{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:29:38Z","timestamp":1767900578370,"version":"3.49.0"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective Before planned enucleation, local tumor extension in advanced retinoblastoma is routinely assessed preoperatively using high-resolution magnetic resonance imaging (MRI). The aim of our study was to analyse the predictive value of MRI and clinical characteristics for predicting tumor extent, as confirmed by histopathology postoperatively.<\/jats:p>\n                  <jats:p>Patients and Methods All consecutive patients were included who underwent primary enucleation for advanced retinoblastoma after high-resolution MRI examination in our hospital between January 2011 and December 2021. The primary study endpoint was the evaluation of the predictability of histopathological risk factors on preoperative MRI examination. The sensitivity and specificity of the MRI examination with respect to clinically relevant optic nerve infiltration and choroidal infiltration were determined.<\/jats:p>\n                  <jats:p>Results The mean age of the 209 included patients was 1.6\u00a0years (range 1 month to 4.7 years). MRI indicated optic nerve infiltration in 46 (22%) patients, extensive choroidal infiltration in 78 (40.2%) patients, and scleral infiltration in one patient (2.6%). Histopathological examination demonstrated postlaminar optic infiltration in 25 (12%) patients and extensive choroidal infiltration in 17 (8.1%) cases. Scleral infiltration was evident in 8 (3.8%) patients. In the final multivariate analysis, MRI findings of tumor infiltration and a preoperative intraocular pressure \u2265\u200920\u2009mmHg were independently associated with histopathological evidence of clinically relevant optic nerve (p\u2009=\u20090.033\/p\u2009=\u20090.011) and choroidal infiltration (p\u2009=\u20090.005\/p\u2009=\u20090.029). The diagnostic accuracy of the prediction models based on the multivariate analysis for the identification of the clinically relevant optic nerve (AUC\u2009=\u20090.755) and choroidal infiltration (AUC\u2009=\u20090.798) was greater than that of\n          purely MRI-based prediction (respectively 0.659 and 0.742). The sensitivity and specificity of MRI examination for determining histopathological risk factors in our cohort were 64% and 65% for clinically relevant optic infiltration and 87% and 64% for clinically relevant choroidal infiltration.<\/jats:p>\n                  <jats:p>Conclusion The local tumor extent of retinoblastoma with infiltration of the optic nerve and choroid can be well estimated based on radiological and clinical characteristics before treatment initiation. The combination of clinical and radiological risk factors supports the possibility of early treatment stratification in retinoblastoma patients.<\/jats:p>","DOI":"10.1055\/a-2198-7630","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T18:35:13Z","timestamp":1703270113000},"page":"1122-1131","source":"Crossref","is-referenced-by-count":1,"title":["Preoperative Detection of Local Tumor Extent in Patients with Advanced Retinoblastoma: Predictive Value of MRI and Clinical Findings"],"prefix":"10.1055","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-5077","authenticated-orcid":false,"given":"Leyla","family":"Jabbarli","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"G\u00f6ricke","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Diagnostische und Interventionelle Radiologie und Neuroradiologie, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Stumbaum","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Rating","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3244-6782","authenticated-orcid":false,"given":"Mael","family":"Lever","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Ting","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie Nordhessen, Gesundheit Nordhessen Holding AG, Kassel, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Junker","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Neuropathologie, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Bornfeld","sequence":"additional","affiliation":[{"name":"Facharztzentrum f\u00fcr Augenheilkunde, D\u00fcsseldorf, Universit\u00e4t Duisburg-Essen, Duisburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schoenberger","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinderheilkunde III, Universit\u00e4tsklinikum Essen, 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