{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:25:05Z","timestamp":1789176305357,"version":"build-2803163510"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transition medicine aims at the coordinated transfer of young patients with a\n                    chronic disease from paediatric to adult care. The present study reflects 20\n                    years of experience in transitioning patients with congenital adrenal\n                    hyperplasia (CAH) in a single center setting. Our endocrine transition-clinic\n                    was established in 2002 and offers joint paediatric and adult consultations.\n                    Data were evaluated retrospectively from 2002 to 2005 and 2008 to present.\n                    Fifty-nine patients (29 males) were transferred. Median age was 18.4 years\n                    (17.6\u201323.6). Ninety percent of the patients presented with\n                    21-hydroxlase-deficiency (21-OHD), 38 patients (23\u2009m) with salt-wasting\n                    (sw), 7 (1\u2009m) with simple-virilising (sv) and 8 (3\u2009m) with the\n                    non-classic (nc) form. Rarer enzyme deficiencies were found in 6 cases:\n                    17\u03b1-OHD (2 sisters), P450-oxidoreductase-deficiency (2 siblings),\n                    3\u03b2-hydroxysteroid-dehydrogenase-deficiency (1\u2009m) and\n                    11\u03b2-OHD (1 female). Thirty-four patients (57.6%, 20\u2009m)\n                    are presently still attending the adult clinic, 1 patient (1.7%, m)\n                    moved away and 24 (40.7%, 8\u2009m) were lost to follow-up (13\n                    sw-21-OHD, 6 sv-21-OHD, 5 nc-21-OHD). Thirty-seven patients (62.7%)\n                    attended the adult clinic for &gt;2 years after transfer, 17\n                    (28.8%) for &gt;10 years. In the lost to follow-up group, median\n                    time of attendance was 16.3 months (0\u2013195.2). Defining a successful\n                    transfer as two or more visits in the adult department after initial\n                    consultation in the transition clinic, transfer was efficient in 84.7%\n                    of the cases. A seamless transfer to adult care is essential for adolescents\n                    with CAH. It requires a continuous joint support during the transition period,\n                    remains challenging, and necessitates adequate funding.<\/jats:p>","DOI":"10.1055\/a-2201-6548","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T23:32:57Z","timestamp":1704324777000},"page":"45-50","source":"Crossref","is-referenced-by-count":8,"title":["Transition from Paediatric to Adult Care in CAH: 20 Years of\n                    Experience at a Tertiary Referral Center"],"prefix":"10.1055","volume":"56","author":[{"given":"Cordula","family":"Kiewert","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes, Member of ENDO-ERN,\n                    University Hospital Essen, University of Duisburg-Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Jedanowski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Member of\n                    ENDO-ERN, University Hospital Essen, University of Duisburg-Essen,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold P.","family":"Hauffa","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes, Member of ENDO-ERN,\n                    University Hospital Essen, University of Duisburg-Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Petersenn","sequence":"additional","affiliation":[{"name":"ENDOC Center for Endocrine Tumors, Hamburg, Germany, and University of\n                    Duisburg-Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Member of\n                    ENDO-ERN, University Hospital Essen, University of Duisburg-Essen,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"F\u00fchrer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Member of\n                    ENDO-ERN, University Hospital Essen, University of Duisburg-Essen,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Unger","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Member of\n                    ENDO-ERN, University Hospital Essen, University of Duisburg-Essen,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1210\/jc.2010-0917","article-title":"Health status of adults with congenital adrenal hyperplasia: a cohort study of\n                    203 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Endocrinol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"986342","DOI":"10.3389\/fendo.2022.986342","article-title":"Trends in hospital admissions for adrenal insufficiency in adolescents and young\n                    adults in the 21(st) century","volume":"13","author":"G L Chrisp","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12020-022-03070-3","article-title":"Adrenal crises in adolescents and young adults","volume":"77","author":"R L Rushworth","year":"2022","journal-title":"Endocrine"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000343818","article-title":"Transition from pediatric to adult healthcare: assessment of specific needs of\n                    patients with chronic endocrine conditions","volume":"78","author":"A Godbout","year":"2012","journal-title":"Horm Res Paediatr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1210\/jc.2018-01865","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an\n                    endocrine society clinical practice guideline","volume":"103","author":"P W Speiser","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e14719","DOI":"10.1111\/dme.14719","article-title":"Growing up with type 1 diabetes mellitus: data from the Verona Diabetes\n                    Transition Project","volume":"39","author":"S Pasquini","year":"2022","journal-title":"Diabet Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.eprac.2023.01.010","article-title":"Transition readiness in adolescents and young adults living with congenital\n                    adrenal hyperplasia","volume":"29","author":"K Ekbom","year":"2023","journal-title":"Endocr Pract"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1210\/jc.2013-1440","article-title":"Approach to the patient: the adult with congenital adrenal hyperplasia","volume":"98","author":"R J Auchus","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S2213-8587(13)70138-4","article-title":"Management of adolescents with congenital adrenal hyperplasia","volume":"1","author":"D P Merke","year":"2013","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/jpepsy\/jsx142","article-title":"Barriers to transition from pediatric to adult care: a systematic review","volume":"43","author":"W N Gray","year":"2018","journal-title":"J Pediatr Psychol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jpag.2020.05.005","article-title":"Identity, sexuality, and parenthood in women with congenital adrenal\n                    hyperplasia","volume":"33","author":"H Engberg","year":"2020","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"R127","DOI":"10.1530\/EJE-18-0712","article-title":"Management of endocrine disease: diagnosis and management of the patient with\n                    non-classic CAH due to 21-hydroxylase deficiency","volume":"180","author":"A Nordenstrom","year":"2019","journal-title":"Eur J Endocrinol"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2201-6548.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:21:40Z","timestamp":1730812900000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2201-6548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":21,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,1,3]]},"published-print":{"date-parts":[[2024,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2201-6548","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}