{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:09:16Z","timestamp":1789693756434,"version":"4.0.1"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Hyperandrogenism is among the most common endocrine disorders\n                    in women. Clinically, it manifests as hirsutism, acne, and alopecia. A healthy\n                    lifestyle, including nutritious dietary patterns and physical activity, may\n                    influence the clinical manifestation of the disease. This study determined the\n                    effect of a low-glycemic index anti-inflammatory diet on testosterone levels and\n                    sex hormone-binding globulin (SHBG) and clinical symptoms in hyperandrogenic\n                    women at their reproductive age.<\/jats:p><jats:p>\n          Methods The study included 44 overweight and obese women diagnosed with\n                    hyperandrogenism. The anthropometrics (weight, height, body mass index, waist\n                    circumference, hip circumference), physical activity, and dietary habits were\n                    assessed using valid questionnaires, scales, stadiometer, and tape meter. The\n                    significant p-value was &lt;0.001. Serum testosterone and SHBG levels were\n                    measured using automated immunoassay instruments.<\/jats:p><jats:p>\n          Results The intervention based on a low-glycemic index diet with\n                    anti-inflammatory elements and slight energy deficit decreased total\n                    testosterone levels (p&lt;0.003), increased SHBG levels (p&lt;0.001),\n                    and decreased the free androgen index (FAI; p&lt;0.001). Post-intervention,\n                    overall well-being was much higher than in the pre-intervention period\n                    (p&lt;0.001), and stress was diminished (p&lt;0.001). Western\n                    nutritional patterns positively correlate with clinical hyperandrogenism\n                    progression, whereas several factors of the low-glycemic index diet with\n                    anti-inflammatory elements and slight energy deficit positively associate with\n                    reduced clinical hyperandrogenism symptoms.<\/jats:p><jats:p>\n          Conclusions In overweight and obese women, proper selection of diet,\n                    introduction of moderate physical activity, and reduction in weight, stress\n                    factors, and alcohol consumption translate into several positive effects,\n                    including reduced FAI and symptoms such as acne, hirsutism, menstrual disorders,\n                    and infertility.<\/jats:p>","DOI":"10.1055\/a-2201-8618","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T23:39:55Z","timestamp":1705621195000},"page":"6-14","source":"Crossref","is-referenced-by-count":6,"title":["Reduction in the Free Androgen Index in Overweight Women After Sixty\n                    Days of a Low Glycemic Diet"],"prefix":"10.1055","volume":"132","author":[{"given":"Barbara","family":"Zapa\u0142a","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Jagiellonian University\n                    Medical College, Krakow, Poland"},{"name":"Jagiellonian University Hospital in Krakow, Krakow,\n                    Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Marszalec","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Jagiellonian University Medical\n                    College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Piwowar","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Telemedicine, Jagiellonian University\n                    Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Chmura","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Jagiellonian University Medical\n                    College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Milewicz","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Endocrinology, Jagiellonian University\n                    Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"Task force on the phenotype of the polycystic ovary syndrome of The Androgen\n                    Excess and PCOS Society. The Androgen Excess and PCOS Society criteria for the\n                    polycystic ovary syndrome: The complete task force report","volume":"91","author":"R Azziz","year":"2009","journal-title":"Fertil Steril"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1210\/jc.2005-1457","article-title":"Extensive clinical experience: Relative prevalence of different androgen excess\n                    disorders in 950 women referred because of clinical hyperandrogenism","volume":"91","author":"E Carmina","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"24","author":"D A Ehrmann","year":"2005","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0002-9378(81)90746-8","article-title":"Hirsutism: Implications, etiology and management","volume":"140","author":"R Hatch","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0015-0282(16)45429-4","article-title":"Polycystic ovary disease","volume":"35","author":"J W Goldzieher","year":"1981","journal-title":"Fertil Steril"},{"key":"ref6","first-page":"273","article-title":"Evaluation of hirsutism and hyperandro-genemia","volume":"36","author":"G B Maroulis","journal-title":"Fertil Steril"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"851","DOI":"10.7326\/0003-4819-97-6-851","article-title":"Insulin