{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:29:50Z","timestamp":1730870990393,"version":"3.28.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Einleitung Die Behandlung von Schwangeren bei drohender Fr\u00fchgeburt\n                    stellt eine interdisziplin\u00e4re Herausforderung dar. An der Grenze der\n                    Lebensf\u00e4higkeit spielen fetomaternale Risikofaktoren (RF) eine\n                    entscheidende Rolle in der individuellen Beratung und den\n                    Therapieans\u00e4tzen.<\/jats:p><jats:p>\n          Methoden An einem Level-1-Perinatalzentrum (PNZ) wurden in einer\n                    retrospektiven Beobachtungsstudie zwischen 2017 und 2020 alle\n                    Fr\u00fchgeborenen (FG) mit einem Gestationsalter (GA) zwischen\n                        230\/7 und 246\/7 Schwangerschaftswochen\n                    (SSW) erfasst, die postnatal mit einem kurativen Therapieansatz behandelt\n                    wurden. Eingeteilt in zwei Gruppen (230\/7\n                        \u2013236\/7 und\n                    240\/7\u2013246\/7 SSW) wurden die FG unter\n                    Ber\u00fccksichtigung der fetomaternalen RF hinsichtlich der\n                    Mortalit\u00e4t und Morbidit\u00e4t verglichen. Analysiert wurden 13\n                    definierte RF und deren prognostische Relevanz f\u00fcr das\n                    \u00dcberleben.<\/jats:p><jats:p>\n          Ergebnisse Es wurden 41 M\u00fctter mit 48 FG eingeschlossen.\n                    Ausgeschlossen wurden 9 FG, die prim\u00e4r palliativ behandelt wurden. Die\n                    \u00dcberlebensraten der Gruppen (n=21, n=27) zeigten keine\n                    signifikanten Unterschiede (66,7% versus 74,1%,\n                    p=0,750). Bei steigender Anzahl an RF wurde eine signifikant\n                    h\u00f6here Mortalit\u00e4t beobachtet (p=0,004), schwerwiegend\n                    waren hypertensive Schwangerschaftserkrankungen und ein vorzeitiger\n                    Blasensprung. Die Morbidit\u00e4tsdaten zeigten keine signifikanten\n                    Unterschiede.<\/jats:p><jats:p>\n          Schlussfolgerung Die vorliegenden Daten bez\u00fcglich der\n                    Mortalit\u00e4t entsprachen den nationalen Daten. Die Morbidit\u00e4t\n                    dieser FG konnte erfasst werden. Durch die Ber\u00fccksichtigung der RF\n                    l\u00e4sst sich die Vorhersage der \u00dcberlebenswahrscheinlichkeit\n                    pr\u00e4zisieren.<\/jats:p>","DOI":"10.1055\/a-2198-9124","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T23:58:23Z","timestamp":1702339103000},"page":"166-173","source":"Crossref","is-referenced-by-count":0,"title":["Einfluss von fetomaternalen Risikofaktoren auf die Mortalit\u00e4t\n                    und Morbidit\u00e4t von Extremfr\u00fchgeborenen"],"prefix":"10.1055","volume":"228","author":[{"given":"Paula","family":"Winkler","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Gyn\u00e4kologie und\n                    Geburtshilfe, Klinikum Oldenburg AoR, Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Cloppenburg","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Kinder- und Jugendmedizin,\n                    Elisabeth-Kinderkrankenhaus, Klinik f\u00fcr Neonatologie,\n                    P\u00e4diatrische Intensivmedizin, Kinderkardiologie, P\u00e4diatrische\n                    Pneumologie und Allergologie, Klinikum Oldenburg AoR, Oldenburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Heep","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Kinder- und Jugendmedizin,\n                    Elisabeth-Kinderkrankenhaus, Klinik f\u00fcr Neonatologie,\n                    P\u00e4diatrische Intensivmedizin, Kinderkardiologie, P\u00e4diatrische\n                    Pneumologie und Allergologie, Klinikum Oldenburg AoR, Oldenburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Malik","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Gyn\u00e4kologie und\n                    Geburtshilfe, Klinikum Oldenburg AoR, Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f6rte","family":"L\u00fcdders","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Frauenheilkunde und Geburtshilfe, Klinikum\n                    Starnberg, Starnberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Lange","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Kinder- und Jugendmedizin,\n                    Elisabeth-Kinderkrankenhaus, Klinik f\u00fcr Neonatologie,\n                    P\u00e4diatrische Intensivmedizin, Kinderkardiologie, P\u00e4diatrische\n                    Pneumologie und Allergologie, Klinikum Oldenburg AoR, Oldenburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3238\/arztebl.2013.0227","article-title":"Drohende Fr\u00fchgeburt: Pr\u00e4vention, Diagnostik und Therapie","volume":"110","author":"E Schleu\u00dfner","year":"2013","journal-title":"Dtsch Arztebl Int"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fped.2016.00023","article-title":"Mortality and Major Morbidity of Very-Low-Birth-Weight Infants in Germany\n                    2008-2012: A Report Based on Administrative Data","volume":"4","author":"E Jeschke","year":"2016","journal-title":"Front Pediatr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1007\/s00112-021-01294-7","article-title":"Fr\u00fchgeborene an der Grenze der Lebensf\u00e4higkeit","volume":"169","author":"C 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