{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:29:26Z","timestamp":1730870966572,"version":"3.28.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaplasmosis is a vector-borne disease caused by Anaplasma (A.) spp. which\n                    currently is still rarely diagnosed in cats. This article describes 3\n                    independent cases of anaplasmosis in cats from different regions of Germany\n                    presented to veterinarians in 2021. All cats showed unspecific clinical signs,\n                    such as fever, reduced general condition, and decreased appetite. One cat\n                    additionally had generalized limb pain, another showed reluctance to move as\n                    well as vomiting. On complete blood cell count, only 1 of 3 cats showed mild\n                    thrombocytopenia. A. phagocytophilum was detected in blood samples of all\n                    3 cats by polymerase chain reaction. Additionally, in 2 cats (in which blood\n                    smears were evaluated) morulae could be detected within neutrophilic\n                    granulocytes. Initially, all 3 cats had highly elevated serum amyloid A (SAA)\n                    concentrations. Treatment with doxycycline caused a rapid improvement of\n                    clinical signs, followed by a decrease of SAA concentrations to normal levels as\n                    well as negative PCR results after a treatment duration of at least 28 days. In\n                    cats with fever, otherwise unspecific clinical signs with only mild or no\n                    hematological changes, elevated SAA concentrations, and previous exposure to\n                    ticks, attending veterinarians should consider anaplasmosis as differential\n                    diagnosis.<\/jats:p>","DOI":"10.1055\/a-2202-4956","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:05:27Z","timestamp":1709078727000},"page":"40-47","source":"Crossref","is-referenced-by-count":1,"title":["Anaplasma phagocytophilum infection associated with strong\n                    inflammatory response in 3 cats"],"prefix":"10.1055","volume":"52","author":[{"given":"Vera","family":"Geisen","sequence":"additional","affiliation":[{"name":"LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine,\n                    Ludwig Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikola","family":"Pantchev","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories, Kornwestheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Wuelfing","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories, Kornwestheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"W\u00fcrthner","sequence":"additional","affiliation":[{"name":"Small Animal Practice, Tuttlingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Gierschner","sequence":"additional","affiliation":[{"name":"Small Animal Practice, Gevelsberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Urban","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories, Kornwestheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Lambach","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories, Kornwestheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine,\n                    Ludwig Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"Bergmann","sequence":"additional","affiliation":[{"name":"LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine,\n                    Ludwig Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1053\/jfms.2001.0149","article-title":"Arthropod-transmitted infectious diseases of cats","volume":"3","author":"S E Shaw","year":"2001","journal-title":"J Feline Med Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1099\/00207713-51-6-2145","article-title":"Reorganization of genera in the families Rickettsiaceae and\n                        Anaplasmataceae in the order Rickettsiales: unification of\n                    some species of Ehrlichia with Anaplasma, Cowdria with\n                        Ehrlichia and Ehrlichia with Neorickettsia,\n                    descriptions of six new species combinations and designation of Ehrlichia\n                    equi and 'HGE agent' as subjective synonyms of Ehrlichia\n                        phagocytophila","volume":"51","author":"J S Dumler","year":"2001","journal-title":"Int J Syst Evol Microbiol"},{"key":"ref3","first-page":"776","article-title":"Tick-transmitted, bacterial infections in dogs: Seroprevalence of Anaplasma\n                        phagocytophilum, Borrelia burgdorferi sensu lato and Ehrlichia\n                        canis in Germany","volume":"88","author":"I Krupka","year":"2007","journal-title":"Der Praktische Tierarzt"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13071-022-05316-5","article-title":"Seropositivity of main vector-borne pathogens in dogs across Europe","volume":"15","author":"G Miro","year":"2022","journal-title":"Parasit Vectors"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X211017459","article-title":"Anaplasma phagocytophilum in domestic cats from Germany, Austria and\n                    Switzerland and clinical\/laboratory findings in 18 PCR-positive cats\n                    (2008-2020)","author":"I Sch\u00e4fer","year":"2021","journal-title":"J Feline Med Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1177\/1098612x15571148","article-title":"Anaplasma phagocytophilum infection of domestic cats: 16 cases from the\n                    northeastern USA","volume":"18","author":"C Savidge","year":"2016","journal-title":"J Feline Med Surg"},{"key":"ref7","first-page":"205","article-title":"Infektion mit Anaplasma phagocytophilum bei einer Katze","volume":"64","author":"I Sch\u00e4fer","year":"2019","journal-title":"Kleintierpraxis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1086\/517829","article-title":"Duration of tick attachment required for transmission of granulocytic\n                    ehrlichiosis","volume":"177","author":"P Katavolos","year":"1998","journal-title":"J Infect Dis"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1086\/318818","article-title":"Effect of tick removal on transmission of Borrelia burgdorferi and\n                        Ehrlichia phagocytophila by Ixodes scapularis nymphs","volume":"183","author":"F des Vignes","year":"2001","journal-title":"J Infect Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1136\/vr.c2546","article-title":"C-reactive protein as a marker in canine granulocytic anaplasmosis","volume":"166","author":"N Pantchev","year":"2010","journal-title":"Vet Rec"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/vcp.12451","article-title":"Acute phase proteins response in cats naturally infected with Hepatozoon\n                        felis and Babesia vogeli","volume":"46","author":"H Vilhena","year":"2017","journal-title":"Vet Clin Pathol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cimid.2017.11.001","article-title":"Acute phase proteins response in cats naturally infected by hemotropic\n                    mycoplasmas","volume":"56","author":"H Vilhena","year":"2018","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/v13112228","article-title":"Curing cats with feline infectious peritonitis with an oral