{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:32:48Z","timestamp":1740166368823,"version":"3.37.3"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Plast Surg"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kearns\u2013Sayre syndrome (KSS) is a rare mitochondrial disease that affects young adults, due to a deletion of mitochondrial DNA and characterized by the triad: age of onset lower than 20 years, chronic progressive external ophthalmoplegia, and an atypical pigmentary retinopathy. It is also characterized by other endocrine, neurological, and especially cardiac impairment with a very high risk of cardiac complications during surgical procedures under all types of anesthesia.<\/jats:p><jats:p>We report a case of KSS revealed by severe bilateral ptosis and confirmed by a muscle biopsy with \u201cragged red fibers.\u201d The ptosis was surgically managed by cautious Frontal suspension under local anesthesia \u201cFrontal nerve block.\u201d Through this case, we discuss challenges in the management of KSS patients.<\/jats:p>","DOI":"10.1055\/a-2207-7587","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T01:31:28Z","timestamp":1699579888000},"page":"182-186","source":"Crossref","is-referenced-by-count":0,"title":["Management of Ptosis in Kearns\u2013Sayre Syndrome: A Case Report and Literature Review"],"prefix":"10.1055","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5334-980X","authenticated-orcid":false,"given":"Moulay O.","family":"Moustaine","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, CHU Souss Massa, Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2312-8355","authenticated-orcid":false,"given":"Zakaria","family":"Azemour","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, CHU Souss Massa, Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1018-2310","authenticated-orcid":false,"given":"Frarchi","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, CHU Souss Massa, Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8424-391X","authenticated-orcid":false,"given":"Othman","family":"Benlanda","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Resuscitation, CHU Souss Massa, Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-1054","authenticated-orcid":false,"given":"Hicham","family":"Nassik","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Resuscitation, CHU Souss Massa, Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-7442","authenticated-orcid":false,"given":"Mehdi","family":"Karkouri","sequence":"additional","affiliation":[{"name":"General Laboratory of Pathological Anatomy, CHU Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1212\/WNL.38.9.1339","article-title":"Deletions of mitochondrial DNA in Kearns-Sayre syndrome","volume":"38","author":"M Zeviani","year":"1988","journal-title":"Neurology"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s11910-010-0096-4","article-title":"A diagnostic algorithm for metabolic myopathies","volume":"10","author":"A Berardo","year":"2010","journal-title":"Curr Neurol Neurosci Rep"},{"volume-title":"Kearns-Sayre Syndrome","year":"2022","author":"A Shemesh","key":"ref3"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1001\/archopht.1958.00940080296016","article-title":"Retinitis pigmentosa, external ophthalmophegia, and complete heart block: unusual syndrome with histologic study in one of two cases","volume":"60","author":"T P Kearns","year":"1958","journal-title":"AMA Arch Opthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-3-319-95046-4_30","article-title":"Mitochondrial disorder: Kearns-Sayre syndrome","volume":"1085","author":"S H Tsang","year":"2018","journal-title":"Adv Exp Med Biol"},{"issue":"02","key":"ref6","first-page":"51","article-title":"[Disorders of mitochondrial energy metabolism in patients with the Kearns-Sayre syndrome]","volume":"141","author":"M Capkov\u00e1","year":"2002","journal-title":"Cas Lek Cesk"},{"key":"ref7","first-page":"325","article-title":"Kearns-Sayre syndrome: a case series of 35 adults and children","volume":"7","author":"S Khambatta","year":"2014","journal-title":"Int J Gen 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mitochondrial DNA deletions","volume":"1","author":"C T Moraes","year":"1992","journal-title":"Nat Genet"},{"issue":"06","key":"ref12","first-page":"1240","article-title":"Anesthetic management for a patient with Kearns-Sayre syndrome","volume":"80","author":"T Kitoh","year":"1995","journal-title":"Anesth Analg"},{"key":"ref13","first-page":"806086","article-title":"General anaesthesia for laparoscopic cholecystectomy in a patient with the Kearns-Sayre syndrome","volume":"2011","author":"P Calzavacca","year":"2011","journal-title":"Case Rep Anesthesiol"},{"issue":"02","key":"ref14","first-page":"155","article-title":"Anesthesia management of a patient with Kearn's-Sayre syndrome","volume":"4","author":"B M \u00c7akmak","year":"2013","journal-title":"J Clin Anal Med"},{"issue":"04","key":"ref15","first-page":"232","article-title":"Anesthetic management of Kearns-Sayre syndrome. Case report","volume":"68","author":"J Talav\u00e1n Serna","year":"2021","journal-title":"Rev Esp Anestesiol Reanim (Engl Ed)"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3349\/ymj.2000.41.5.676","article-title":"Transient improvement of pyruvate metabolism after coenzyme Q therapy in Kearns-Sayre syndrome: MRS study","volume":"41","author":"C Choi","year":"2000","journal-title":"Yonsei Med J"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5999\/aps.2015.42.2.214","article-title":"Treatment of eyelid ptosis due to Kearns-Sayre syndrome using frontalis suspension","volume":"42","author":"L Weitgasser","year":"2015","journal-title":"Arch Plast Surg"}],"container-title":["Archives of Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2207-7587.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:52:48Z","timestamp":1730807568000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2207-7587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,9]]},"references-count":17,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,4,8]]},"published-print":{"date-parts":[[2024,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2207-7587","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2234-6163","2234-6171"],"issn-type":[{"type":"print","value":"2234-6163"},{"type":"electronic","value":"2234-6171"}],"subject":[],"published-other":{"date-parts":[[2023,11,9]]},"published":{"date-parts":[[2023,11,9]]}}}