{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:40:07Z","timestamp":1730810407260,"version":"3.28.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective Antithyroid drug (ATD)-induced agranulocytosis (TIA) is the most\n                    serious adverse effect during ATD treatment of Graves\u2019 disease (GD).\n                    Previously, the MICA gene was reported to be associated with TIA.\n                        MICA protein is an important ligand for the NKG2D protein, which is\n                    encoded by the KLRK1 gene and KLRC4-KLRK1 read-through\n                    transcription. This study further investigated the association between\n                        KLRC4-KLRK1 gene polymorphisms and susceptibility to TIA.<\/jats:p><jats:p>\n          Methods Twenty-eight candidate single nucleotide polymorphisms (SNPs) on\n                        KLRC4-KLRK1 read-through transcription were evaluated by the iPLEX\n                    MassARRAY system in 209 GD control patients and 38 TIA cases.<\/jats:p><jats:p>\n          Results A significant association of rs2734565 polymorphism with TIA was\n                    found (p=0.02, OR=1.80, 95%\n                    CI=1.09\u20132.96). The haplotype C-A-A-C-G, including rs2734565-C,\n                    was associated with a significantly higher risk of TIA (p=4.79E-09,\n                    OR=8.361, 95% CI=3.737\u201318.707). In addition, the\n                    interval time from hyperthyroidism to agranulocytosis onset was shorter in\n                    patients carrying the rs2734565-C allele than in non-carrying groups (45.00\n                    (14.00\u20136570.00) d vs. 1080.00 (30.00\u20133600.00) d,\n                        p=0.046), and the interval from ATD treatment to\n                    agranulocytosis onset was also shorter in patients carrying rs2734565-C allele\n                    (29.00 (13.00\u201375.00) d vs. 57.50 (21.00\u2013240.00) d,\n                        p=0.023).<\/jats:p><jats:p>\n          Conclusions The findings suggest that the KLRC4-KLRK1 gene\n                    polymorphism is associated with susceptibility and progression of ATD-induced\n                    agranulocytosis. Patients carrying the rs2734565-C allele had a higher\n                    susceptibility and faster onset time of TIA.<\/jats:p>","DOI":"10.1055\/a-2206-2242","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T23:39:55Z","timestamp":1705621195000},"page":"17-22","source":"Crossref","is-referenced-by-count":0,"title":["Novel Association of KLRC4-KLRK1 Gene Polymorphisms with\n                    Susceptibility and Progression of Antithyroid Drug-Induced\n                    Agranulocytosis"],"prefix":"10.1055","volume":"132","author":[{"given":"Yayi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the First Affiliated Hospital of\n                    Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Medicine & Forensic, Health Science Center,\n                    Xi\u2019an Jiaotong University, Xi\u2019an, China"},{"name":"Kunming Center for Medical Service Quality Assessment, Kunming,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanlin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the First Affiliated Hospital of\n                    Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Medicine & Forensic, Health Science Center,\n                    Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayang","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Medicine & Forensic, Health Science Center,\n                    Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Medicine & Forensic, Health Science Center,\n                    Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the First Affiliated Hospital of\n                    Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Medicine & Forensic, Health Science Center,\n                    Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Medicine & Forensic, Health Science Center,\n                    Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the First Affiliated Hospital of\n                    Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Medicine & Forensic, Health Science Center,\n                    Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1056\/NEJMra042972","article-title":"Antithyroid drugs","volume":"352","author":"D S Cooper","year":"2005","journal-title":"N Engl J 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                   in Kinh Vietnamese patients","volume":"2018","author":"M P Thao","year":"2018","journal-title":"Int J Endocrinol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"11950","DOI":"10.1038\/s41598-017-12350-2","article-title":"Association of HLA-B and HLA-DRB1 polymorphisms with antithyroid drug-induced\n                    agranulocytosis in a Han population from northern China","volume":"7","author":"Y He","year":"2017","journal-title":"Sci Rep"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S2213-8587(16)00113-3","article-title":"Genetic variants associated with antithyroid drug-induced agranulocytosis: A\n                    genome-wide association study in a European population","volume":"4","author":"P Hallberg","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/cpt.309","article-title":"HLA-B*38:02:01 predicts carbimazole\/methimazole-induced\n                    agranulocytosis","volume":"99","author":"C L Cheung","year":"2016","journal-title":"Clin Pharmacol Ther"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"7633","DOI":"10.1038\/ncomms8633","article-title":"Genetic determinants of antithyroid drug-induced agranulocytosis by human\n                    leukocyte antigen genotyping and genome-wide association study","volume":"6","author":"P L Chen","year":"2015","journal-title":"Nat Commun"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s40618-020-01319-0","article-title":"Association of MICA gene polymorphisms with thionamide-induced\n                    agranulocytosis","volume":"44","author":"P Ma","year":"2021","journal-title":"J Endocrinol Invest"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1158\/2326-6066.CIR-15-0098","article-title":"NKG2D receptor and its ligands in host defense","volume":"3","author":"L L Lanier","year":"2015","journal-title":"Cancer Immunol Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3389\/fimmu.2018.00441","article-title":"NKG2D: A master regulator of immune cell responsiveness","volume":"9","author":"F M Wensveen","year":"2018","journal-title":"Front Immunol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"438","DOI":"10.3390\/cancers11040438","article-title":"NKG2D polymorphism in melanoma patients from southeastern Spain","volume":"11","author":"L Gimeno","year":"2019","journal-title":"Cancers (Basel)"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/cei.12891","article-title":"Association of NKG2D gene variants with susceptibility and severity of\n                    rheumatoid arthritis","volume":"187","author":"C M Mariaselvam","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1002\/jmv.21855","article-title":"Association of NKG2D genetic polymorphism with susceptibility to chronic\n                    hepatitis B in a Han Chinese population","volume":"82","author":"J Ma","year":"2010","journal-title":"J Med Virol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/ijc.23517","article-title":"Investigation of cholangiocarcinoma associated NKG2D polymorphisms in colorectal\n                    carcinoma","volume":"123","author":"E Melum","year":"2008","journal-title":"Int J Cancer"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.humimm.2019.07.276","article-title":"Haplotype block 1 variant (HB-1v) of the NKG2 family of receptors","volume":"80","author":"W G Vazquez-Gonzalez","year":"2019","journal-title":"Human 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Genet"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1600-0609.1988.tb00803.x","article-title":"Methimazole-induced agranulocytosis: Growth inhibition of myeloid progenitor\n                    cells by the patient\u2019s serum","volume":"40","author":"D Douer","year":"1988","journal-title":"Eur J Haematol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.4049\/jimmunol.1102002","article-title":"Human NK Cells induce neutrophil apoptosis via an NKp46- and Fas-dependent\n                    mechanism","volume":"188","author":"F B Thoren","year":"2012","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"5332","DOI":"10.4049\/jimmunol.1303180","article-title":"A polysaccharide virulence factor of a human fungal pathogen induces neutrophil\n                    apoptosis via NK cells","volume":"192","author":"P Robinet","year":"2014","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1002\/iid3.359","article-title":"MICA polymorphisms associated with antithyroid drug-induced agranulocytosis in\n                    the Chinese Han population","volume":"8","author":"X Gong","year":"2020","journal-title":"Immun Inflamm Dis"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2206-2242.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:31:10Z","timestamp":1730806270000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2206-2242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":32,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,1,18]]},"published-print":{"date-parts":[[2024,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2206-2242","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"type":"print","value":"0947-7349"},{"type":"electronic","value":"1439-3646"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}