multi-component drug\n                    containing GS-441524","volume":"13","author":"D Krentz","year":"2021","journal-title":"Viruses"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1177\/1040638715593598","article-title":"Evidence of Anaplasma phagocytophilum and Borrelia burgdorferi\n                    infection in cats after exposure to wild-caught adult Ixodes scapularis","volume":"27","author":"M R Lappin","year":"2015","journal-title":"J Vet Diagn Invest"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"893","DOI":"10.2460\/javma.2004.225.893","article-title":"Molecular and serologic evidence of Anaplasma phagocytophilum infection\n                    in cats in North America","volume":"225","author":"M R Lappin","year":"2004","journal-title":"J Am Vet Med Assoc"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cimid.2015.08.003","article-title":"Prevalence of selected rickettsial infections in cats in Southern Germany","volume":"42","author":"M Bergmann","year":"2015","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"ref19","first-page":"163","article-title":"Seroprevalence and bacteremia [corrected] of Anaplasma phagocytophilum in\n                    cats from Bavaria and Lower Saxony (Germany)","volume":"125","author":"D Hamel","year":"2012","journal-title":"Berl Munch Tierarztl Wochenschr"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1177\/1098612x20917600","article-title":"Anaplasma phagocytophilum infection in cats: A literature review to raise\n                    clinical awareness","volume":"22","author":"I Sch\u00e4fer","year":"2020","journal-title":"J Feline Med Surg"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"4822","DOI":"10.1128\/AAC.48.12.4822-4828.2004","article-title":"Evaluation of antibiotic susceptibilities of Ehrlichia canis,\n                        Ehrlichia chaffeensis, and Anaplasma phagocytophilum by\n                    real-time PCR","volume":"48","author":"S Branger","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1136\/vr.143.15.412","article-title":"Early manifestations of granulocytic ehrlichiosis in dogs inoculated\n                    experimentally with a Swedish Ehrlichia species isolate","volume":"143","author":"A Egenvall","year":"1998","journal-title":"Vet Rec"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1007\/s00436-015-4513-0","article-title":"Tick-borne diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and\n                    Austrian dogs: Status quo and review of ristribution, transmission, clinical\n                    findings, diagnostics and prophylaxis","volume":"114","author":"N Pantchev","year":"2015","journal-title":"Parasitol Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1111\/j.1939-1676.2008.0180.x","article-title":"Clinical features of canine granulocytic anaplasmosis in 18 naturally infected\n                    dogs","volume":"22","author":"B Kohn","year":"2008","journal-title":"J Vet Intern Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1086\/323811","article-title":"The serological response of patients infected with the agent of human\n                    granulocytic ehrlichiosis","volume":"34","author":"J S Bakken","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1177\/1098612X18758594","article-title":"Haemoplasmosis in cats: European guidelines from the ABCD on prevention and\n                    management","volume":"20","author":"S Tasker","year":"2018","journal-title":"J Feline Med Surg"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/jvim.16376","article-title":"Associations between presence of Bartonella species deoxyribonucleic acid and\n                    complete blood cell count and serum biochemical changes in client-owned\n                    cats","volume":"36","author":"M Williams","year":"2022","journal-title":"J Vet Intern Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0167-5699(94)90138-4","article-title":"The major acute phase reactants: C-reactive protein, serum amyloid P component\n                    and serum amyloid A protein","volume":"15","author":"D M Steel","year":"1994","journal-title":"Immunol Today"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1292\/jvms.65.545","article-title":"Evaluation of feline serum amyloid A (SAA) as an inflammatory marker","volume":"65","author":"K Sasaki","year":"2003","journal-title":"J Vet Med Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/jsap.12787","article-title":"Granulocytic anaplasmosis in 63 dogs: clinical signs, laboratory results,\n                    therapy and course of disease","volume":"59","author":"A Chirek","year":"2018","journal-title":"J Small Anim Pract"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1111\/j.1939-1676.2009.0384.x","article-title":"Canine granulocytic anaplasmosis: a review","volume":"23","author":"D D Carrade","year":"2009","journal-title":"J Vet Intern Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.2460\/javma.234.12.1559","article-title":"Anaplasma phagocytophilum infection in dogs: 34 cases (2000-2007)","volume":"234","author":"J L Granick","year":"2009","journal-title":"J Am Vet Med Assoc"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1111\/jvim.12445","article-title":"Comparison of serum concentrations of symmetric dimethylarginine and creatinine\n                    as kidney function biomarkers in cats with chronic kidney disease","volume":"28","author":"J A Hall","year":"2014","journal-title":"J Vet Intern Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"451","DOI":"10.17236\/sat00266","article-title":"[Diagnostic utility of creatine kinase elevation in the routine biochemical\n                    profile in cats]","volume":"162","author":"S Rusterholz","year":"2020","journal-title":"Schweiz Arch Tierheilkd"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1186\/s12879-021-06869-z","article-title":"Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report","volume":"21","author":"J M Cho","year":"2021","journal-title":"BMC Infect Dis"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1177\/1098612x17706462","article-title":"Anaplasma, Ehrlichia and Rickettsia species infections in cats: European\n                    guidelines from the ABCD on prevention and management","volume":"19","author":"M G Pennisi","year":"2017","journal-title":"J Feline Med Surg"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1136\/vr.101031","article-title":"Side effects suspected to be related to doxycycline use in cats","volume":"172","author":"B S Schulz","year":"2013","journal-title":"Vet Rec"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe K: Kleintiere \/ Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2202-4956.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T15:59:39Z","timestamp":1730822379000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2202-4956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":35,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,2,27]]},"published-print":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2202-4956","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"type":"print","value":"1434-1239"},{"type":"electronic","value":"2567-5842"}],"subject":[],"published":{"date-parts":[[2024,2]]}}}