{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T20:03:59Z","timestamp":1764187439043,"version":"3.46.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Patients with primary sclerosing cholangitis (PSC) carry increased risks for malignancy, among which cholangiocarcinoma (CCA) is the most frequent. We aimed to characterise a cohort of patients with PSC and intrahepatic CCA (iCCA) and to compare this cohort with CCA in different localisations.<\/jats:p>\n                  <jats:p>Methods We performed a retrospective analysis of our medical database from 01.01.2007 to 30.06.2023 and differentiated CCA according to its localisation within the biliary tract into iCCA, perihilar CCA (pCCA), distal CCA (dCCA), and gallbladder carcinoma (GBC).<\/jats:p>\n                  <jats:p>Results We identified 8 (28%) patients with iCCA, 14 (48%) patients with pCCA, 6 (21%) patients with GBC, and 1 (3%) patient with dCCA without significant differences in gender distribution and mean age. Mean time between diagnosis of PSC and CCA was 158\u00b184 months for iCCA, 93\u00b194 months for pCCA, and 77\u00b169 months for GBC (p=0.230). At the time of CCA diagnosis, advanced-stage disease was present in 6 (75%) patients with iCCA, 13 (93%) patients with pCCA, and 2 (40%) patients with GBC (p=0.050). Only 5 (63%) patients with iCCA received curatively intended surgery, of whom 4 (80%) patients developed recurrence after a mean time of 38\u00b131 months. Mean survival time in patients with iCCA (35\u00b133 months) lay between patients with pCCA (14\u00b18 months) and patients with GBC (57\u00b158 months), but the difference was not statistically significant (p=0.131).<\/jats:p>\n                  <jats:p>Conclusion Patients with PSC and iCCA showed an advanced tumour stage at diagnosis and limited long-time survival, which was classified between pCCA with worse prognosis and GBC with better prognosis.<\/jats:p>","DOI":"10.1055\/a-2207-5519","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T20:12:15Z","timestamp":1704831135000},"page":"37-42","source":"Crossref","is-referenced-by-count":1,"title":["Tumour stage and overall survival in patients with intrahepatic cholangiocarcinoma and primary sclerosing cholangitis \u2013 a retrospective cohort study"],"prefix":"10.1055","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6752-0690","authenticated-orcid":false,"given":"Christoph","family":"Schramm","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Transplantational Medicine, University Hospital Essen, and Faculty of Medicine, University of Duisburg-Essen, Essen, Germany, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaz","family":"Sapuk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Transplantational Medicine, University Hospital Essen, and Faculty of Medicine, University of Duisburg-Essen, Essen, Germany, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Hoyer","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery, University Hospital Essen, and Faculty of Medicine, University of Duisburg-Essen, Essen, Germany, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Rad\u00fcnz","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery, University Hospital Essen, and Faculty of Medicine, University of Duisburg-Essen, Essen, Germany, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Transplantational Medicine, University Hospital Essen, and Faculty of Medicine, University of Duisburg-Essen, Essen, Germany, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1016\/j.cgh.2021.08.039","article-title":"Epidemiology, natural history, and outcomes of primary sclerosing cholangitis: a systematic review of population-based studies","volume":"20","author":"PJ Trivedi","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/hep.26565","article-title":"EpiPSCPBC Study Group. 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