{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:49:55Z","timestamp":1790650195096,"version":"4.1.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Purpose\u2002To compare the therapeutic response and clinical outcome of CT-guided percutaneous microwave (MWA) and radiofrequency ablation (RFA) for the treatment of small- and medium-sized HCC.<\/jats:p><jats:p>\n            Materials and Methods\u2002In this prospective trial, 50 patients with HCC were randomly assigned to MWA or RFA treatment. MRI was performed 24\u200ah before and after ablation and subsequently in 3-month intervals. Ablation volumes, ablation durations, adverse events (AE), technique efficacy, technical success, local tumor progression (LTP), disease-free survival (DFS), intrahepatic distant recurrence (IDR), and overall survival (OS) rates were evaluated.<\/jats:p><jats:p>\n            Results\u2002The mean ablation volume was 66.5\u200acm\u00b3 for MWA and 29.2 \u200acm\u00b3 for RFA (p\u200a&lt;\u200a0.01). The mean ablation durations for MWA and RFA were 11.2\u200a\u00b1\u200a4.0\u200amin and 16.3\u200a\u00b1\u200a4.7\u200amin, respectively (p\u200a&lt;\u200a0.01). Six mild AEs were documented (p\u200a&gt;\u200a0.05). All treatments had a technical success rate and a technique efficacy rate of 100\u200a% (50\/50, p\u200a=\u200a1.00). LTP within 2 years occurred in 1\/25 (4\u200a%) in the MWA group and in 4\/25 (16\u200a%) in the RFA group (p\u200a=\u200a0.06). IDR within 2 years was 8\/25 (32\u200a%) for MWA and 14\/25 (56\u200a%) for RFA (p\u200a&lt;\u200a0.05). The median DFS was 24.5\u00a0months and 13.4 months for MWA and RFA, respectively (p\u200a=\u200a0.02). The 1-, 2-, 3-year OS rates were 100\u200a%, 80\u200a%, 72\u200a% in the MWA group and 72\u200a%, 64\u200a%, 60\u200a% in the RFA group, respectively (p\u200a\u2265\u200a0.14).<\/jats:p><jats:p>\n            Conclusion\u2002The clinical outcome after MWA or RFA for HCC treatment was very similar with no significant differences in LTP or OS.\u200aHowever, MWA shows a trend toward better DFS with fewer IDRs than RFA.<\/jats:p><jats:p>\n            Key Points:\u2002<\/jats:p>","DOI":"10.1055\/a-2203-2733","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T00:40:21Z","timestamp":1702082421000},"page":"482-490","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of Microwave and Radiofrequency Ablation for the Treatment of Small- and Medium-Sized Hepatocellular Carcinomas in a Prospective Randomized Trial"],"prefix":"10.1055","volume":"196","author":[{"given":"Thomas J.","family":"Vogl","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon S.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Gruber-Rouh","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Booz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitali","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour-Eldin A.","family":"Nour-Eldin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Germany"},{"name":"Department of Diagnostic and Interventional Radiology, Cairo University, Faculty of Medicine, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N.","family":"Hussainy Said","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.crad.2017.01.013","article-title":"Loco-regional treatment of HCC: current status","volume":"72","author":"L Crocetti","year":"2017","journal-title":"Clin Radiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1053\/j.gastro.2015.12.041","article-title":"Evidence-Based Diagnosis, Staging, and Treatment of Patients With Hepatocellular Carcinoma","volume":"150","author":"J Bruix","year":"2016","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1245\/s10434-008-0071-3","article-title":"Bridging locoregional therapy for 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