T Siddiqui","year":"2020","journal-title":"World J Gastroenterol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3349\/ymj.2016.57.4.885","article-title":"The relationship between type 2 diabetes mellitus and non-alcoholic fatty liver\n                    disease measured by controlled attenuation parameter","volume":"57","author":"Y E Chon","year":"2016","journal-title":"Yonsei Med J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00592-018-1266-0","article-title":"A round trip from nonalcoholic fatty liver disease to diabetes: molecular\n                    targets to the rescue?","volume":"56","author":"A 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Jensen","year":"2018","journal-title":"J Hepatol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1001\/jama.2018.20579","article-title":"Effect of a low free sugar diet vs usual diet on nonalcoholic fatty liver\n                    disease in adolescent boys: a randomized clinical trial","volume":"321","author":"J B Schwimmer","year":"2019","journal-title":"JAMA"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"G832","DOI":"10.1152\/ajpgi.00355.2015","article-title":"Fibroblast growth factor 21 and exercise-induced hepatic mitochondrial\n                    adaptations","volume":"310","author":"J A Fletcher","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1194\/jlr.M081836","article-title":"Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and\n                    lipogenesis in livers of mice","volume":"59","author":"A G Linden","year":"2018","journal-title":"J Lipid Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1055\/s-0033-1358523","article-title":"Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP","volume":"33","author":"X Xu","year":"2013","journal-title":"Semin Liver Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biochi.2004.11.008","article-title":"Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory\n                    element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism\n                    and lipid synthesis in liver","volume":"87","author":"R Dentin","year":"2005","journal-title":"Biochimie"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cmet.2019.01.004","article-title":"A dozen years of discovery: insights into the physiology and pharmacology of\n                    FGF21","volume":"29","author":"S A Kliewer","year":"2019","journal-title":"Cell Metab"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1210\/jc.2017-01257","article-title":"FGF21 is an insulin-dependent postprandial hormone in adult humans","volume":"102","author":"R J Samms","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1210\/en.2011-0281","article-title":"Integrated regulation of hepatic metabolism by fibroblast growth factor 21\n                    (FGF21) in vivo","volume":"152","author":"F M Fisher","year":"2011","journal-title":"Endocrinology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"E345","DOI":"10.1152\/ajpendo.00495.2019","article-title":"Acute insulin deprivation results in altered mitochondrial substrate sensitivity\n                    conducive to greater fatty acid transport","volume":"319","author":"P M Miotto","year":"2020","journal-title":"Am J Physiol Endocrinol Metab"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2198-1132.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:22:11Z","timestamp":1730805731000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2198-1132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":32,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,1,29]]},"published-print":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2198-1132","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,22]]}}}