{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:40:47Z","timestamp":1772631647746,"version":"3.50.1"},"reference-count":55,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background To compare clinical, anatomical, and densitometric changes following\n          Dresden (DCXL) vs. accelerated (ACXL) corneal UVA cross-linking (CXL; Avedro KXL, Geuder,\n          Heidelberg, Germany) in progressive keratoconus (KC).<\/jats:p><jats:p>\n          Methods and Material In this retrospective study, we analyzed 20 patients\n          following DCXL (3\u2009mW\/cm\u00b2, 30\u2009min, 5.4\u2009J\/cm\u00b2) and 44 patients following ACXL (9\u2009mW\/cm\u00b2,\n          10\u2009min, 5.4\u2009J\/cm\u00b2) between January 2016 and February 2020. Uncorrected visual acuity\n          (UCVA), best spectacle-corrected visual acuity (BSCVA), central corneal thickness (CCT),\n          steepest keratometry (Kmax), keratoconus index (KI), thinnest pachymetry\n          (Pthin), and corneal densitometry (CD) were measured before and 3, 6, 12, and 24 months\n          after CXL.<\/jats:p><jats:p>\n          Results During the follow-up period, no changes in UCVA, BSCVA, Kmax,\n          KI, or Pthin occurred. CCT significantly decreased 3 months after DCXL (p\u2009=\u20090.032) and\n          ACXL (p\u2009=\u20090.006). At the 12- and 24-month follow-up, CCT remained decreased in the DCXL\n          (p\u2009=\u20090.035, 0.036, respectively) but not in the ACXL group. At the 12-month follow-up, the\n          reduction in CCT was significantly greater in DCXL compared to ACXL (p\u2009=\u20090.012). At the\n          3-, 6-, 12-, and 24-month follow-ups, we found a significant increase in the anterior\n          stroma CD following DCXL (p\u2009=\u20090.019, 0.026, 0.049, 0.047, respectively) but not ACXL. The\n          CD changes were localized in the central concentric zones (0.0 to 6.0\u2009mm). No intra- or\n          postoperative complications occurred.<\/jats:p><jats:p>\n          Conclusion ACXL and DCXL effectively halted KC progression. ACXL proved to be a\n          safe time-saving alternative to conventional DCXL. DCXL led to a reduction in CCT and an\n          increment in the CD of the central anterior stroma during 24\u2009months of follow-up.<\/jats:p>","DOI":"10.1055\/a-2206-1420","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T23:40:48Z","timestamp":1705534848000},"page":"209-220","source":"Crossref","is-referenced-by-count":5,"title":["Clinical, Anatomical, and Densitometric Changes following Dresden vs.\n          Accelerated Corneal Cross-Linking in Progressive Keratoconus"],"prefix":"10.1055","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3473-7997","authenticated-orcid":false,"given":"Julia","family":"Prinz","sequence":"additional","affiliation":[{"name":"Clinic of Ophthalmology, University Hospital Aachen, Aachen,\n          Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kuerten","sequence":"additional","affiliation":[{"name":"Clinic of Ophthalmology, University Hospital Aachen, Aachen,\n          Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Schellhase","sequence":"additional","affiliation":[{"name":"Clinic of Ophthalmology, University Hospital Aachen, Aachen,\n          Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonis","family":"Koutsonas","sequence":"additional","affiliation":[{"name":"Clinic of Ophthalmology, University Hospital Aachen, Aachen,\n          Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7402-7001","authenticated-orcid":false,"given":"Yassin","family":"Djalali-Talab","sequence":"additional","affiliation":[{"name":"Clinic of Ophthalmology, University Hospital Aachen, Aachen,\n          Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Walter","sequence":"additional","affiliation":[{"name":"Clinic of Ophthalmology, University Hospital Aachen, Aachen,\n          Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Fuest","sequence":"additional","affiliation":[{"name":"Clinic of Ophthalmology, University Hospital Aachen, Aachen,\n          Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1136\/bjophthalmol-2017-311391","article-title":"Prevalence of keratoconus in paediatric patients in Riyadh, Saudi Arabia","volume":"102","author":"E A Torres Netto","year":"2018","journal-title":"Br J Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/09286586.2011.560747","article-title":"Prevalence and associated factors of keratoconus in Jerusalem: a cross-sectional\n          study","volume":"18","author":"M Millodot","year":"2011","journal-title":"Ophthalmic 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Cummings","year":"2016","journal-title":"Cornea"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ajo.2015.05.019","article-title":"Current