resistance associated with androgen excess in women with autoantibodies\n                    to the insulin receptor","volume":"97","author":"Sl Taylor","year":"1982","journal-title":"Ann Intern Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0002-9378(83)90091-1","article-title":"Hyperandrogenism, insulin resistance and acanthosis nigricans syndrome: A common\n                    endocrinopathy with distinct pathophysiological features","volume":"147","author":"R L Barbieri","year":"1983","journal-title":"Am J Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1210\/edrv.20.4.0374","article-title":"The insulin-related ovarian regulatory system in health and disease","volume":"20","author":"L Poretsky","year":"1999","journal-title":"Endocr Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/07853890410035296","article-title":"Insulin resistance in patients with polycystic ovary syndrome","volume":"36","author":"A K Schr\u00f6der","year":"2004","journal-title":"Ann Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.4158\/EP15748.DSC","article-title":"American Association of Clinical Endocrinologists (AACE); American College of\n                    Endocrinology (ACE); Androgen Excess and PCOS Society (AES). Guide to the best\n                    practices in the evaluation and treatment of polycystic ovary syndrome-part\n                    1","volume":"21","author":"N F Goodman","year":"2015","journal-title":"Endocr Pract"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/humupd\/7.6.522","article-title":"Polycystic ovary syndrome and cancer","volume":"7","author":"A Balen","year":"2001","journal-title":"Hum Reprod Update"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.beem.2006.02.004","article-title":"Diagnosis of hyperandrogenism: Clinical criteria","volume":"20","author":"B O Yildiz","year":"2006","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0140-6736(64)92789-8","article-title":"The prevalence of hirsutism in young women","volume":"1","author":"E McKnight","year":"1964","journal-title":"Lancet"},{"key":"ref15","first-page":"3078","article-title":"Prevalence of the polycystic ovary syndrome in unselected black and white women\n                    of the southeastern United States: A prospective study","volume":"83","author":"E S Knochenhauer","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/pgmj.69.809.186","article-title":"Quality of life of hirsute women","volume":"69","author":"N Sonino","year":"1993","journal-title":"Postgrad Med J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1089\/jwh.1.1999.8.1091","article-title":"Patient-perceived importance of negative effects of androgenetic alopecia in\n                    women","volume":"8","author":"C J Girman","year":"1999","journal-title":"J Womens Health Gend Based Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/00325481.1995.11945949","article-title":"Hirsutism and virilization. A systematic approach to benign and potentially\n                    serious causes","volume":"97","author":"P B Marshburn","year":"1995","journal-title":"Postgrad Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/humupd\/dmh018","article-title":"Improving reproductive performance in overweight\/obese women with\n                    effective weight management","volume":"10","author":"R J Norman","year":"2004","journal-title":"Hum Reprod Update"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3121\/cmr.2.1.13","article-title":"Polycystic ovarian syndrome: Diagnosis and management","volume":"2","author":"M T Sheehan","year":"2004","journal-title":"Clin Med Res"},{"key":"ref21","first-page":"S54","article-title":"Diabetes Canada Clinical Practice Guidelines Expert Committee, Physical Activity\n                    and Diabetes","volume":"42","author":"R J Sigal","year":"2018","journal-title":"Can J Diabetes"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.fertnstert.2003.08.023","article-title":"A randomized trial of the effects of two types of short-term hypocaloric diets\n                    on weight loss in women with polycystic ovary syndrome","volume":"81","author":"K Stamets","year":"2004","journal-title":"Fertil Steril"},{"key":"ref23","first-page":"04","article-title":"The polycystic ovary syndrome: A position statement from the Polish Society of\n                    Endocrinology, the Polish Society of Gynaecologists and Obstetricians, and the\n                    Polish Society of Gynaecological Endocrinology","volume":"69","author":"A Milewicz","year":"2018","journal-title":"Endokrynol Pol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12902-022-01208-y","article-title":"Lifestyle management in polycystic ovary syndrome \u2013 beyond diet and\n                    physical activity","volume":"23","author":"S Cowan","year":"2023","journal-title":"BMC Endocr Disord"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jand.2012.11.018","article-title":"Dietary composition in the treatment of polycystic ovary syndrome: A systematic\n                    review to inform evidence\u2011based guidelines","volume":"113","author":"L J Moran","year":"2013","journal-title":"J Acad Nutr Diet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/humrep\/dey256","article-title":"Recommendations from the international evidence\u2011based guideline for the as\n                    sessment and management of polycystic ovary syndrome","volume":"33","author":"H J Teede","year":"2018","journal-title":"Hum Reprod"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.2337\/dc08-1239","article-title":"International tables of glycemic index and glycemic load values: 2008","volume":"31","author":"F S Atkinson","year":"2008","journal-title":"Diabetes Care"},{"key":"ref28","first-page":"5","volume-title":"Dietary Assessment Methodology. In: Coulston AM, Boushey CJ, Ferruzzi MG, eds.