{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:38:44Z","timestamp":1778312324467,"version":"3.51.4"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Endocarditis as a potentially life-threatening disease with high complication and mortality rates. In recent years, an increase in the incident of endocarditis has been reported throughout Europe. In the aging society, successful treatment is complex and challenging owing to the high rate of multimorbidity.<\/jats:p><jats:p>\n          Methods\u2003We initiated a statewide prospective multicenter endocarditis registry in 2020. Perioperative risk factors, comorbidities, microbiological, laboratory and imaging diagnostics, complications, and mortality including 1-year follow-up were collected. The present midterm analysis includes factors influencing mortality in the first 313 patients.<\/jats:p><jats:p>\n          Result\u2003In-hospital mortality and 1-year mortality were 28.4 and 40.9%, respectively. Preoperative risk factors include age (p\u2009&lt;\u20090.001), EuroSCORE II (p\u2009&lt;\u20090.001), coronary artery disease (p\u2009=\u20090.022), pacemaker probe infection (p\u2009=\u20090.033), preoperative left ventricular ejection fraction (LVEF), systemic inflammatory response syndrome (SIRS), pulmonary edema, heart failure, septic emboli, acute renal failure, impaired coagulation, hypalbuminemia (p\u2009&lt;\u20090.001), and N-terminal prohormone of brain natriuretic peptide (NTproBNP) (p\u2009=\u20090.001). The presence of peri-annular abscess, perforation, and shunt were associated with increased mortality (p\u2009=\u20090.004, 0.001, and 0.004, respectively). In addition, cardiopulmonary bypass time influenced mortality (p\u2009=\u20090.002). The main postoperative causes of death were multi-organ failure, renal failure, vasoplegia, and low-output syndrome (p\u2009&lt;\u20090.001). Previous endocarditis was 7.7%, while 35.5% were prosthetic valve recipients and 33.6% were redo surgeries.<\/jats:p><jats:p>\n          Conclusion\u2003Our first registry data show the complexity of endocarditis patients and the challenging treatment. Some risk factors can be treated preoperatively. For instance, hypalbuminemia and the duration of the procedure can be controlled with adequate albumin substitution and carefully planned procedures restricted to the essential requirements, that is, hybrid approaches with consecutive interventions.<\/jats:p>","DOI":"10.1055\/a-2199-2344","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:12:22Z","timestamp":1698361942000},"page":"587-594","source":"Crossref","is-referenced-by-count":3,"title":["New Insights into Mortality-Related Risk Factors in Infective Endocarditis: Results from the Brandenburg State Endocarditis Register"],"prefix":"10.1055","volume":"72","clinical-trial-number":[{"clinical-trial-number":"drks00023423","registry":"10.18810\/drks"}],"author":[{"given":"Roya","family":"Ostovar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Heart center Brandenburg, Faculty of Health Sciences Brandenburg, University Hospital Brandenburg Medical School Theodor Fontane, Bernau bei Berlin, Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Schroeter","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Heart center Brandenburg, Faculty of Health Sciences Brandenburg, University Hospital Brandenburg Medical School Theodor Fontane, Bernau bei Berlin, Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frarzane","family":"Seifi Zinab","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Sana Hospital, Heart Center Cottbus GmbH, Cottbus, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Fritzsche","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Sana Hospital, Heart Center Cottbus GmbH, Cottbus, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Heinrich","family":"Minden","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oberhavel Kliniken GmbH, Hennigsdorf, Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmeen","family":"Lasheen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oberhavel Kliniken GmbH, Hennigsdorf, Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hartrumpf","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Heart center Brandenburg, Faculty of Health Sciences Brandenburg, University Hospital Brandenburg Medical School Theodor Fontane, Bernau bei Berlin, Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Ritter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Health Sciences Brandenburg, University Hospital, Brandenburg Medical School Theodor Fontane, Brandenburg an der Havel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gesine","family":"D\u00f6rr","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Alexianer St. Josef Hospital Potsdam, Potsdam, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes Maximilian","family":"Albes","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Heart center Brandenburg, Faculty of Health Sciences Brandenburg, University Hospital Brandenburg Medical School Theodor Fontane, Bernau bei Berlin, Brandenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"issue":"44","key":"ref1","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","article-title":"2015 ESC guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European Society of Cardiology (ESC). 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