{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:57:15Z","timestamp":1776722235120,"version":"3.51.2"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Postprocedural thrombocytopenia is a known phenomenon following transcatheter aortic valve implantation (TAVI). The aim of this study is to evaluate whether postinterventional platelet kinetics differ when comparing the current generation of balloon-expandable valve (BEV) and self-expanding valve (SEV) prostheses.<\/jats:p><jats:p>\n          Methods\u2003We performed a retrospective analysis of patients undergoing TAVI at our facility between 2017 and 2019. Patients were stratified according to the type of prosthesis used: BEV or SEV. Hematocrit-corrected platelet counts were calculated to account for dilution. Nadir platelet counts (lowest recorded platelet count), drop platelet counts (DPC; highest relative platelet drop from baseline), and severity of thrombocytopenia during the discourse and at discharge were assessed.<\/jats:p><jats:p>\n          Results\u2003Of the 277 included patients, 212 received SEV and 65 BEV. BEV patients were younger (81.8\u2009\u00b1\u20094.4 years vs 79.7\u2009\u00b1\u20096.8 years, p\u2009=\u20090.03). Further demographic characteristics were similar between groups. Implanted SEV were larger (p\u2009&lt;\u20090.001) and had shorter procedural times (p\u2009&lt;\u20090.01). There were no significant differences in postprocedural discourse. Postinterventional platelet drop was more pronounced in BEV patients in several evaluated metrics: mean DPC (24.3\u2009\u00b1\u200910.9% vs 18.8\u2009\u00b1\u200914.8%, p\u2009&lt;\u20090.01), patients with DPC\u2009&gt;\u200930% (n\u2009=\u200919, 29.2%, vs n\u2009=\u200933, 15.6%, p\u2009=\u20090.02), and also when comparing platelet kinetics.<\/jats:p><jats:p>\n          Conclusion\u2003Despite improvements in outcome, the current generation of balloon-expandable TAVI prostheses carries a predisposition for postprocedural thrombocytopenia even when the effects of dilution are accounted for.<\/jats:p>","DOI":"10.1055\/a-2198-1235","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T22:54:11Z","timestamp":1698274451000},"page":"264-271","source":"Crossref","is-referenced-by-count":2,"title":["Acquired Thrombocytopenia in Contemporary Transcatheter Aortic Valve Prosthesis"],"prefix":"10.1055","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6827-2489","authenticated-orcid":false,"given":"Asen","family":"Petrov","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Heart Centre Dresden, University Hospital of the University of Technology Dresden, Dresden, Sachsen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Taghizadeh-Waghefi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Heart Centre Dresden, University Hospital of the University of Technology Dresden, Dresden, Sachsen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel-Hannan","family":"Diab","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Heart Centre Dresden, University Hospital of the University of Technology Dresden, Dresden, Sachsen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Breuer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Heart Centre Dresden, University Hospital of the University of Technology Dresden, Dresden, Sachsen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Arzt","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Heart Centre Dresden, University Hospital of the University of Technology Dresden, Dresden, Sachsen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus Ehrhard","family":"Matschke","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Heart Centre Dresden, University Hospital of the University of Technology Dresden, Dresden, Sachsen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Alexiou","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Heart Centre Dresden, University Hospital of the University of Technology Dresden, Dresden, Sachsen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"issue":"24","key":"ref1","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1161\/01.CIR.0000047200.36165.B8","article-title":"Percutaneous transcatheter implantation of an aortic valve prosthesis for calcific aortic stenosis: first human case description","volume":"106","author":"A Cribier","year":"2002","journal-title":"Circulation"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"A 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