Protocols of Corneal Collagen Cross-Linking: Visual, Refractive, and Tomographic\n          Outcomes","volume":"160","author":"R Shetty","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s00417-018-3922-z","article-title":"Correlation between central stromal demarcation line depth and changes in K values after\n          corneal cross-linking (CXL)","volume":"256","author":"N Pircher","year":"2018","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s10792-016-0423-0","article-title":"Accelerated versus conventional corneal collagen cross-linking in patients with\n          keratoconus: an intrapatient comparative study","volume":"38","author":"M M 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Ophthalmol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s12886-017-0610-4","article-title":"Differences in corneal clinical findings after standard and accelerated cross-linking in\n          patients with progressive keratoconus","volume":"17","author":"K U Kortuem","year":"2017","journal-title":"BMC Ophthalmol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.jcrs.2016.04.019","article-title":"Natural history of corneal haze after corneal collagen crosslinking in keratoconus using\n          Scheimpflug analysis","volume":"42","author":"B Z Kim","year":"2016","journal-title":"J Cataract Refract Surg"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1097\/ico.0000000000001362","article-title":"Changes in Corneal Density After Accelerated Corneal Collagen Cross-linking With\n          Different Irradiation Intensities and Energy Exposures: 1-Year Follow-up","volume":"36","author":"S Akkaya Turhan","year":"2017","journal-title":"Cornea"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"869015","DOI":"10.1155\/2011\/869015","article-title":"Complications of corneal collagen cross-linking","volume":"2011","author":"S Dhawan","year":"2011","journal-title":"J Ophthalmol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12886-019-1085-2","article-title":"Effect of the retention ring-assisted continuous application of riboflavin in\n          pulsed-light accelerated corneal collagen cross-linking on the progression of\n          keratoconus","volume":"19","author":"C Y Kim","year":"2019","journal-title":"BMC Ophthalmol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s40662-021-00240-8","article-title":"Long term results of accelerated 9\u2009mW corneal crosslinking for early progressive\n          keratoconus: the Siena Eye-Cross Study 2","volume":"8","author":"C Mazzotta","year":"2021","journal-title":"Eye Vis (Lond)"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/eye.2014.56","article-title":"Effects and adverse events after CXL for keratoconus are independent of age: a 1-year\n          follow-up study","volume":"28","author":"P B Baenninger","year":"2014","journal-title":"Eye (Lond)"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"638","DOI":"10.3928\/1081597x-20091111-01","article-title":"Sequential in vivo confocal microscopy study of corneal wound healing after\n          cross-linking in patients with keratoconus","volume":"26","author":"J O Croxatto","year":"2010","journal-title":"J Refract Surg"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/01.ico.0000105827.85025.7f","article-title":"Collagen fiber diameter in the rabbit cornea after collagen crosslinking by\n          riboflavin\/UVA","volume":"23","author":"G Wollensak","year":"2004","journal-title":"Cornea"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00003226-200401000-00008","article-title":"Keratocyte apoptosis after corneal collagen cross-linking using riboflavin\/UVA\n          treatment","volume":"23","author":"G Wollensak","year":"2004","journal-title":"Cornea"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1097\/ICO.0b013e3182199d7e","article-title":"Limbal and conjunctival epithelium after corneal cross-linking using riboflavin and\n          UVA","volume":"30","author":"G Wollensak","year":"2011","journal-title":"Cornea"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.jtos.2015.04.007","article-title":"In Vivo Confocal Microscopy after Corneal Collagen Crosslinking","volume":"13","author":"C Mazzotta","year":"2015","journal-title":"Ocul Surf"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/j.1442-9071.2007.01536.x","article-title":"Stromal haze after combined riboflavin-UVA corneal collagen cross-linking in\n          keratoconus: in vivo confocal microscopic evaluation","volume":"35","author":"C Mazzotta","year":"2007","journal-title":"Clin Exp Ophthalmol"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr 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