\n                    Nutrition in the prevention and treatment of disease","author":"F E Thompson","year":"2013"},{"key":"ref31","first-page":"202","article-title":"Fat distribution and body weight","author":"G A Bray","year":"1993","journal-title":"Obesity Research"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12902-019-0420-1","article-title":"Does a restricted energy low glycemic index diet have a different effect on\n                    overweight women with or without polycystic ovary syndrome?","volume":"19","author":"F Shishehgar","year":"2019","journal-title":"BMC Endocr Disord"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"310","DOI":"10.4103\/1947-2714.161246","article-title":"Anti-inflammatory dietary combo in overweight and obese women with polycystic\n                    ovary syndrome","volume":"7","author":"A A Salama","year":"2015","journal-title":"N Am J Med Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.3390\/nu12071953","article-title":"Obesity, insulin resistance, and hyperandrogenism mediate the link between poor\n                    diet quality and ovarian dysmorphology in reproductive-aged women","volume":"12","author":"M Kazemi","year":"2020","journal-title":"Nutrients"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.fertnstert.2008.01.035","article-title":"Comparison of hormonal and metabolic markers after a high-fat, Western meal\n                    versus a low-fat, high-fiber meal in women with polycystic ovary syndrome","volume":"91","author":"H I Katcher","year":"2009","journal-title":"Fertil Steril"},{"key":"ref36","first-page":"25","article-title":"Reducing bioavailable sex hormones through a comprehensive change in diet: the\n                    diet and androgens (DIANA) randomized trial","volume":"10","author":"F Berrino","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12902-019-0434-8","article-title":"Barriers and facilitators to weight management in overweight and obese women\n                    living in Australia with PCOS: A qualitative study","volume":"19","author":"S Lim","year":"2019","journal-title":"BMC Endocr Disord"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1200\/JCO.2011.37.9792","article-title":"Reduced-calorie dietary weight loss, exercise, and sex hormones in\n                    postmenopausal women: Randomized controlled trial","volume":"30","author":"K L Campbell","year":"2012","journal-title":"J Clin Oncol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.fertnstert.2005.08.045","article-title":"Role of diet in the treatment of polycystic ovary syndrome","volume":"85","author":"C C Douglas","year":"2006","journal-title":"Fertil Steril"},{"key":"ref40","first-page":"409","article-title":"Improvement in anthropometric parameters after rational dietary intervention in\n                    women with polycystic ovary syndrom as the best method to support treatment","volume":"68","author":"M Szczuko","year":"2017","journal-title":"Rocz Panstw Zakl Hig"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.3390\/nu12061759","article-title":"Relationship between diet, menstrual pain and other menstrual characteristics\n                    among Spanish students","volume":"12","author":"M D Onieva-Zafra","year":"2020","journal-title":"Nutrients"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1530\/EC-14-0010","article-title":"Effect of lifestyle intervention on the reproductive endocrine profile in women\n                    with polycystic ovarian syndrome: A systematic review and meta-analysis","volume":"3","author":"L Haqq","year":"2014","journal-title":"Endocr Connect"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12672-014-0191-0","article-title":"The association of reproductive and lifestyle factors with a score of multiple\n                    endogenous hormones","volume":"5","author":"A L Shafrir","year":"2014","journal-title":"Horm Cancer"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1210\/jc.2015-2778","article-title":"Randomized controlled trial of preconception interventions in infertile women\n                    with polycystic ovary syndrome","volume":"100","author":"R S Legro","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1210\/jc.2016-1659","article-title":"Benefit of delayed fertility therapy with preconception weight loss over\n                    immediate therapy in obese women with PCOS","volume":"101","author":"S Richard","year":"2016","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2201-8618.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:31:07Z","timestamp":1730806267000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2201-8618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":43,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,1,18]]},"published-print":{"date-parts":[[2024,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2201-8618","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}